N6-methyladenosine RNA methylation, a new hallmark of metabolic reprogramming in the immune microenvironment.

N6-methyladenosine is one of the most common and reversible post-transcriptional modifications in eukaryotes, and it is involved in alternative splicing and RNA transcription, degradation, and translation. It is well known that cancer cells acquire energy through metabolic reprogramming to exhibit various biological behaviors. Moreover, numerous studies have demonstrated that m6A induces cancer metabolic reprogramming by regulating the expression of core metabolic genes or by activating metabolic signaling pathways.

FADD cooperates with Caspase-8 to positively regulate the innate immune response and promote apoptosis following bacterial infection in Japanese eel.

Fas-associated protein with Death Domain (FADD) is a crucial signaling component of apoptosis and a vital immunomodulator on inflammatory signaling pathways. However, information on FADD-mediated apoptosis and immune regulation is limited in teleost. We herein cloned a FADD homolog, AjFADD, from Japanese eel (Anguilla japonica).

Preoperative prediction of lymph node metastasis in intrahepatic cholangiocarcinoma: an integrative approach combining ultrasound-based radiomics and inflammation-related markers.

Objectives: To develop ultrasound-based radiomics models and a clinical model associated with inflammatory markers for predicting intrahepatic cholangiocarcinoma (ICC) lymph node (LN) metastasis. Both are integrated for enhanced preoperative prediction.

Methods: This study retrospectively enrolled 156 surgically diagnosed ICC patients.

Development and validation of a predictive model for overall survival in esophageal squamous cell carcinoma post-esophagectomy: the role of lymph node metastatic Stations.

Background: Esophageal squamous cell carcinoma (ESCC) poses a substantial healthcare challenge, particularly in areas such as East Asia. The pathologic nodal (pN) stage of ESCC remains a controversial factor. Accurately predicting overall survival (OS) after esophagectomy is crucial for treatment planning and improving treatment outcomes.

Shadow Effect-Triggered Photosensitive Gate of Organic Photoelectrochemical Transistor for Enhanced Biodetection.

The integration of a photosensitive gate into an organic electrochemical transistor has currently emerged as a promising route for biological sensing. However, the modification of the photosensitive gate always involves complex processes, and the degradation of sensitivity of the functional materials under illumination will significantly decrease the stability of the devices. Herein, we designed an organic photoelectrochemical transistor (OPECT) biosensor employing horseradish peroxidase (HRP)@glucose oxidase (GOx)/Pt/n-Si as the photosensitive gate based on the "shadow effect".

DINOV2-FCS: a model for fruit leaf disease classification and severity prediction.

Introduction: The assessment of the severity of fruit disease is crucial for the optimization of fruit production. By quantifying the percentage of leaf disease, an effective approach to determining the severity of the disease is available. However, the current prediction of disease degree by machine learning methods still faces challenges, including suboptimal accuracy and limited generalizability.

Long-term outcomes of intrathoracic vs. cervical anastomosis post-esophagectomy: a large-scale propensity score matching analysis.

Background: Esophageal squamous cell carcinoma (ESCC) is a prevalent and aggressive gastrointestinal tumor, particularly in East Asia. However, there is a lack of consensus on the long-term survival outcomes of intrathoracic anastomosis and cervical anastomosis following esophagectomy. This study aims to provide a comprehensive summary of the long-term survival outcomes of these two anastomosis techniques.

Protective effect of Huanglian Pingwei San on DSS-induced ulcerative colitis in mice through amelioration of the inflammatory response and oxidative stress.

Introduction: Ulcerative colitis (UC) results in the breakdown of the mucosal barrier caused by persistent inflammation and oxidative stress. Huanglian Pingwei San (HLPWS) is a commonly prescribed traditional Chinese medicine for treating colitis, but the precise mechanism remains unclear. The aim of this study was to systematically investigate the protective effect of HLPWS on UC mice and to elucidate the underlying mechanisms involved.

Comprehensive analysis of the prognostic and immunological role of cavins in non-small cell lung cancer.

Caveolae, specialized and dynamic subdomains of the plasma membrane, have a crucial role in diverse cellular functions encompassing endocytosis, signal transduction, mechanosensation, lipid storage, and metabolism. Cavin family proteins are indispensable for caveolar formation and function. An increasing number of studies have found that cavins are involved in tumor growth, invasion, metastasis, and angiogenesis and may have dual roles in the regulation of cancer.

Comparison of Intratumoral and Peritumoral Deep Learning, Radiomics, and Fusion Models for Predicting KRAS Gene Mutations in Rectal Cancer Based on Endorectal Ultrasound Imaging.

Main Objectives: We aimed at comparing intratumoral and peritumoral deep learning, radiomics, and fusion models in predicting KRAS mutations in rectal cancer using endorectal ultrasound imaging.

Methods: This study included 304 patients with rectal cancer from Fujian Medical University Union Hospital. The patients were randomly divided into a training group (213 patients) and a test group (91 patients) at a 7:3 ratio.

FUNDC1 predicts Poor Prognosis and promotes Progression and Chemoresistance in Endometrial Carcinoma.

Absence of effective prognostic biomarkers and therapeutic targets for reversing chemoresistance of endometrial carcinoma (EC) remains a huge challenge for clinicians. Mitophagy plays a crucial role in carcinogenesis and chemoresistance. FUN14 domain-containing protein 1 (FUNDC1) is a novel mitophagy receptor protein involved in tumorigenesis under hypoxic conditions.

Spatial confinement growth of high-performance persistent luminescence nanoparticles for image-guided sonodynamic therapy.

Near-infrared (NIR) persistent luminescence nanoparticles (PLNPs) have significant potential in diagnostic and therapeutic applications owing to their unique persistent luminescence (PersL). However, obtaining high-performance NIR PLNPs remains challenging because of the limitations of current synthesis methods. Herein, we introduce a spatial confinement growth strategy for synthesizing high-performance NIR PLNPs using hollow mesoporous silica (hmSiO).

[Impact of Change in Meteorological Conditions on PM Air Quality Improvement in Beijing-Tianjin-Hebei Region Using Process Analysis].

The air quality has significantly improved since the implementation of the Air Pollution Prevention and Control Action Plan in 2013. The effect of meteorological conditions on air quality improvement is complex, including affecting the emission, transport, diffusion, chemical transformation, and other processes of air pollutants. Based on the WRF-CMAQ model and process analysis （PA） tool, this study evaluates the impact of meteorological factor changes on the improvement of PM concentration in the Beijing-Tianjin-Hebei Region from 2013 to 2020 and further analyzes the role of meteorological conditions on the diffusion, transport, and transformation of atmospheric pollutants.

Novel chitosan/lignin hydrogel prepared by the Mannich reaction for Pb(II) and Cu(II) removal from aqueous solution.

Green and high-performance biomass-based adsorbents have a good application prospect for the removal of heavy metals. At present, the preparation of chitosan/lignin biomass adsorbents mainly adopts dissolution-drying method, and the obtained adsorbents show relatively poor adsorption performance for heavy metals. To overcome this problem, a novel chitosan/lignin hydrogel (CSL) is prepared by a simple one-pot method through the Mannich reaction.

Triboelectric nanogenerator for high-entropy energy, self-powered sensors, and popular education.

Triboelectric nanogenerator (TENG) has become a promising option for high-entropy energy harvesting and self-powered sensors because of their ability to combine the effects of contact electrification and electrostatic induction to effectively convert mechanical energy into electric power or signals. Here, the theoretical origin of TENG, strategies for high-performance TENG, and its applications in high-entropy energy, self-powered sensors, and blue energy are comprehensively introduced on the basis of the fundamental science and principle of TENG. Besides, a series of work in popular science education for TENG that includes numerous scientific and technological products from our science education base, Maxwell Science+, is emphatically introduced.

Research Progress in Strategies for Enhancing the Conductivity and Conductive Mechanism of LiFePO Cathode Materials.

LiFePO is a cathode material for lithium (Li)-ion batteries known for its excellent performance. However, compared with layered oxides and other ternary Li-ion battery materials, LiFePO cathode material exhibits low electronic conductivity due to its structural limitations. This limitation significantly impacts the charge/discharge rates and practical applications of LiFePO.

Differentially Expressed Genes and Alternative Splicing Analysis Revealed the Difference in Virulence to American Eels (Anguilla rostrata) Infected by Edwardsiella anguillarum and Aeromonas hydrophila.

Edwardsiella anguillarum and Aeromonas hydrophila are two common bacterial pathogens affecting cultivated eels, and the differences in their virulence remain unclear. In this study, after two groups of American eels (Anguilla rostrata) were administered the LD dose of E. anguillarum and A.

Comparative analysis of manual vs. mechanical suturing techniques in esophagectomy: A propensity score‑matched study of long‑term outcomes.

Esophageal cancer, particularly esophageal squamous cell carcinoma (ESCC), is a major health concern worldwide, particularly in China. Surgical resection is still considered the primary curative treatment for this disease. However, the effect of different surgical methods-traditional hand-sewn anastomosis and modern mechanical anastomosis-remains controversial.

NAT10 promotes liver lipogenesis in mouse through N4-acetylcytidine modification of Srebf1 and Scap mRNA.

Background: Metabolic dysfunction associated steatotic liver disease (MASLD), closely linked to excessive lipogenesis, induces chronic liver disease. MASLD often cause other metabolic diseases, such as cardiovascular disease, diabetes and obesity. However, the mechanism of N-acetyltransferase 10 (NAT10)-mediated N4-acetylcytidine (ac4C) mRNA modification in lipogenesis of MASLD has not been fully elucidated.

Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways.

Hormone therapy resistance and the ensuing aggressive tumor progression present a significant clinical challenge. However, the mechanisms underlying the induction of tumor malignancy upon inhibition of steroid hormone signaling remain poorly understood. Here, we demonstrate that Drosophila malignant epithelial tumors show a similar reduction in ecdysone signaling, the main steroid hormone pathway.