Publications by authors named "Lin Rui Dong"
Objective: Matrix metalloproteinases (MMPs) are essential for tissue formation, neuronal network remodeling, and blood-brain barrier integrity. MMPs have been widely studied in acute brain diseases. However, the relationship with Parkinson's disease (PD) remains unclear.
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- The study aimed to compare gray matter volume (GMV) and white matter volume (WMV) between Parkinson's disease (PD) patients and healthy individuals, and investigate any links between structural and functional brain abnormalities.
- Utilizing MRI techniques, researchers examined 180 PD patients and 58 healthy controls, identifying notable differences in brain structure and activity.
- Findings revealed that PD patients had reduced whole-brain GMV, particularly in key areas like the right superior temporal gyrus and left frontotemporal space, and these structural changes correlated with age and motor function impairment, suggesting potential imaging biomarkers for disease progression.
Background: The "postural instability/gait difficulty" (PIGD) and "tremor-dominant" (TD) motor subtypes of Parkinson's disease (PD) differ in their clinical manifestations. The neurological basis of these differences is unclear.
Methods: We performed voxel-based morphometric analysis and measured amplitudes of low-frequency fluctuation (ALFF) on 87 PIGD patients and 51 TD patients.
Purpose: Excessive daytime sleepiness (EDS) is a common non-motor symptom in Parkinson's disease (PD), but its neuropathology remains elusive. Our goal is to explore the potential neural substrates of EDS in a large sample of individuals with PD.
Methods: We recruited 48 PD patients with and 87 PD patients without EDS.
Introduction: Pain in Parkinson's disease is poorly understood, and most patients with pain do not respond to dopaminergic drugs. We aimed to explore the mechanisms of dopa-responsive and -unresponsive pain by comparing such patients against patients without pain in terms of neural activity and functional connectivity in the brain.
Methods: We prospectively examined 31 Parkinson's patients with dopa-responsive pain, 51 with dopa-unresponsive pain and 93 without pain using resting-state functional magnetic resonance imaging.
Purpose: The etiology of constipation in Parkinson's disease is largely unknown. The aim of this study was to explore changes in regional neural activity and functional connections associated with constipation in a large cohort of individuals with Parkinson's disease.
Methods: We prospectively recruited 106 patients with Parkinson's disease with constipation and 73 patients with Parkinson's disease without constipation.