The association between nutritional-inflammatory status and chronic kidney disease prognosis: a population-based study.

Background: Chronic kidney disease (CKD) prognosis is closely tied to the interplay between nutrition and inflammation. However, comprehensive nutritional-inflammatory indices for prognostic evaluation are rare in CKD. This study explored the association of the advanced lung cancer inflammation index (ALI) with estimated glomerular filtration rate (eGFR) and all-cause mortality in CKD patients.

Efficacy and safety of non-ablative vs. ablative lasers for acne scarring: A meta-analysis.

Acne scarring significantly affects physical appearance and psychological well-being, prompting the exploration of various treatment options, including ablative and non-ablative laser therapies. The debate around their efficacy and safety persists, underscoring the need for a comprehensive analysis. This meta-analysis compares the therapeutic outcomes and safety profiles of ablative and non-ablative laser treatments for acne scars, based on a comprehensive review of clinical trials conducted up to March 2023.

Efficacy and safety of self-retaining double-needle barb suture in transabdominal path robot-assisted laparoscopic partial nephrectomy for T1 renal cancer.

Objectives: This study evaluated the safety and efficacy of self-retaining barbed double-layer sutures (SRBDS) used for wound sutures in stage T1 renal cancer undergoing peritoneal robot-assisted laparoscopic partial renal resection.

Methods: A total of 50 patients undergoing robot-assisted laparoscopic partial nephrectomy (RAPN) for localized renal tumors (< 7 cm) in Zhejiang Provincial People's Hospital from January 2021 to January 2022 were selected. The experimental-group and the control-group randomly included 25 patients, respectively.

Endogenous gliadin/glutenin fractions regulate the short/long-term retrogradation behavior of starch-gluten gels.

This study explored composite gels' structural properties and short/long-term retrogradation behavior by varying ratios of wheat starch to gluten and gliadin to glutenin. The results showed that as the proportion of gluten increased, the degree of order and crystalline conformation was lost, manifested by an increase in the gel network's porosity and protein aggregation. The dilution effect of gluten on starch and the water competition significantly reduced the viscosity and elasticity of the system, and the ratio of glu75-gli25 had the most significant impact on the viscoelasticity.

KLF5 enhances CXCL12 transcription in adipose-derived stem cells to promote endothelial progenitor cells neovascularization and accelerate diabetic wound healing.

Background: Adipose-derived stem cells (ADSCs) have been shown to accelerate diabetic wound healing by promoting neovascularization, though the underlying mechanisms are not fully understood. This study aims to explore whether ADSCs influence endothelial progenitor cells (EPCs) function to enhance diabetic wound healing.

Methods: Human adipose-derived stem cells (hADSCs) were isolated from patient adipose tissue and cultured under normal and high glucose (HG) conditions.

Successful outcome of a refractory IgA vasculitis nephritis in children treated with telitacicept.

IgA vasculitis (IgAV) is the most prevalent form of vasculitis in children. While most cases of IgAV present with mild clinical symptoms and generally have a favorable prognosis, some children with IgAV nephritis may experience persistent heavy proteinuria, which is at risk of progressing to end-stage renal disease. Despite the administration of various immunosuppressive agents, treatment outcomes for these children are often suboptimal.

Synthesis and Biological Evaluation of Novel Triazine Analogs as Rad6 Inhibitors.

Unlabelled: Rad6 is an E2 ubiquitin-conjugating enzyme that plays critical roles in genome maintenance and proteostasis. Rad6 is frequently overexpressed in many cancers and promotes cancer development, progression, and chemotherapy resistance.

Purpose: Given its role in cancer development and progression, Rad6 is an underexplored therapeutic target.

Overexpression pattern, function, and clinical value of proteasome 26S subunit non-ATPase 6 in hepatocellular carcinoma.

Background: In recent years, many studies have shown that proteasome 26S subunit non-ATPase 6 (PSMD6) plays an important role in the occurrence and development of malignant tumours. Unfortunately, there are no reports on the evaluation of the potential role of PSMD6 in hepatocellular carcinoma (HCC).

Aim: To comprehensively evaluate the overexpression pattern and clinical significance of PSMD6 in HCC tissues.

Optimizing the zymogram of exogenous proteases in broiler diets by in vitro simulated gastrointestinal digestion and response surface methodology.

Low protein digestibility causes intestinal flora imbalance, wet litter, and nitrogen pollution. The present study aimed to explore the optimal zymogram of exogenous acid protease (ACP), neutral protease (NEP), alkaline protease (ALP), and keratinase (KEA) in corn-soybean based diets for broilers. The hydrolysis performances of the four monocomponent proteases were presented by enzymatic hydrolysate gross energy (EHGE) and improved dry matter digestibility (IDMD), which were tested via the in vitro simulated digestion method.

A pharmacovigilance study based on the FAERS database focusing on anticoagulant and hormonal drugs that induce vaginal hemorrhage.

Numerous medications have been associated with an increased risk of vaginal hemorrhage in women. In this study, we analyzed data from the FDA Adverse Event Reporting System (FAERS), focusing on reports of drug-induced vaginal bleeding in women. Risk signals were assessed using disproportionality analyses, specifically the reporting odds ratio (ROR) and the proportional reporting ratio (PRR), to identify significant associations between drugs and adverse events.

Production of p-anisaldehyde via whole-cell transformation using recombinant E. coli expressing trans-anethole oxygenase.

p-Anisaldehyde, a fragrance and flavour with important roles in food, cosmetics, and drug industries, is currently synthesized through chemical methods. Production of p-anisaldehyde by chemical oxidation of trans-anethole in industry gives rise to excessive by-products and adverse environmental impacts, whereas biological process would address such problems. Here, we presented a process of biotransformation of trans-anethole for production of p-anisaldehyde.

Ion type-based formation rules and functional properties of polysaccharide-starch aerogels with chitooligosaccharide, xanthan gum, and locust bean gum: A comparative study.

Polysaccharide ion types may play a regulatory role in the functionalization development of starch-polysaccharide-based gels, although the relevant mechanisms remain to be elucidated. This study provides a simple and effective strategy for developing gels suitable for different adsorption scenarios by adding different ratios and ion types of polysaccharides. The addition of locust bean gum (LBG, neutral charge) and xanthan gum (XG, -/negative charge) increased the viscosity of wheat gels, with XG increasing more significantly at the same addition.

Highly Efficient Production of Sialyllacto--tetraose C via Screening of Beneficial β1,4-galactosyltransferase and α2,6-sialyltransferase.

Biological production of human milk oligosaccharides (HMOs) using metabolically engineered strains is a research hotspot in food biotechnology, but less effort has been made on the biological production of sialylated complex HMOs. Sialyllacto--tetraose c is the only monosialylated complex HMO in the top 15 HMOs. In this study, the metabolic pathway of LST c was constructed in BL21(DE3) by introducing three sequential glycosyltransferases: β1,3--acetylglucosaminyltransferase, β1,4-galactosyltransferase, and α2,6-sialyltransferase.

Oxygen evolution reaction on NiFe-LDH/(Ni,Fe)OOH: theoretical insights into the effects of electronic structure and spin-state evolution.

NiFe-layered double hydroxides (NiFe-LDH) have emerged as promising oxygen evolution reaction (OER) catalysts in alkaline medium, but their commercial applications are limited due to the decrease in their activity as the electrolyte becomes less alkaline. Thus, a comprehensive understanding of the OER mechanism of NiFe-LDH in alkaline medium is desirable for the rational design of new catalysts with improved performances. Especially, their spin-related factors have rarely been systematically investigated during the OER (diamagnetic HO → paramagnetic O).

Polarized topological invariance frequency conversion on high-fidelity information transfer.

A cross-band information converter, which links communication and storage modules operating at different wavelengths, is crucial for the development of optical vortex-based information networks. However, due to nonlinear efficiency dependence on orbital angular momentum (OAM), the traditional intensity or polarization distribution-based recognition distortion emerges. Here, by employing the optical vector vortex with a tailored polarization mode as the information carrier of communication network, and the polarization topology one-to-one mapping as the mode identification method, we demonstrate a simple yet flexible frequency converter based on sum-frequency generation (SFG) that preserves the topological invariance of polarization, enabling high-fidelity information transmission.

Temozolomide monotherapy versus combination therapies in melanoma: a meta-analysis of efficacy and safety.

Temozolomide is used in melanoma therapy, but the comparative efficacy and safety of monotherapy vs combination therapies are unclear. This meta-analysis evaluates temozolomide monotherapy vs combination therapies in melanoma patients. PubMed, Embase, and Cochrane Library were searched up to August 2024 for studies comparing temozolomide monotherapy with combination therapies in melanoma.

Effect of microwave treatment on the structural and physicochemical properties of amylose partially removed sorghum starch.

This study aimed to probe the influence of amylose in starch granules on starch modification. Part of the amylose from sorghum starch was removed through warm water leaching, and the samples were then microwaved. The effects of treatments on starch structure, physicochemical properties, and digestibility were researched.

In Vitro Evaluation of Ruminal Digestibility, Fermentation Characteristics, and Bacterial Diversity of Kenaf Crop at Various Cutting Heights.

The current study investigated the in vitro degradability, in vitro gas production, methane (CH) production, and ruminal bacterial community of kenaf plants cut at different heights (130, 160, 190, 220, and 250 cm). These samples were subjected to an in vitro batch culture system using buffalo rumen fluid to measure gas and CH production at 3, 6, 9, 12, 24, 36, 48, and 72 h of incubation. Results reveal that crude protein (CP) concentration was the highest at the 220 cm height compared with the other heights.

Chitosan-Based Porous Carbon Materials with Built-In Lewis Acid Boron Sites for Enhanced CO Capture and Conversion via an Electron-Inducing Effect.

Electron-induced effects, which are prevalent in adsorption and heterogeneous catalytic reactions, can significantly influence the state and uptake of adsorbates. Here, we demonstrate the in situ doping of electron-deficient boron into the backbone of chitosan-based porous carbon materials. Despite a reduction in specific surface area, the resulting boron-doped porous carbons (NBPCs) exhibit an enhanced CO adsorption performance, with sample NBPC-10 achieving CO adsorption capacities of 7.

Glutaric anhydride esterification promotes wheat starch/glutein composite gel interaction: Formation, characterization, and oleogel applications.

This study constructed a composite system with different ratios (100:0, 95:5, 90:10, and 80:20) of glutein compounded with various esterified starch (3 % and 6 %). The results demonstrated that the esterification process enhanced the viscosity of the starch gel system. Furthermore, the optimal esterification level (3 %) facilitated the formation of a dense composite gel network, as observed through microstructure observation.

Rational design of a starch/whey protein isolate/caffeic acid ternary system to alleviate gel deterioration during freeze-thaw cycles.

To strengthen starch gel quality and improve the deterioration from freeze-thaw cycles, corn starch/whey protein isolate (WPI)/caffeic acid (CA) composite gels were rationally constructed in this study. The results showed that the introduction of WPI and CA significantly optimized the microstructure of the gels, an observation verified by SEM and CLSM. In addition, FT-IR and XRD analyses further revealed that the interaction mechanism within the composite gel was mainly due to the reinforcement of hydrogen bonds.

Risk factors and outcomes associated with true knots of the umbilical cord: A retrospective study.

Objective: To investigate the pregnancy outcomes and independent risk factors associated with true knots of the umbilical cord (TKUC).

Materials And Methods: This retrospective study included 8140 deliveries at Fujian Maternal and Child Health Hospital from 2017 to 2021. Mothers and newborns diagnosed with TKUC were included in the TKUC group, while the others were included in the control group.

The adiponectin-PPARγ axis in hepatic stellate cells regulates liver fibrosis.

Hepatic stellate cells (HSCs) are key drivers of local fibrosis. Adiponectin, conventionally thought of as an adipokine, is also expressed in quiescent HSCs. However, the impact of its local expression on the progression of liver fibrosis remains unclear.

Effects of Extract on Growth Performance, Nutrient Apparent Digestibility, Serum Parameters, and Fecal Microbiota in Finishing Pigs.

This study investigated the effects of extract (FAE) on growth performance, nutrient apparent digestibility, serum parameters, fecal microbial composition, and short-chain fatty acids (SCFAs) in finishing pigs. In total, 75 Duroc × Landrace × Yorkshire pigs (equally divided by sex), with an initial body weight of 79.49 ± 4.

From PD-1/PD-L1 to tertiary lymphoid structures: Paving the way for precision immunotherapy in cholangiocarcinoma treatment.

Cholangiocarcinoma (CCA) is a highly malignant hepatobiliary tumor characterized by limited treatment options and poor prognosis. The recent rise of immunotherapy has significantly influenced research in this field. This study presents a bibliometric analysis of 416 articles retrieved from the WOSCC, Wan fang Data, CNKI and VIP databases, spanning contributions from 32 countries, 589 institutions and 3,200 authors.