Publications by authors named "Lin Kun"
Background: This study aimed to evaluate the efficacy of third-generation sequencing (TGS) and a thalassemia (Thal) gene diagnostic kit in identifying Thal gene mutations.
Methods: Blood samples (n = 119) with positive hematology screening results were tested using polymerase chain reaction (PCR)-based methods and TGS on the PacBio-Sequel-II-platform, respectively.
Results: Out of the 119 cases, 106 cases showed fully consistent results between the two methods, with TGS identified HBA1/2 and HBB gene mutations in 82 individuals.
Peg-IFNα is one of the current therapeutic strategies for Hepatitis B virus (HBV) seroclearance. Nevertheless, the underlying mechanisms are not yet adequately understood. The objective of this study was to explore the potential mechanisms using multiomics approach.
View Article and Find Full Text PDFAxial Zero Thermal Expansion with Good Mechanical Strength in the Ni-Doped Kagome HoFe Magnets.
ACS Appl Mater Interfaces
December 2024
Article Synopsis
- Zero thermal expansion (ZTE) metals are highly desired for their ability to maintain dimensional stability, but their use is limited due to a small temperature range and brittleness.
- Researchers developed a new ZTE alloy (HoFeNi) by incorporating nickel, which broadens the operable temperature range while enhancing the ferromagnetic properties of the iron within it.
- The addition of excess iron improves the alloy's compressive strength and maintains ZTE characteristics, suggesting that this chemical design could lead to the creation of more effective ZTE alloys in the future.
Effect of Acetyl tributyl citrate on bone metabolism based on network toxicology and molecular docking technology.
Ecotoxicol Environ Saf
November 2024
This study aims to elucidate the intricate effects of Acetyl tributyl citrate (ATBC) on bone metabolism, disentangling the underlying molecular mechanisms that govern the impact of environmental contaminants on disease processes. Leveraging the exhaustive exploration of databases such as ChEMBL, STITCH, GeneCards, and OMIM, we have identified a comprehensive list of 164 potential targets intimately associated with both ATBC and bone metabolism. Following rigorous refinement using the STRING platform and Cytoscape software, we pinpointed ten core targets, encompassing KDM1A, EP300, HDAC2, EHMT2, DNMT1, and several others.
View Article and Find Full Text PDFFishery stock assessment is the basis of fishery management. This study explored the applicability of the Length-Based Spawning Potential Ratio method (LBSPR) to assess the exploitation status of data-limited fisheries. Using data from bottom trawl surveys in Zhanjiang Bay, the study estimated the relative fishing mortality (F/M) of Johnius belangerii stock.
View Article and Find Full Text PDFAssociation of oxidative balance score with hyperuricemia and gout: NHANES 2009-2018.
Front Endocrinol (Lausanne)
November 2024
Introduction: Oxidative stress plays a crucial role in the development and progression of hyperuricemia/gout. This study aims to explore the relationship between the Oxidative Balance Score (OBS) and hyperuricemia/gout.
Methods: The study utilized complete data from adult participants in the National Health and Nutrition Examination Survey (NHANES) spanning from 2009 to 2018.
Accelerating the alkaline hydrogen evolution reaction (HER), which involves the slow cleavage of HO-H bonds and the adsorption/desorption of hydrogen (H*) and hydroxyl (OH*) intermediates, requires developing catalysts with optimal binding strengths for these intermediates. Here, the unconventional hexagonal close-packed (HCP) high-entropy alloy (HEA) atomic layers are prepared composed of five platinum-group metals to enhance the alkaline HER synergistically. The breakthrough is made by layer-by-layer heteroepitaxial deposition of subnanometer RuRhPdPtIr HEA layers on the HCP Ru seeds, despite the thermodynamic stability of Rh, Pd, Pt, and Ir in a face-centered cubic (FCC) structure except for Ru.
View Article and Find Full Text PDFArticle Synopsis
- * A study collected samples from the Longitudinal Range-Gorge Region in China to evaluate Mo bioavailability, revealing that regions with high Mo concentration were mainly in the southern and northern mountains.
- * The research found that environmental factors, such as humidity and vegetation index, impacted Mo bioavailability mainly through their effects on organic matter and pH in the rhizosphere, highlighting these as key factors in Mo concentration.
Rationale: Cardiac-expressed long noncoding RNAs (lncRNAs) are important for cardiomyocyte (CM) differentiation and function. Several lncRNAs have been identified and characterized for early CM lineage commitment, however those in later CM lineage specification and maturation remain less well studied. Moreover, unique atrial / ventricular lncRNA expression has never been studied in detail.
View Article and Find Full Text PDFArticle Synopsis
- The high-entropy strategy is becoming popular in functional materials design due to its ability to create materials with unique properties by integrating diverse components.
- The study introduces "high-entropy magnets (HEMs)" that combine various magnetic compounds, like (Ti,Zr,Hf,Nb,Fe)Fe, resulting in complex magnetic behaviors influenced by temperature changes.
- Notably, the TiZrHfNbFe compound exhibits remarkable thermal expansion properties, achieving near-zero expansion across a wide temperature range due to the interactions of magnetic moments.
Article Synopsis
- The CREATE-X trial showed that adjuvant capecitabine can improve survival for high-risk triple-negative breast cancer patients, but the standard dose is often hard to tolerate for many in the US.
- A retrospective study at the University of Chicago Medicine evaluated the safety and tolerability of capecitabine in 67 TNBC patients, looking specifically at their relative dose intensity (RDI) and side effects over eight treatment cycles.
- Results indicated that the average RDI was significantly lower than in the CREATE-X trial, with hand-foot syndrome, diarrhea, and fatigue being the most common side effects; the study found no major differences in tolerability based on age, race, BMI, or initial dosage.
Article Synopsis
- - The study investigates the effectiveness and safety of compound porcine cerebroside and ganglioside injection (CPCGI) in improving cognitive and functional outcomes in patients with mild to moderate traumatic brain injury (TBI).
- - It is a multicenter, randomized, double-blind trial involving 900 adult patients, with 600 receiving CPCGI and 300 receiving piracetam as a control, followed by a 3-month evaluation period.
- - The primary goal is to assess changes in cognitive function using the Montreal Cognitive Assessment (MoCA) score, along with secondary measures like MMSE, GOS-E, and the Barthel Index.
Background: Gastric cancer (GC), especially the case with microsatellite stability (MSS) phenotype, has limited efficacy for immune checkpoint blockade (ICB) therapy. Metabolism reprogramming is newly recognized to affect tumor immune microenvironment (TIME). However, the relationship between metabolism reprogramming and immunotherapy for MSS GC has not been reported.
View Article and Find Full Text PDFExpansion of a Novel Subset of L-Selectin Classical Monocytes in Kawasaki Disease.
J Inflamm Res
September 2024
Article Synopsis
- - Kawasaki disease (KD) is an inflammatory condition in children linked to immune system issues, and a new monocyte subset called L-Selectin classical monocytes (SELL CM) was identified in KD patients through prior research.
- - A study analyzed blood samples from 81 KD patients and others to evaluate SELL CM and found its levels to be significantly elevated in KD kids compared to febrile and healthy children, with a noted decrease post-treatment with intravenous immunoglobulin (IVIG).
- - Results indicated that SELL CM could serve as a potential new diagnostic marker for KD due to its increased ratio during acute phases, suggesting it may help clinicians with KD diagnosis based on observable features.
Article Synopsis
- - The study investigated the genetic reasons for a fetal ultrasound showing a thickened nuchal translucency and a choroid plexus cyst.
- - Amniotic fluid and blood samples were analyzed, revealing normal chromosome karyotypes for the fetus and parents but a new 277 kb microdeletion at 14q11.2 in the fetus.
- - Following an induced abortion, the fetus was found to have macrocephaly, confirming the diagnosis of growth issues due to the microdeletion, which offers insights for future pregnancies.
Article Synopsis
- Maintaining balanced lipid levels is crucial for preventing lipotoxicity in tumors like colorectal cancer (CRC).
- The RNA-binding protein HuR appears to enhance the expression of the vitamin D receptor (VDR), which helps regulate triglyceride (TG) and total cholesterol (TC) levels in CRC.
- Targeting HuR could be a promising therapeutic strategy, as it affects VDR expression and lipid metabolism, ultimately influencing CRC growth.
Article Synopsis
- Early postoperative cerebral infarction (ePCI) is a critical complication affecting 11.1% of patients who experience spontaneous intracerebral hemorrhage (SICH) after surgery, mainly occurring in the middle cerebral artery territory.
- Identified predictors of ePCI include low Glasgow Coma Scale (GCS) scores, larger bleeding and hematoma volumes, and the presence of bilateral brain hernia.
- The study highlights that ePCI significantly increases the risk of mortality (hazard ratio of 3.6), emphasizing the need for further research on this complication in SICH patients.
Article Synopsis
- The study addresses the trade-off between activity and selectivity in acetylene semi-hydrogenation by developing a new Au@PdCu core-shell nanocatalyst that enhances both properties.
- The nanocatalyst achieved 100% acetylene conversion and 92.4% ethylene selectivity at 122 °C, with performance 3.3 times better than a traditional PdCu alloy.
- Advanced techniques like pair distribution function (PDF) and reverse Monte Carlo simulation (RMC) were used to analyze the atomic structure, revealing that low coordination and tensile strain in palladium sites are key for improving catalytic performance.
Background: Telomere shortening is strongly associated with cardiovascular aging and disease, and patients with shorter telomeres in peripheral blood leukocytes are at higher risk of cardiovascular diseases such as heart failure and atrial fibrillation (AF). Telomerase reverse transcriptase (TERT) maintains telomere length, and overexpression of TERT has been shown to reduce cardiomyocyte apoptosis and myocardial infarct size, and extend the lifespan of aged mice. However, the specific impact of TERT on the electrophysiology of cardiomyocytes remains to be elucidated.
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- Interfacial strain engineering can transform materials and create new properties, but its effectiveness is limited to a small spatial area, particularly in 2D thin films where the critical thickness for maintaining strain is under 20 nm.
- Creating a 3D interface can address these limitations by allowing strain effects to extend deeper into thicker materials like BaZrO thin films.
- The unique out-of-phase boundary (OPB) structure formed in BaZrO due to lattice mismatch enhances strain distribution and maintains ferroelectric properties, with a notable ferroelectricity measurement of 13 μC/cm along the thickness.
Article Synopsis
- Exchange bias (EB) is an important magnetic property that arises from complex interactions after being cooled in a magnetic field, with the intrinsic zero-field-cooled (ZEB) variant found in only a few materials.
- Researchers have discovered a significant ZEB field of 4.95 kOe in a specific group of kagome metals by optimizing ferrimagnetism, which is nearly double that of previously known materials.
- The team showed that the giant ZEB effect comes from strong antiferromagnetic interactions within a matrix enriched by manganese, leading to a unique magnetic structure that contributes to high coercivity in these materials.
Article Synopsis
- Scientists made a special film using gallic acid, chitosan, and cellulose to protect food from bad bacteria and keep it fresh.
- The film is really strong, can block harmful UV light, and helps stop water from getting through it.
- When used for packaging oysters, this film kept them fresh longer and improved their safety by fighting off germs.
Article Synopsis
- - Glioma is a common and aggressive brain tumor linked to poor patient outcomes, and this study investigates the role of the CNOT7 protein, which has not been previously reported in this context.
- - Using data from various cancer databases and a series of cellular function experiments, the researchers found that high levels of CNOT7 correlated with worse prognosis and that reducing CNOT7 expression led to decreased glioma cell growth and spread.
- - The study reveals that CNOT7 influences glioma development through specific molecular pathways and is regulated by the HDAC2 protein, suggesting it may serve as a potential therapeutic target or biomarker for glioma.
Article Synopsis
- - The study aimed to analyze the characteristics of HPV and cervical diseases in women aged 35-64, using data from over 149,000 cervical cell samples screened between 2018 and 2023.
- - Results showed that 86.60% of the women had normal cervical cytology, with some diagnosed with various degrees of cervical lesions; HPV prevalence was found to be 8.60%, with specific HPV types being more common in invasive cervical cancer cases.
- - The study highlighted that older age correlates with higher HPV prevalence, particularly noting that those above 55 years had more multiple HPV infections, and it emphasized the need for increased awareness and action against HPV33 infections.