Elevation of ANXA1 associated with potential protective mechanism against ferroptosis and immune cell infiltration in age-related macular degeneration.

Background: Age-related macular degeneration (AMD), is a neurodegenerative ocular disease. This study investigated the role of ferroptosis-related genes and their interaction with immune cell infiltration in AMD.

Methods: We screened differential expression genes (DEGs) of AMD from data sets in Gene Expression Omnibus.

Advancing Succinic Acid Biomanufacturing Using the Nonconventional Yeast .

Succinic acid is an essential bulk chemical with wide-ranging applications in materials, food, and pharmaceuticals. With the advancement of biotechnology, there has been a surge in focus on low-carbon sustainable microbial synthesis methods for producing biobased succinic acid. Due to its high intrinsic acid tolerance, has gained recognition as a competitive chassis for the industrial manufacture of succinic acid.

Bibliometric and visual analysis of medication therapy management from 2003 to 2023.

Medication therapy management (MTM) includes various clinical pharmacy services that greatly influence society and economy. Despite extensive research in recent years, there is currently a lack of bibliometric analysis on this subject. Articles and reviews on MTM published from 2003 to 2023 were identified and selected from the Web of Science Core Collection.

Comprehensive analysis of skin growth-related hub genes and microenvironment characterization in a mouse expanded skin model.

Background: Mechanical stretch-mediated tissue expansion is effective for obtaining extra skin and soft tissue required for the repair of defects or reconstruction of surface organs. Understanding the cellular and molecular mechanisms and identifying hub genes and key cell types associated with skin expansion could help predict the success of skin growth during expansion procedures.

Methods: We analyzed murine chip sequencing data and single-cell sequencing data available from the Gene Expression Omnibus database.

The GRAS gene family and its roles in pineapple (Ananas comosus L.) developmental regulation and cold tolerance.

Background: Pineapple (Ananas comosus L.) is a major tropical fruit crop with considerable economic importance, and its growth and development are significantly impacted by low temperatures. The plant-specific GRAS gene family plays crucial roles in diverse processes, including flower and fruit development, as well as in stress responses.

Akkermansia muciniphila activates natural killer cells by suppressing the TGF-β signaling pathway in lung adenocarcinoma cells.

Lung adenocarcinoma (LUAD) stands out as a prevalent malignant tumor necessitating innovative strategies to enhance therapeutic outcomes. Akkermansia muciniphila (AKK) has emerged as intricately linked to tumor immunotherapy, yet its impact on natural killer (NK) cells, which play a crucial role in immunotherapy, remains unclear. This study aims to investigate the effects of AKK outer membrane proteins on NK cells in LUAD and elucidate potential associated molecular mechanisms.

Prognostic value of left atrial strain in patients with stage II light-chain cardiac amyloidosis receiving cardiac magnetic resonance imaging: a prospective cohort study.

Background: The prognostic significance of left atrial (LA) dysfunction in cardiac amyloidosis is being increasingly acknowledged, but its importance in stage II light-chain cardiac amyloidosis (AL-CA) remains unclear. This study aimed to determine the prognostic value of LA strain in stage II AL-CA.

Methods: Patients with stage II AL-CA who underwent cardiac magnetic resonance at Peking Union Medical College Hospital between January 1, 2015, and October 31, 2021, were consecutively enrolled in this cohort study.

Disorder-specific neurodynamic features in schizophrenia inferred by neurodynamic embedded contrastive variational autoencoder model.

Neurodynamic models that simulate how micro-level alterations propagate upward to impact macroscopic neural circuits and overall brain function may offer valuable insights into the pathological mechanisms of schizophrenia (SCZ). In this study, we integrated a neurodynamic model with the classical Contrastive Variational Autoencoder (CVAE) to extract and evaluate macro-scale SCZ-specific features, including subject-level, region-level parameters, and time-varying states. Firstly, we demonstrated the robust fitting of the model within our multi-site dataset.

NF-κB/Relish readjusts miR-100 expression and recovers immune homeostasis in Drosophila melanogaster.

The regulation and maintenance of immune homeostasis are essential for animal survival, but the molecular mechanisms are not fully understood. Here, we used the model organism Drosophila melanogaster to uncover a potential mechanism by which the nuclear factor-κB transcription factor Relish and miR-100 cooperatively regulate innate immune homeostasis. We first demonstrated in vitro and in vivo that miR-100 can negatively regulate the immune responses of the Imd pathway by inhibiting the expression of TAK1-associated binding protein 2 (Tab2) gene.

Integrated Care Services for Dementia and Their Challenges from a Nursing Home Perspective: An Ethnographic Study.

Background: The number of older adults living with dementia is increasing in China and worldwide. There is limited attention paid to dementia care in nursing homes, and this study aimed to explore the current situation and challenges of providing integrated care services in nursing home settings.

Methods: A 3-month focused ethnographic study, including semi-participatory observations and in-depth interviews, was conducted in a nursing home in Suzhou, China, from June to August 2022.

Comprehensive prognosis assessment of cardiovascular magnetic resonance parametric mapping in light chain amyloidosis.

Background: Recent evidence underlined the importance of cardiovascular magnetic resonance (CMR) in light chain amyloidosis (AL amyloidosis). We aimed to comprehensively assess the prognostic significance of CMR parametric mapping in AL amyloidosis.

Methods: This prospective study consecutively included AL amyloidosis patients who underwent CMR imaging before therapy.

Effect of archwire size and lever arm length on anterior and posterior teeth movement during en-masse retraction in personalized lingual orthodontics: A 3-dimensional finite element study.

Objective: To evaluate the biomechanical effect of anterior and posterior teeth in en-masse retraction in lingual orthodontics using varied archwire sizes and lever arm lengths.

Methods: A finite element model of lingual orthodontics for retracting maxillary anterior teeth was established. The archwire was designed into: Archwire 1: 0.

Coordination strategy and contract design of platform supply chain for large-scale sports events with low carbon preference.

The organization of sports events, while generating economic benefits, inevitably imposes significant environmental pressures. Conducting green and low-carbon sports events have become a global consensus. In addressing the carbon emissions and benefit coordination issues on the production end of infrastructure construction for large-scale sports events, we considers the significant role of digital platforms in the industry's low-carbon transformation and upgrade, and innovatively incorporates platforms as decision-making entities and investigates the equilibrium strategies for low-carbon cooperation under three different power structures: one led by the sports events materials supplier, one by the materials distributor, and one by the integrated service platform.

Brain-clinical pattern alterations after treatment in schizophrenia.

Discovering meaningful brain-clinical patterns would be a significant advancement for elucidating the pathophysiology underlying schizophrenia. In the present study, we analyzed associations between functional brain characters (average functional connectivity strength and its fluctuations) and clinical features (age onset, illness duration, and positive, negative, disorganized, excited, and depressed) using partial least squares. Also, we analyzed the brain-clinical relationship changes after 6-wk of treatment.

The Association between Serum Lipid Profile Levels and Hypertension Grades: A Cross-Sectional Study at a Health Examination Center.

Introduction: Hypertension and dyslipidemia are major cardiovascular risk factors that often coexist. Hyperlipidemia is a crucial modifiable risk factor in preventing cardiovascular disease.

Aim: We aimed to explore the relationship between lipid levels and the grading of hypertension in a community-based adult population.

Low-Valent Tungsten Catalyzed Carbonylative Synthesis of Benzoates from Aryl Iodides and Alcohols.

Non-noble metals catalyzed carbonylative reactions serve as straightforward and sustainable methods for the synthesis of functionalized carbonyl-containing compounds. Herein, a low-valent-tungsten-catalyzed reaction that enables the coupling of aryl iodides and alcohols or phenols was disclosed, employing the readily available W(CO) as the effective catalyst and PPh as ligand. Under the optimal reaction conditions, aryl iodides smoothly underwent carbonylative coupling reactions with alcohols or phenols, processing the feature of broad substrate scope and good functional groups tolerance.

Systematic metabolic engineering of for efficient production of phytohormone abscisic acid.

Abscisic acid (ABA) is an important phytohormone with diverse applications. It currently relies on the fermentation of , which suffers from limited availability of genetic engineering tools. Here, was engineered to enable biosynthesis of ABA.

Development and validation of an interpretable machine learning model for predicting the risk of distant metastasis in papillary thyroid cancer: a multicenter study.

Background: The survival rate of patients with distant metastasis (DM) of papillary thyroid carcinoma (PTC) is significantly reduced. It is of great significance to find an effective method for early prediction of the risk of DM for formulating individualized diagnosis and treatment plans and improving prognosis. Previous studies have significant limitations, and it is still necessary to develop new models for predicting the risk of DM of PTC.