Publications by authors named "Lin Li-Wei"

Article Synopsis
  • Esophageal achalasia is a condition that affects the lower esophageal sphincter (LES), leading to symptoms like difficulty swallowing, chest pain, and weight loss, with traditional treatments providing limited relief.
  • This study investigates the effectiveness of Traditional Chinese Medicine, specifically Coptis chinensis and its active component berberine, in promoting LES relaxation as a potential alternative treatment.
  • Results indicate that both C. chinensis extract and berberine significantly relax the LES by activating potassium channels, suggesting further research is warranted for their therapeutic use in esophageal disorders like achalasia.
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Purpose: Sitting Baduanjin exercises can be effective in treating mild cognitive impairment (MCI). However, evidence on effectiveness of sitting Baduanjin exercises is lacking. This study investigated the effects of sitting Baduanjin exercises on cognitive function, attention, and muscle strength in patients with MCI.

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Purpose: Postoperative delirium (POD) is a syndrome that often occurs after surgery. Nursing staff are the first-line personnel who have the most time and close contact with postoperative patients. If delirium is not recognized immediately, it will affect the patient's prognosis and increase clinical care requirements and health care costs.

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Colony stimulating factor-1 receptor (CSF1R or c-FMS), a class III receptor tyrosine kinase expressed on members of the mononuclear phagocyte system (MPS), plays a key role in the proper functioning of macrophages, microglia, and related cells. Aberrant signaling through CSF1R has been associated with a variety of disease states, including cancer, inflammation, and neurodegeneration. In this Letter, we detail our efforts to develop novel CSF1R inhibitors.

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Article Synopsis
  • Demodex mites, often debated for their harmful effects, are now linked to various skin and eye diseases, including rosacea and keratitis.
  • A unique case is reported where a 29-year-old male with preseptal cellulitis-like symptoms was found to have a Demodex mite infestation instead of a typical infection.
  • This case highlights the importance for doctors to consider Demodex mites as a possible cause of ocular issues, especially when standard treatments fail.
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Emissions from transportation fuel vehicles are polluting the environment more than ever before. Currently, autonomous delivery vehicles (ADVs) are welcomed by logistics service providers and lots of consumers in general for their significant contribution in reducing environmental pollution and increasing delivery efficiency. However, there is a lack of in-depth research on consumers' willingness to adopt ADVs, despite the fact that ADVs are innovative delivery method in the field of last-mile delivery.

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This study explored how the holiday effect impacts the fluctuations in various scale indexes. Using differential and double-difference methods, the researchers of this study analyzed the impact of the lockdown in Wuhan, China on the holiday effect during the COVID-19 pandemic. The research objects used in this study include CSI All Share, CNI1000, CNI 2000, CNI Large Cap.

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Introduction: Social media systems are instrumental in the dissemination of timely COVID-19 pandemic information to the general population and contribute to the fight against the pandemic and waves of disinformation during the COVID-19 pandemic. This study uses the information adoption model (IAM) as the theoretical framework to examine the moderating influence of perceived government information transparency on the adoption of COVID-19 pandemic information on social media systems from the Ghanaian perspective. Government information transparency regarding the pandemic is crucial since any lack of transparency can negatively affect the global response to the pandemic by destroying trust (in government and public health authorities/institutions), intensifying fears, and causing destructive behaviors.

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Background: Regurgitation is a complication common during cardiopulmonary resuscitation (CPR). This manikin study evaluated the effect of regurgitation during endotracheal intubation on CPR quality.

Methods: An airway-CPR manikin was modified to regurgitate simulated gastric contents into the oropharynx during chest compression during CPR.

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Airborne fine particulate matter (PM) is a severe problem and is associated with health issues including liver diseases. Workers performing manual labor tend to be alcohol consumers during work, where they are also exposed to PM. Long-term PM exposure can increase oxidative stress, leading to inflammation.

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Purpose: The purpose of this study is to examine the factors influencing China's new retail industry on corporate performance. We mainly design the adjustment effect of the internationalization of its new retail industry on corporate performance and proprietary assets.

Design/methodology/approach: The framework is based on dynamic panel data of 590 listed companies in China's new retail industry from 2007 to 2019.

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Background: The prevalence of dementia in Taiwan continues to rise, and related patient care is becoming challenging for family members and caregivers. Nondrug treatments are often used as a care strategy to alleviate the behaviors associated with worsening dementia. Many international researchers have examined the effectiveness of drama therapy on dementia care.

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Objective To study the correlation of B-type natriuretic peptide(BNP)level with hemodynamic parameters and inflammatory cytokines in patients with Gram-negative sepsis,and further determine the main factors for the significant increase of BNP level. Methods The prospective study method was applied,and septic patients infected with Gram-negative bacteria from May 2017 to October 2019 were enrolled.The patients were divided into the BNP<2400 ng/L group and the BNP≥2400 ng/L group by taking the average value of BNP as the dividing point.

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Background: Gastroesophageal reflux disease (GERD) is associated with lower esophageal sphincter (LES) incompetence. In some patients, GERD is refractory to acid reduction therapy which is the main treatment for GERD. So far, medications that can increase LES tone are few.

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Youth fountain and aging culprits are usually sought and identified in blood but not urine. Extracellular vesicles (EVs) possess parental cell properties, circulate in blood, CSF and urine, and provide paracrine and remote cell-cell communication messengers. This study investigated whether senescence-associated secretory phenotype (SASP) and immune defense factors in EVs of urine could serve as biomarkers in elderly individuals with and without a comorbidity.

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Classical high-throughput screening (HTS) technologies for the analysis of ionic currents across biological membranes can be performed using fluorescence-based, radioactive, and mass spectrometry (MS)-based uptake assays. These assays provide rapid results for pharmacological HTS, but the underlying, indirect analytical character of these assays can be linked to high false-positive hit rates. Thus, orthogonal and secondary assays using more biological target-based technologies are indispensable for further compound validation and optimization.

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Purpose: To investigate the influences of atropine on changes in anterior segment geometry, as measured by ultrasound biomicroscopy in children.

Methods: A prospective observational study was performed. Anterior segment parameters were obtained by UBM before and after the instillation of 1% atropine.

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The B-mode ultrasound usually contains scattering speckle noise which reduces the detailed resolution of the target and is regarded as an intrinsic noise that interferes with diagnostic precision. The aim of this study was to classify hepatic steatosis through applying attenuation correction with a phantom to reduce speckle noise in liver ultrasound tomography in patients. This retrospective study applied three randomized groups signifying different liver statuses.

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The roots of Achyranthes bidentata Blume (AB) is commonly used in the treatment of osteoporosis and dementia in traditional Chinese medicine. Pharmacological reports evidenced that AB possessed anti-osteoarthritis effects. However, there is little literature about the anti-dementia activities of AB.

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Background: The Cormack-Lehane (C-L) grade III airway is considered to be a challenging airway to intubate and is associated with a poor intubation success rate. The purpose of this study was to investigate whether the holding position, shapes, bend angles of the endotracheal tube (ET) and the stylet-assisted lifting of the epiglottis could improve the success rate of intubation.

Methods: Thirty-two participants, 26 physicians, 2 residents, and 4 nurse practitioners, with 12.

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