Publications by authors named "Lin Xin-Zhu"
Background: Bronchopulmonary Dysplasia (BPD) is a chronic lung disease affecting preterm infants, with limited prevention and treatment options. Inhaled Nitric Oxide (iNO) is sometimes used to treat Persistent Pulmonary Hypertension of the Newborn (PPHN) and Hypoxemic Respiratory Failure (HRF), and its impact on BPD development remains debated.
Objective: To assess whether iNO-related factors are potential contributors to the development of BPD Grade Ⅱ-Ⅲ in very premature infants (VPI) diagnosed with PPHN or HRF at birth using Propensity Score Matching (PSM).
Background: Limited research has been conducted on self-harm among preadolescents in China. This study investigated the influence of multidimensional stress on high levels of self-harm behavior in preadolescents.
Method: This large-scale cross-sectional study of 7-14-year-old primary school students in grades 3-6 was conducted in Southwest China between September and December 2020.
Article Synopsis
- This study examined the use and effects of inhaled nitric oxide (iNO) in preterm infants under 34 weeks gestational age across eight hospitals in China over a span of ten years.
- A total of 434 infants were analyzed, categorized into three gestational age groups: extremely preterm (24-27 weeks), very preterm (28-31 weeks), and moderate preterm (32-33 weeks), focusing on treatment outcomes and complications.
- Findings indicated that extremely preterm infants had the highest rates of iNO treatment and associated complications, with mortality rates inversely related to gestational age and birth weight, underscoring the importance of iNO in managing severe respiratory issues in this population.
Objective: To investigate the use of inhaled nitric oxide (iNO) in hospitalized preterm infants in China over 10 years and its clinical outcomes.
Methods: A total of 616 premature infants who were administered iNO in the Neonatology Departments of 5 Class A tertiary hospitals in China for ten years from January 2013 to December 2022 were included retrospectively. Based on their enrollment periods, the patients were divided into two groups: Group 1 from January 2013 to December 2017 and Group 2 from January 2018 to December 2022, respectively.
Background: Due to regional and cultural differences, the current status of extremely preterm infants(EPIs) treatment across different areas of mainland China remains unclear. This study investigated the survival rate and incidence of major diseases among EPIs in the southwest area of Fujian province.
Method: This retrospective and multicenter study collected perinatal data from EPIs with gestational ages between 22-27w and born in the southwest area of Fujian province.
[Efficacy of therapeutic hypothermia on mild neonatal hypoxic-ischemic encephalopathy: a prospective randomized controlled study].
Zhongguo Dang Dai Er Ke Za Zhi
August 2024
Article Synopsis
- A study was conducted on 153 neonates diagnosed with mild hypoxic-ischemic encephalopathy (HIE) to evaluate the effectiveness of therapeutic hypothermia.
- The neonates were split into two groups—one receiving therapeutic hypothermia and the other not—with their clinical outcomes analyzed using the Barkovich scoring system.
- Results indicated therapeutic hypothermia significantly reduced MRI abnormalities and brain injury compared to the non-hypothermia group, and showed no serious adverse effects, suggesting it may provide neuroprotective benefits for these infants.
Background: Circadian rhythms impact metabolism and the therapeutic effects of drugs. The purpose of this study was to determine the association between and polymorphisms and caffeine citrate treatment response in infants with apnea of prematurity.
Methods: A total of 221 preterm infants of gestational age <34 weeks were included in this study (160 in the response group and 61 in the non-response group).
Article Synopsis
- - The study focused on creating a real-time risk prediction model for extrauterine growth retardation (EUGR) in very preterm infants, utilizing data from 2,514 infants split into training and validation sets.
- - Key predictors, including birth weight, small for gestational age, and others, were identified and used in a logistic regression model, with a nomogram visualization to help assess risk.
- - The model demonstrated strong predictive ability, achieving ROC curve areas of 83.1% and 84.6% for the training and validation sets, respectively, and indicating good calibration and clinical applicability for risk assessment.
Background: Hyperglycemia in pregnancy (HGP) has generally been considered a risk factor associated with adverse outcomes in offspring, but its impact on the short-term outcomes of very preterm infants remains unclear.
Methods: A secondary analysis was performed based on clinical data collected prospectively from 28 hospitals in seven regions of China from September 2019 to December 2020. According to maternal HGP, all infants were divided into the HGP group or the non-HGP group.
Article Synopsis
- NEC is a serious illness that mostly affects premature babies, showing up usually after they are a week old.
- This study looked at data from over 2,500 premature babies to understand the causes of late-onset NEC and how it affects their health in the short term, especially focusing on their nutrition.
- Results showed that babies with late-onset NEC faced more health issues like anemia and required more treatments, had slower weight gain, and breastfeeding rates were lower among them.
Objective: The aim of this study was to investigate the effects of soybean, medium-chain triacylglycerols (MCTs), olive oil, and fish oil (SMOF) on short-term clinical outcomes, physical growth, and extrauterine growth retardation (EUGR) in very preterm infants.
Methods: This was a multicenter retrospective cohort study of very preterm infants hospitalized in neonatal intensive care units at five tertiary hospitals in China between January 2021 and December 2021. According to the type of fat emulsion used in parenteral nutrition (PN), eligible very preterm infants were divided into the MCTs/long-chain triacylglycerol (MCT/LCT) group and SMOF group.
[Recent research on inhaled nitric oxide in preterm infants with a gestational age of <34 weeks].
Zhongguo Dang Dai Er Ke Za Zhi
September 2023
Article Synopsis
- Nitric oxide acts as a messenger molecule that helps widen blood vessels, particularly in the lungs, allowing better blood flow without affecting overall body circulation pressure.
- Inhaled nitric oxide (iNO) is recommended for use in full-term and late preterm infants to treat conditions like persistent pulmonary hypertension and hypoxic respiratory failure.
- Recent studies indicate an increasing off-label use of iNO for preterm infants under 34 weeks gestation, prompting a review of its effectiveness, safety, dosing, and combination with other drugs for better clinical outcomes.
Article Synopsis
- The study aims to assess how two different fat emulsions affect clinical outcomes in preterm infants on varying lengths of parenteral nutrition (PN).
- Preterm infants were split into two groups receiving either medium/long-chain triglyceride fat emulsion (MCT/LCT) or multi-oil fat emulsion (SMOF), and comparisons were made on clinical characteristics and outcomes.
- Results indicated that the SMOF group experienced lower triglyceride levels and significantly reduced risks of nutrition-related complications like cholestasis and bronchopulmonary dysplasia with longer PN durations, suggesting that SMOF is a better option for long-term use in preterm infants.
Background: To analyze the real-world growth pattern of very premature infants (VPI) with small for gestational age (SGA) after birth by using the ΔZ value of weight at discharge.
Methods: The clinical data were collected from 28 hospitals in China from September 2019 to December 2020. They were divided into the EUGR(Extrauterine Growth Restriction) and the non-EUGR group according to the criterion of ΔZ value of weight at discharge < -1.
Article Synopsis
- Postpartum depression can occur within a year after childbirth and is influenced by various factors, including trait mindfulness, which has been linked to better relationship quality among couples.
- This study aimed to explore the relationships between mindfulness, marital quality, anxiety, and depression among new mothers in a large city in western China during the COVID-19 era, focusing specifically on the mediating role of mindfulness.
- Results indicated that while postpartum anxiety and depression levels didn’t significantly differ by region or ethnicity, urban mothers reported more marital conflict and issues compared to rural mothers, with distinct negative correlations found between mindfulness and anxiety/depression.
Background: It is proposed that the development of parenteral nutrition-associated cholestasis (PNAC) was significantly associated with preterm birth, low birth weight, infection, etc.; however, the etiology and pathogenesis of PNAC are not fully understood. Most of the studies examining PNAC-associated risk factors were single-center studies with relatively small sample sizes.
View Article and Find Full Text PDFObjective: This study compared the clinical effects of two different lipid emulsions in premature infants with gestational age < 32 weeks (VPI) or birth weight < 1500 g (VLBWI) to provide an evidence-based medicine basis for optimizing intravenous lipid emulsion.
Methods: This was a prospective multicenter randomized controlled study. A total of 465 VPIs or VLBWIs, admitted to the neonatal intensive care unit of five tertiary hospitals in China from March 1, 2021 to December 31, 2021, were recruited.
Objective: To investigate the protective effect of high-proportion breast milk feeding (>50%) on intraventricular hemorrhage (IVH) in very preterm infants (VPIs).
Methods: This was a retrospective secondary analysis of a prospective multi-center study, which included 604 VPIs from six hospitals in eastern China between September 2019 and December 2020. The 604 VPIs were divided into two groups according to whether IVH occurred.
Objectives: The management of enteral nutrition in very preterm infants (VPIs) is still controversial, and there is no consensus on the optimal time point after birth at which enteral nutrition can be started. The aim of this study was to investigate the effect of early initiation of enteral nutrition on the short-term clinical outcomes of VPIs.
Methods: Data of infants (n = 2514) born before 32 wk of gestation were collected from 28 hospitals located in seven different regions of China.
Objectives: To study the influencing factors for the development and severity of bronchopulmonary dysplasia (BPD) in preterm infants with a gestational age of <32 weeks and a birth weight of <1 500 g.
Methods: A retrospective analysis was performed on the medical data of preterm infants with a gestational age of <32 weeks and a birth weight of <1 500 g who were admitted to Women and Children's Hospital Affiliated to Xiamen University from January 1, 2017 to December 31, 2021. According to oxygen dependence on day 28 after birth, they were divided into two groups: BPD (=218) and non-BPD (=142).
Background: The incidence of extrauterine growth retardation (EUGR) varies considerably in different countries due to the distinct definitions and inclusion criteria of individual studies. Most studies included small for gestational age (SGA) very preterm infants (VPIs), resulting in a higher incidence of EUGR. Experts have suggested the accurate definition of "EUGR" in SGA infants is not "true EUGR".
View Article and Find Full Text PDFObjective: To investigate the incidence and related factors of extrauterine growth retardation (EUGR) and "true EUGR" in very preterm infants (VPI) from different regions of China.
Materials And Methods: Clinical data of VPI were prospectively collected from 28 hospitals in seven different regions of China from September 2019 to December 2020. The infants were divided into a small for gestational age (SGA) group or non-SGA group at birth, with non-SGA infants at 36 weeks of gestation or at discharge being further divided into a EUGR group or a non-EUGR group.
Short-term effects of fresh mother's own milk in very preterm infants.
Matern Child Nutr
January 2023
Fresh mother's own milk (MOM) can protect preterm infants from many complications. Often MOM is pasteurized for safety, which can deactivate cellular and bioactive components with protective benefits. Questions remain regarding whether pasteurized MOM provides the same benefits as fresh MOM.
View Article and Find Full Text PDF[Recent research on gene polymorphisms related to caffeine therapy in preterm infants with apnea of prematurity].
Zhongguo Dang Dai Er Ke Za Zhi
July 2022
Article Synopsis
- Apnea of prematurity (AOP) is a common condition in preterm infants caused by underdeveloped respiratory control centers, which can lead to serious consequences if left untreated.
- Caffeine is the primary treatment for AOP, but its effectiveness can differ among infants, prompting research into genetic factors that influence this variability.
- Recent studies focus on specific gene polymorphisms that affect caffeine's efficacy, aiming to improve individualized treatment strategies for AOP.