SMART: Development and Application of a Multimodal Multi-organ Trauma Screening Model for Abdominal Injuries in Emergency Settings.

Rationale And Objectives: Effective trauma care in emergency departments necessitates rapid diagnosis by interdisciplinary teams using various medical data. This study constructed a multimodal diagnostic model for abdominal trauma using deep learning on non-contrast computed tomography (CT) and unstructured text data, enhancing the speed and accuracy of solid organ assessments.

Materials And Methods: Data were collected from patients undergoing abdominal CT scans.

A simple and efficient method for separation of Tc from Mo targets.

Tc is regarded as the most important medical isotope, and its supply issues have garnered significant attention. A simple and efficient separation method was performed for the production of Tc from Mo target in this study. The entire process involves accelerator irradiation, Tc/Mo separation, and target material recovery.

Xinglou Chengqi Decoction Protects against Cerebral Ischemia/Reperfusion Injury by Inhibiting Ferroptosis via SLC7A11/GPX4 Signaling.

Xinglou Chengqi decoction (XLCQD) is a Chinese formula that offers benefits in ischemic stroke. However, the underlying mechanism of the effects of XLCQD-mediated anti-ischemic stroke effects remains obscure. This study investigates the ferroptosis mechanism of XLCQD against cerebral ischemia/reperfusion (I/R) injury using rat models of middle cerebral artery occlusion/reperfusion (MCAO/R).

Heyingwuzi formulation alleviates diabetic retinopathy by promoting mitophagy the HIF-1α/BNIP3/NIX axis.

Background: Diabetic retinopathy (DR) is the primary cause of visual problems in patients with diabetes. The Heyingwuzi formulation (HYWZF) is effective against DR.

Aim: To determine the HYWZF prevention mechanisms, especially those underlying mitophagy.

Single cells and TRUST4 reveal immunological features of the HFRS transcriptome.

The etiology of hemorrhagic fever with renal syndrome (HFRS) is significantly impacted by a variety of immune cells. Nevertheless, the existing techniques for sequencing peripheral blood T cell receptor (TCR) or B cell receptor (BCR) libraries in HFRS are constrained by both limitations and high costs. In this investigation, we utilized the computational tool TRUST4 to generate TCR and BCR libraries utilizing comprehensive RNA-seq data from peripheral blood specimens of HFRS patients.

Trilobatin suppresses aging-induced cognitive impairment by targeting SIRT2: Involvement of remodeling gut microbiota to mediate the brain-gut axis.

Background: Aging is associated with learning and memory disorder, affecting multiple brain areas, especially the hippocampus. Previous studies have demonstrated trilobatin (TLB), as a natural food additive, can extend the life of Caenorhabditis elegans and exhibit neuroprotection in Alzheimer's disease mice. However, the possible significance of TLB in anti-aging remains elusive.

Energy Efficient Carbon Capture through Electrochemical pH Swing Regeneration of Amine Solution.

Carbon capture is widely acknowledged as a promising strategy for achieving negative emissions. Electrochemical carbon capture technologies are considered a viable alternative to conventional temperature swing processes. Among these, employing the hydrogen oxidation and hydrogen evolution reactions as a redox couple, along with an ion exchange membrane, offers an effective means of establishing a pH swing for desorbing CO and regenerating the alkaline solvent.

Comprehensive analysis of juvenile idiopathic arthritis patients' immune characteristics based on bulk and single-cell sequencing data.

Background: The pathogenesis of juvenile idiopathic arthritis (JIA) is strongly influenced by an impaired immune system. However, the molecular mechanisms underlying its development and progression have not been elucidated. In this study, the computational methods TRUST4 were used to construct a T-cell receptor (TCR) and B-cell receptor (BCR) repertoire from the peripheral blood of JIA patients bulk RNA-seq data, after which the clonality and diversity of the immune repertoire were analyzed.

SIRT1/P53 in retinal pigment epithelial cells in diabetic retinopathy: a gene co-expression analysis and He-Ying-Qing-Re formula treatment.

Objective: Diabetic retinopathy (DR) is a severe diabetic complication that leads to severe visual impairment or blindness. He-Ying-Qing-Re formula (HF), a traditional Chinese medicinal concoction, has been identified as an efficient therapy for DR with retinal vascular dysfunction for decades and has been experimentally reported to ameliorate retinal conditions in diabetic mice. This study endeavors to explore the therapeutic potential of HF with key ingredients in DR and its underlying novel mechanisms.

Benralizumab efficacy and safety in severe asthma: A randomized trial in Asia.

Background: Benralizumab is indicated as add-on therapy in patients with uncontrolled, severe eosinophilic asthma; it has not yet been evaluated in a large Asian population with asthma in a clinical trial.

Objective: To evaluate the efficacy and safety of benralizumab in patients with severe asthma in Asia.

Methods: MIRACLE (NCT03186209) was a randomized, Phase 3 study in China, South Korea, and the Philippines.

Benzodiazepine use in medical cannabis authorization adult patients from 2013 to 2021: Alberta, Canada.

Background: Benzodiazepines are a class of medications that are being frequently prescribed in Canada but carry significant risk of harm. There has been increasing clinical interest on the potential "sparing effects" of medical cannabis as one strategy to reduce benzodiazepine use. The objective of this study as to examine the association of medical cannabis authorization with benzodiazepine usage between 2013 and 2021 in Alberta, Canada.

Acute lupus pneumonitis resembling miliary tuberculosis: A case-based review.

Systemic lupus erythematosus (SLE) is an autoimmune disease involving multiple systems and organs, with pulmonary involvement known to be associated with disease prognosis and mortality. Acute lupus pneumonitis (ALP) resembling miliary tuberculosis (TB) is rare. Here, we present a case of ALP mimicking miliary TB and review the literature.

Association between Sleep Duration and Left Ventricular Hypertrophy for Patients with Type 2 Diabetes Mellitus.

Objective: In this study, we aimed to estimate the impact of sleep duration on left ventricular hypertrophy (LVH) in type 2 diabetes mellitus (T2DM).

Methods: Consecutive patients with T2DM undergoing transthoracic echocardiography (TTE) in our center from October 2017 to February 2021 were analyzed. The association of the risk of LVH in T2DM patients was evaluated using univariable and multivariable logistic regression analyses.

Relationship between serum uric acid levels and osteoporosis.

Osteoporosis (OP) is a systemic bone disease in which bone density and quality decrease and bone fragility increases due to a variety of causes, making it prone to fractures. The development of OP is closely related to oxidative stress. Uric acid (UA) is the end product of purine metabolism in the human body.

Optimization of target system for the production of Mo via Mo(γ,n)Mo reaction.

With an increase of stopping operation of nuclear reactors worldwide, the supply of medical Mo becomes difficult and thus many efforts have been made to find an alternative. A process based on an electron linear accelerator (linac) system and aMo target via the Mo (γ,n)Mo reaction receives a lot of attention due to the relatively low level of co-produced impurities. This process has been recently developed at the Institute of Modern Physics (IMP) and the Monte Carlo simulation was used to optimize the target system before operating pilot irradiation experiments.

Study on material and mechanical characteristics of silicone rubber shed of field-aged 110 kV composite insulators.

Composite insulators have excellent performance and are more and more widely used in power grid. The performance of composite insulators with different service duration will decline in varying degrees, which could pose a threat to the safe operation of power grid. In order to investigate the influence of service duration and electric field strength on insulator shed performance, the sheds at different positions of insulators with different service duration are sampled.

Evaluating the prevalence of lipid assessments in children in Alberta, Canada.

Background: Familial hypercholesterolemia is a common, inherited, life-threatening and treatable condition that is characterized by marked elevations of low-density lipoprotein cholesterol (LDL-C), resulting in a high risk of cardiovascular disease, but treatment starting in childhood dramatically reduces this risk. We sought to evaluate the prevalence of pediatric lipid assessments among children in Alberta.

Methods: We reviewed laboratory and administrative data from Alberta Health between Apr.

Trilobatin attenuates cerebral ischaemia/reperfusion-induced blood-brain barrier dysfunction by targeting matrix metalloproteinase 9: The legend of a food additive.

Background And Purpose: Blood-brain barrier (BBB) breakdown is one of the crucial pathological changes of cerebral ischaemia-reperfusion (I/R) injury. Trilobatin (TLB), a naturally occurring food additive, exerts neuroprotective effects against cerebral I/R injury as demonstrated in our previous study. This study was designed to investigate the effect of TLB on BBB disruption after cerebral I/R injury.

Choice of Oral Anticoagulant: Outcomes in Atrial Fibrillation Patients Post-Stroke Despite Direct Oral Anticoagulant Use.

Background: For patients with atrial fibrillation who have an ischemic stroke or transient ischemic attack (TIA) despite taking direct oral anticoagulants (DOACs), the optimal strategy for ongoing anticoagulation is unknown.

Methods: Using provincial administrative databases in Alberta, Canada, we compared anticoagulant use before/after the breakthrough stroke/TIA and assessed recurrence of stroke/TIA or bleeding, with consideration of medication adherence. Adherence was defined as the proportion of days covered (PDC) being ≥ 80%.

The Efficacy of Tranexamic Acid in Craniomaxillofacial Surgery: A Systematic Review of Randomized Controlled Trials.

This study aimed to evaluate the use of tranexamic acid in craniomaxillofacial surgery by meta-analysis. A comprehensive search was performed for randomized controlled trials (RCTs) mainly in 3 electronic databases (PubMed, EMBASE, and Cochrane Library) before August 2022. We collected and managed data for weighted mean difference of intraoperative blood loss, transfusion requirement, and operation time for the study.

Hu-Zhang Qing-Mai Formulation anti-oxidative stress alleviates diabetic retinopathy: Network pharmacology analysis and in vitro experiment.

Background: In this study, the potential mechanism of the Hu-Zhang Qing-Mai Formulation (HZQMF) on diabetic retinopathy (DR) in inhibiting oxidative stress was explored through network pharmacology analysis and in vitro experiments.

Methods: The Traditional Chinese Medicine Systematic Pharmacology Analysis Platform was used to retrieve the active pharmaceutical ingredients and targets of HZQMF. DR-related genes and oxidative stress-related genes were obtained from PharmGKB, TTD, OMIM, GeneCards, and Drugbank.

Record-breaking marine heatwave in northern Yellow Sea during summer 2018: Characteristics, drivers and ecological impact.

Globally, marine heatwaves (MHWs) are becoming more common, more intense, and longer-lasting. They could have a large ecological and societal impact when compounded by low oxygen concentrations or high acidity. Here, using a high-resolution satellite product and reanalysis datasets, we investigated the characteristics of the MHW at northern Yellow Sea (NYS) during mid-summer 2018 and the driving mechanisms of large-scale atmospheric circulations.