The fucoidan delivery system enhanced the anti-cervical cancer effect of caffeic acid.

Cervical cancer remains one of the leading causes of mortality among women, and immunotherapy targeting the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway holds promise for its treatment. This study has developed nanoparticles based on fucoidan (Fu/CA NPs), successfully loading them with caffeic acid (CA) for application in cervical cancer therapy. In vitro experiments revealed that Fu/CA NPs significantly inhibited the proliferation of cervical cancer HeLa cells (by 65.

Prognostic value of glycolipid metabolism index on complications and mechanical ventilation in intensive care unit patients with intracerebral hemorrhage: a retrospective cohort study using the MIMIC-IV database.

Objective: This study aimed to evaluate the predictive capability of glycolipid metabolism index (triglyceride-glucose index, TyG; atherogenic index of plasma, AIP; triglyceride to high-density lipoprotein cholesterol ratio, TG/HDL-C; and non-HDL-C to HDL-C ratio, NHHR) for complications and ventilator use in patients with intracerebral hemorrhage (ICH) admitted to the intensive care unit (ICU).

Methods: Patients with ICH requiring ICU admission were selected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Outcomes assessed included incidence of complications and use of ventilator support.

Antitumor Activity of USP7 Inhibitor GNE-6776 in Non-Small Cell Lung Cancer Involves Regulation of Epithelial-Mesenchymal Transition, Cell Cycle, Wnt/β-Catenin, and PI3K/AKT/mTOR Pathways.

Non-small cell lung cancer (NSCLC) is a major cause of cancer-related deaths worldwide. This study investigated the effects and mechanisms of the USP7 inhibitor GNE-6776 on human NSCLC A549 and H1299 cells, providing insights for anti-NSCLC drug development. USP7 expression was analyzed in lung cancer tissue using data from public databases.

Olfactory mucosa mesenchymal stem cell-derived exosomes protect against neuroinflammation after subarachnoid hemorrhage by activating mitophagy.

Subarachnoid hemorrhage (SAH) can lead to significant acute neuroinflammation, with treatment outcomes often being inadequate. Olfactory mucosa mesenchymal stem cells (OM-MSCs) have promising therapeutic potential in nerve regeneration and functional recovery. This investigation sought to elucidate the functional mechanisms through which exosomes derived from OM-MSCs provide protection against neuroinflammation following SAH.

Unconventional protein secretion: Exploring membrane proteins and beyond.

Protein secretion is essential for cellular communication and function, enabling the delivery of both soluble and integral membrane proteins to the extracellular space and the cell surface. While the classical endoplasmic reticulum (ER)-Golgi pathway has been extensively studied, emerging evidence highlights the existence of unconventional protein secretion (UcPS) pathways. Among these, the mechanisms that enable membrane proteins to bypass the Golgi apparatus remain poorly understood.

Trade-Off Between Enzymatic Antioxidant Defense and Accumulation of Organic Metabolite Affects Salt Tolerance of White Clover Associated with Redox, Water, and Metabolic Homeostases.

White clover () is an excellent perennial cold-season ground-cover plant for municipal landscaping and urban greening. It is, therefore, widely distributed and utilized throughout the world. However, poor salt tolerance greatly limits its promotion and application.

The Expression Regulation and Cancer-Promoting Roles of RACGAP1.

RACGAP1 is a Rho-GTPase-activating protein originally discovered in male germ cells to inactivate Rac, RhoA and Cdc42 from the GTP-bound form to the GDP-bound form. GAP has traditionally been known as a tumor suppressor. However, studies increasingly suggest that overexpressed RACGAP1 activates Rac and RhoA in multiple cancers to mediate downstream oncogene overexpression by assisting in the nuclear translocation of signaling molecules and to promote cytokinesis by regulating the cytoskeleton or serving as a component of the central spindle.

Soil microbiome bacteria protect plants against filamentous fungal infections via intercellular contacts.

Bacterial-fungal interaction (BFI) has significant implications for the health of host plants. While the diffusible antibiotic metabolite-mediated competition in BFI has been extensively characterized, the impact of intercellular contact remains largely elusive. Here, we demonstrate that the intercellular contact is a prevalent mode of interaction between beneficial soil bacteria and pathogenic filamentous fungi.

Activation of persulfates on carbon nanotubes for water decontamination: Is the non-radical process consistently considered across different pH levels?

Carbon nanotubes-driven persulfates oxidation processes (CNTs/PS) have been extensively studied for environmental remediation. Solution pH is one of the main factors affecting wastewater treatment, but it is often overlooked. Herein, we report the effect laws of pH on the mechanism of peroxymonosulfate (PMS) or peroxydisulfate (PDS) activation by CNTs.

Investigation of electromagnetic wave propagation characteristics across various frequencies in porous media of goaf.

The reliable long-distance transmission of electromagnetic wave signals within goaf is fundamental for the implementation of wireless monitoring and early warning systems for goaf-related disasters. This paper establishes an experimental platform for electromagnetic wave signal transmission within goaf and develops a propagation model for electromagnetic waves in the porous media of goaf. The transmission characteristics of electromagnetic waves at various frequencies within the porous media environment of goaf are investigated through experimental and numerical simulation approaches.

Risk factors and a prediction model of severe asparaginase-associated pancreatitis in children.

We aimed to investigate whether early clinical indicators were associated with eventual disease severity, and to develop a predictive model for severe asparaginase-associated pancreatitis (AAP). Seventy-five acute lymphoblastic leukaemia (ALL) cases with AAP admitted to Shanghai Children's Medical Center from March 2013 to August 2023 were divided into non-severe (n = 44) and severe (n = 31) groups based on Atlanta diagnostic and AAP grading criteria. We compared essential information, asparaginase(ASP) dosage form, cumulative dose, clinical characteristics and laboratory tests between the groups.

Eosinophilic gastroenteritis with hemorrhagic ascites: a case report.

Eosinophilic gastroenteritis (EGE) is an inflammatory disease characterized by a significant increase in eosinophils. EGE itself is rare, and cases with clinical manifestations of hemorrhagic ascites are even rarer, which undoubtedly increases the risk of misdiagnosis. Given this, this study reports a rare case of pediatric EGE presenting with paroxysmal abdominal pain without apparent cause, accompanied by acute tonsillitis and mesenteric lymphadenitis, suggesting a possible intestinal infection.

Specific Transcriptional Regulation Controls Plant Organ-Specific Infection by the Oomycete Pathogen Phytophthora sojae.

The organs of a plant species vary in cell structure, metabolism and defence responses. However, the mechanisms that enable a single pathogen to colonise different plant organs remain unclear. Here we compared the transcriptome of the oomycete pathogen Phytophthora sojae during infection of roots versus leaves of soybeans.

Nrf2 activator tertiary butylhydroquinone enhances neural stem cell differentiation and implantation in Alzheimer's disease by boosting mitochondrial function.

Aims: To investigate the effects of Nrf2 agonist tertiary butylhydroquinone (TBHQ)-stimulated neural stem cells (NSCs) transplantation (NSC(TBHQ)) on neuronal damage and cognitive deficits in an AD model and its underlying principles.

Methods: BHQ-treated NSCs were examined with or without Aβ1-42 to investigate the effects of TBHQ on the proliferation and differentiation functions. The mitophagy inhibitor Cyclosporine A (CSA) was used to explore the regulation of mitophagy by TBHQ.

Theoretical Calculation of Dissolved Gas in Transformer Oil Using the Gas Sensitive Properties of Sc- and Ti-Modified ZrS.

To guarantee the secure functioning of the complete power system and minimize the risks associated with oil-filled transformers during their operation, it is greatly important to carry out gas sensing studies of dissolved gases in transformer research. Through the utilization of first-principles density functional theory calculations, the adsorption energy, electronic characteristics, and recuperation duration of ZrS modified with Sc and Ti were examined. The results show that compared to those of the initial ZrS material, the doping of TM atoms Sc and Ti significantly improved the adsorption properties of the material, and the adsorption of CO and CH showed chemisorption.

Disrupting stroke-induced GAT-1-syntaxin1A interaction promotes functional recovery after stroke.

Although stroke is a frequent cause of permanent disability, our ability to promote stroke recovery is limited. Here, we design a small-molecule stroke recovery promoting agent that works by dissociating γ-aminobutyric acid (GABA) transporter 1 (GAT-1) from syntaxin1A (Synt1A), a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein. Stroke induces an increase in GAT-1-Synt1A interaction in the subacute phase, a critical period for functional recovery.

CrSe based single-cluster catalysts with controllable charge states for the oxygen reduction and hydrogen evolution reactions.

Development of affordable catalysts for the oxygen reduction reaction (ORR) and hydrogen evolution reaction (HER) represents a central task for advancing electrochemical systems such as fuel cells and metal-air batteries. This study reported the ORR and HER performance of a set of single cluster catalysts (SCCs) with atomically dispersed 3d/4d/5d transition metal cluster (TM) embedded in a two-dimensional (2D) defective CrSe substrate. Distinguishing from the conventional SCCs with positive charge active center, the unique electronegativity discrepancy between the metal clusters and the substrate renders the active center controllable charge states from negative to positive.

STC2 knockdown inhibits cell proliferation and glycolysis in hepatocellular carcinoma through promoting autophagy by PI3K/Akt/mTOR pathway.

Background: The pathogenesis exploration and timely intervention of hepatocellular carcinoma (HCC) are crucial due to its global impact on human health. As a general tumor biomarker, stanniocalcin 2 (STC2), its role in HCC remains unclear. We aimed to analyze the effect and mechanism of STC2 on HCC.

IL-1β-induced mesenchymal stem cell-derived exosomes inhibit neuronal ferroptosis in intracerebral hemorrhage through the HSPA5/GPX4 axis.

Background: Neuronal cell ferroptosis following intracerebral hemorrhage (ICH) is a crucial factor contributing to the poor prognosis of ICH patients. The objective of this investigation was to investigate the molecular mechanism of IL-1β-induced mesenchymal stem cell-derived exosomes (IL-1β-Exo) in mitigating ICH injury.

Methods: Exo and IL-1β-Exo were obtained and identified.

A Degradable Bioelectronic Scaffold for Localized Cell Transfection toward Enhancing Wound Healing in a 3D Space.

Large skin wounds, with extensive surface area and deep vertical full-thickness involvement, can pose significant challenges in clinical settings. Traditional routes for repairing skin wounds encompass three hallmarks: 1) scab formation for hemostasis; 2) proliferation and migration of epidermal cells for wound closure; 3) proliferation, migration, and functionalization of fibroblasts and endothelial cells for dermal remodeling. However, this route face remarkable challenges to healing large wounds, usually leading to disordered structures and loss of functions in the regenerated skin, due to limited control on the transition among the three stages.

Research on Depression in Children with Severe Bronchial Asthma: The Impact of Alexithymia and Somatic Symptoms.

Objective: The prevalence of depression in children with severe bronchial asthma is a significant concern due to its potential effects on illness burden and quality of life. This cross-sectional study aims to explore the relationship between depression and severe bronchial asthma in children, focusing on the impact of alexithymia and somatic symptoms.

Methods: The study includes a total of 186 children aged 6-14 years diagnosed with severe bronchial asthma between 2008 and 2022 in our institute.