Metabolic effects and clinical outcomes of olanzapine in schizophrenia: A systematic review and meta-analysis.

Objective: To evaluate the metabolic changes of patients with schizophrenia treated with olanzapine and analyze the correlation between the dosage of the drug, the blood concentration and the clinical response, so as to provide a reference for the clinical diagnosis and treatment.

Methods: PubMed, web of science, Cochrane Library, MEDLINE databases were used to search for studies on olanzapine treatment in patients with schizophrenia, to extract changes in body weight, BMI, waist circumference, cholesterol, PANSS (The Positive and Negative Syndrome Scale), SAPS (The Positive Syndrome Scale), SANS (The Negative Syndrome Scale), BPRS (Brief Psychiatric Rating Scale), CGI (Clinical Global Impressions Ratings), and so on for meta-analysis, and to analyze the correlation of medication dose, blood concentration, and clinical response.

Results: Twenty clinical trials (1839 participants, 1058 male and 781 female patients) were included in this meta-analysis.

Type D Personality As a Risk Factor for 3-Year Cardiovascular Events in Patients With Coronary Artery Disease and Their Spouse: A Prospective Cohort Study.

Aims: Type D personality has been established as an independent psychological risk factor for adverse outcomes in coronary artery disease (CAD) patients. However, research on the association between Type D personality and cardiovascular events in couples is limited. This study investigated the correlation between Type D personality and cardiovascular outcomes among CAD patients and their spouses.

Design, Synthesis and Crystal Structure of a Novel Fluorescence Probe for Zn Based on Pyrano[3,2-c] Carbazole.

Zinc is a trace element, which plays an important role in many biological processes. The deficiency of zinc will lead to many diseases. Thus, it is of great significance to develop fast and efficient quantitative detection technology for zinc ions.

Preparation of carboxymethyl cellulose membrane flexible SERS substrate and its application in the detection of metabolites and pH in urine.

Uric acid, urea, and other metabolites in urine after exercise often reflect chronic injury syndrome in athletes. However, traditional urine detection methods have issues such as high costs and low detection sensitivity. SERS can rapidly, continuously, and sensitively monitor metabolites in human urine.

Roles of posttranslational modifications in lipid metabolism and cancer progression.

Lipid metabolism reprogramming has emerged as a hallmark of malignant tumors. Lipids represent a complex group of biomolecules that not only compose the essential components of biological membranes and act as an energy source, but also function as messengers to integrate various signaling pathways. In tumor cells, de novo lipogenesis plays a crucial role in acquiring lipids to meet the demands of rapid growth.

Which is the safer option for adult patients between peripherally inserted central catheters and midline catheters: a meta-analysis.

Background: Peripherally inserted central catheters (PICC) and midline catheters (MC) are widely used for intravenous infusions in oncology and critically ill patients. However, controversy remains regarding which method is superior. This meta-analysis systematically compares the safety differences between these 2 methods of intravenous catheterization.

Simulation of Defoliation Effects on Relay Strip Intercropping Soybean: Elucidating Foliar Shedding and Leaf-to-Nodule Growth Plasticity.

Extensive foliar shedding in monoculture soybeans post-anthesis negatively impacts yield, whereas relay strip intercropping prolongs leaf area duration, enhancing productivity. However, little is known about the causes of leaf shedding in monoculture and its impact on physiological functions and plasticity of source and sink organs, we conducted a 4-year field experiment and leaf-removal simulations in relay intercropped soybeans. Results revealed that monoculture soybeans experienced severe self-shading and defoliation, while relay intercropping maintained better light conditions, supporting higher leaf area, nodule numbers, and carbon allocation.

The complete genome sequence of Streptomyces sp. FIM 95-F1, a marine actinomycete that produces the antifungal antibiotic scopafungin.

Streptomyces FIM95-F1, an actinomycete originating from mangroves of Quanzhou bay, exhibits the capability to produce the antifungal antibiotic scopafungin. Here, the complete genome of Streptomyces sp. FIM95-F1 is presented with a GC content of 71.

Efficacy and safety of subcutaneous injection of botulinum toxin in the treatment of Chinese postherpetic neuralgia compared to analgesics: a systematic review of randomized controlled trials and meta-analysis.

Objective: The purpose of this meta-analysis is to investigate the efficacy and safety of a subcutaneous injection of botulinum toxin in the treatment of postherpetic neuralgia (PHN) compared to analgesics.

Methods: We searched PubMed, Cochrane Library, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang for randomized controlled trials (RCTs) from inception to 10 September 2023. The primary clinical outcomes included visual analog scale (VAS) pain scores and clinical effective rates.

Alternative splicing of VRF1 acts as a molecular switch to regulate stress-induced early flowering.

Plants frequently evade extreme environmental stress by initiating early flowering, yet the underlying mechanisms remain incompletely understood. Here, through extensive mutant screening, we identify a vegetative growth to reproductive growth transition factor (vrf1) mutant, which exhibits a deficiency in drought escape. Alternative splicing of VRF1 generates four isoforms, of which two encode functional proteins, VRF1-AS1 and VRF1-AS3.

Relay strip intercropping of soybeans and maize achieves high net ecosystem economic benefits by boosting land output and alleviating greenhouse gas emissions.

Background: Cereal-legume intercropping provides a solution for achieving global food security, but the mechanism of greenhouse gas emissions and net ecosystem economic benefits of maize-soybean relay intercropping are poorly understood. Hence, we conducted a two-factor experiment to investigate the effects of cropping systems, containing maize-soybean relay intercropping (IMS), monoculture maize (M) and monoculture soybean (S), as well as three nitrogen levels at 0 (N0), 180 (N1), 240 (N2) kg N ha on crop grain yield, greenhouse gas emissions, soil carbon stock and net ecosystem economic benefit (NEEB).

Results: The average grain yield of IMS (7.

Validating the CogSleep Screener in older adults at a memory and cognition clinic.

While sleep disturbances are prevalent in older people and are linked with poor health and cognitive outcomes, screening for the range of sleep disturbances is inefficient and therefore not ideal nor routine in memory and cognition clinic settings. We aimed to develop and validate a new brief self-report questionnaire for easy use within memory and cognition clinics. The design for this study was cross-sectional.

Differential Selectivity of Human and Mouse ABCC4/Abcc4 for Arsenic Metabolites.

Millions of people globally are exposed to the proven human carcinogen arsenic at unacceptable levels in drinking water. In contrast, arsenic is a poor rodent carcinogen, requiring >100-fold higher doses for tumor induction, which may be explained by toxicokinetic differences between humans and mice. The human ATP-binding cassette subfamily C (ABCC) transporter hABCC4 mediates the cellular efflux of a diverse array of metabolites, including the glutathione (GSH) conjugate of the highly toxic monomethylarsonous acid (MMA), monomethylarsenic diglutathione [MMA(GS)], and the major human urinary arsenic metabolite dimethylarsinic acid (DMA).

Microfluidics, an effective tool for supporting phage display-A review.

Phage display is a vital tool for the discovery and development of affinity reagents such as antibodies and peptides, which have great potential in imaging, molecular recognition, biosensors, targeted delivery and other clinical applications. However, affinity reagents obtained by phage display are often subjected to a process called biopanning, which is considered time-consuming, labor-intensive and lacks accurate control, limiting the acquisition of high-quality affinity reagents. Over the last two decades, several microfluidic approaches have been designed to simplify the conventional biopanning process and to realize precise control.