DRTN: Dual Relation Transformer Network with feature erasure and contrastive learning for multi-label image classification.

The objective of multi-label image classification (MLIC) task is to simultaneously identify multiple objects present in an image. Several researchers directly flatten 2D feature maps into 1D grid feature sequences, and utilize Transformer encoder to capture the correlations of grid features to learn object relationships. Although obtaining promising results, these Transformer-based methods lose spatial information.

HSPA8 dampens SCAP/INSIG split and SREBP activation by reducing PKR-mediated INSIG phosphorylation.

Lipid accumulation in renal tubules is a major determinant of diabetic kidney disease (DKD), and activation of SREBPs plays a central role in this process. Our study aims to explore whether HSPA8, a molecular chaperone, is the master regulator of INSIG/SREBPs function in DKD. Here, we show that tubular epithelial cell (TEC)-specific knockout of HSPA8 upregulates the phosphorylation of INSIG1 and INSIG2, which disrupts the interaction between INSIG proteins and SCAP, leading to SREBP activation.

A rapid and effective approach to building a life-saving multidisciplinary team for transferred postpartum haemorrhage patients: leveraging trauma experience-a retrospective study.

Background: Establishing an efficient multidisciplinary team for transferred postpartum haemorrhage (PPH) cases is challenging due to limited clinical exposure. We hypothesised that leveraging trauma team experience could effectively facilitate the development of such a team within a short timeframe.

Methods: In September 2019, a multidisciplinary team was established at our tertiary care centre to provide rapid management of critical PPH cases transferred from the obstetric clinic, prioritising immediate resuscitation and haemostatic interventions.

Breast cancer image classification based on H&E staining using a causal attention graph neural network model.

Breast cancer image classification remains a challenging task due to the high-resolution nature of pathological images and their complex feature distributions. Graph neural networks (GNNs) offer promising capabilities to capture local structural information but often suffer from limited generalization and reliance on shortcut features. This study proposes a novel causal discovery attention-based graph neural network (CDA-GNN) model.

Multi-step functionalization of hydrogels through mechano- and photo-responsive linkages.

Patterning soft materials with cell adhesion motifs can be used to emulate the structures found in natural tissues. While patterning in tissue is driven by cellular assembly, patterning soft materials in the laboratory most often involves light-mediated chemical reactions to spatially control the presentation of cell binding sites. Here we present hydrogels that are formed with two responsive crosslinkers-an anthracene-maleimide adduct and a disulfide linkage-thereby allowing simultaneous or sequential patterning using force and UV light.

Deubiquitinating enzyme USP2 alleviates muscle atrophy by stabilizing PPARγ.

Insulin resistance, a hallmark of type 2 diabetes, accelerates muscle breakdown and impairs energy metabolism. However, the role of Ubiquitin Specific Peptidase 2 (USP2), a key regulator of insulin resistance, in sarcopenia remains unclear. Peroxisome proliferator activated receptor γ (PPARγ) plays a critical role in regulating muscle atrophy.

Analysis of the accuracy of disease prediction in pediatric ward patients based on the modified early warning score for children: A randomized controlled trial.

Background: Due to their young age and limited ability to communicate, pediatric patients in internal medicine wards are at risk of nursing assessment errors, which can lead to adverse events and disputes.

Objective: To explore the application effect of modified pediatric early warning score (PEWS) in the early identification of critically ill children in pediatric general wards.

Design: A single-blind, two-arm randomized controlled trial was conducted using a convenience sampling method.

A 4-Week Mobile App-Based Telerehabilitation Program vs Conventional In-Person Rehabilitation in Older Adults With Sarcopenia: Randomized Controlled Trial.

Background: Sarcopenia is closely associated with a poor quality of life and mortality, and its prevention and treatment represent a critical area of research. Resistance training is an effective treatment for older adults with sarcopenia. However, they often face challenges when receiving traditional rehabilitation treatments at hospitals.

Innovative Ricin Toxin Detection: Unraveling Apurinic/Apyrimidinic Lyase Activity and Developing Fluorescence Sensors.

Ricin toxin (RT) is a potential bioterrorism agent because of its high potency, extremely small lethal dose, ease of preparation, and notable stability. Therefore, a portable method is urgently required to efficiently detect and determine the presence of toxicity of RT and evaluate its potency for public health monitoring and counter-bioterrorism responses. Currently, enzyme-based assays for detecting RT mainly focus on its -glycosidase activity.

Association studies of vasoactive genes and preeclampsia in taiwan.

Background: Preeclampsia (PE) is a serious condition characterized by hypertension and proteinuria after 20 weeks of gestation. The exact cause of PE is unknown but may involve abnormalities in the renin-angiotensin-aldosterone system (RAAS) and endothelial nitric oxide synthase (eNOS). Genetic variations in angiotensinogen (AGT), angiotensin-converting enzyme (ACE), and eNOS genes have been associated with PE.

Sub-millikelvin-resolved superconducting nanowire single-photon detector operates with sub-pW infrared radiation power.

The noise equivalent temperature difference (NETD) indicates the minimum temperature difference resolvable by using an infrared detector. The lower the NETD, the better the sensor can register small temperature differences. In this work, we proposed a strategy to achieve a high temperature resolution using a superconducting nanowire single-photon detector (SNSPD) with ultra-high sensitivity.

Blockade of neutral sphingomyelinase 2 exerts antitumor effect on metastatic castration resistant prostate cancer cells and promotes tumor regression when combined with Enzalutamide.

Prostate cancer (PCa) is the second leading cause of cancer-related deaths among American men. The development of metastatic castration resistant PCa (mCRPC) is the current clinical challenge. Antiandrogens such as Enzalutamide (ENZ) are commonly used for CRPC treatment.

Construction of a Novel Necroptosis-Related Signature in Rat DRG for Neuropathic Pain.

Background: Recent studies have shown necroptosis may play a role in the development of inflammation-associated pain. However, research on the correlation between necroptosis-related genes and neuropathic pain in the dorsal root ganglia (DRG) is limited. This study aims to identify a gene signature related to necroptosis in DRG that can predict neuropathic pain.

Determining the effective dose of esketamine combined with propofol for painless hysteroscopy: a prospective dose-finding study.

Background: The combination of esketamine and propofol has become a common choice for total intravenous anesthesia in hysteroscopic procedures. However, the optimal effective dose has not yet been determined. The aim of this study was to determine the median effective dose (ED) and 95% effective dose (ED) of esketamine compounded with propofol for painless hysteroscopy.

Delving into female breast cancer: Distinct disease-specific survival outcomes between invasive lobular and ductal carcinomas revealed by propensity score matching.

Purpose: The difference in prognosis between invasive lobular carcinoma (ILC) and invasive ductal carcinoma (IDC) is still controversial in the academic community. Resolving this controversy can help to more accurately determine patients' prognosis, provide further personalized treatment, alleviate unnecessary psychological burden for some patients, and provide direction for further fundamental research.

Patients And Methods: A retrospective cohort study was conducted using the SEER Research Plus Data 8 Registries, Nov 2021 sub (1978-2019), including female breast cancer patients diagnosed with ILC or IDC between 2010 and 2015.

The Influence of Matrix Resin Toughening on the Compressive Properties of Carbon Fiber Composites.

The study investigated the effects of a toughening agent and micron-sized toughening particles (TP) on the resin and carbon fiber-reinforced polymer (CFRP) composites, with a particular focus on compressive strength. The results showed that the addition of the toughening agent improved the overall mechanical properties of both the resin and CFRP but had a minor effect on the residual compressive strength (CAI) of CFRP after impact. Compared to the pure toughening agent, the addition of TP increased the CAI, GIC, and GIIC of CFRP by 74%, 35%, and 68%, respectively.

Study on the structural stability of partial cable-stayed bridges with multiple towers and high piers during construction.

To clarify the structural safety and stability of partial cable-stayed bridges with multiple towers and high piers during the construction stage, a finite element analysis model of the entire construction process was established using a five-tower, six-span, partial cable-stayed bridge in Shaanxi Province, China, as the engineering background. Linear elasticity and nonlinear stability analyses were carried out in the following key construction stages: bare tower construction, maximum cantilever construction without cables, maximum cantilever construction with cables, side-span closure, secondary mid-span closure, mid-span closure, and second-phase paving. A sensitivity analysis of the structural parameters (the main tower stiffness, main pier stiffness, and main beam stiffness) was conducted.

Quercetin Alleviates Diabetic Peripheral Neuropathy by Regulating Axon Guidance Factors and Inhibiting the Rho/ROCK Pathway in vivo and in vitro.

Purpose: The axon guidance factors and Rho/ROCK pathway play crucial roles in axon protection and nerve repair and has been implicated in the development of diabetic peripheral neuropathy (DPN). This study investigates the protective effects of quercetin against DPN, focusing on axon guidance factors and Rho/ROCK pathway.

Methods: DPN was induced by intraperitoneal injection of streptozotocin (STZ) to Sprague-Dawley rats.

ALKBH5 activates CEP55 transcription through m6A demethylation in FOXP2 mRNA and expedites cell cycle entry and EMT in ovarian cancer.

Background: Centrosomal protein of 55 kDa (CEP55) overexpression has been linked to tumor stage, aggressiveness of the tumor, poor prognosis, and metastasis. This study aims to elucidate the action of CEP55 in ovarian cancer (OC) and the regulation by the alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 (ALKBH5)/Forkhead box protein P2 (FOXP2) axis.

Methods: Differentially expressed genes in OC were identified using in silico identification, followed by prognostic value assessment.

Nuclear translocation of SIRT4 mediates deacetylation of U2AF2 to modulate renal fibrosis through alternative splicing-mediated upregulation of CCN2.

TGF-β stimulates CCN2 expression which in turn amplifies TGF-β signaling. This process promotes extracellular matrix production and accelerates the pathological progression of fibrotic diseases. Alternative splicing plays an important role in multiple disease development, while U2 small nuclear RNA auxiliary factor 2 (U2AF2) is an essential factor in the early steps of pre-mRNA splicing.

A Review of Advances in Mitochondrial Research in Cancer.

Background: Abnormalities in mitochondrial structure or function are closely related to the development of malignant tumors. Mitochondrial metabolic reprogramming provides precursor substances and energy for the vital activities of tumor cells, so that cancer cells can rapidly adapt to the unfavorable environment of hypoxia and nutrient deficiency. Mitochondria can enable tumor cells to gain the ability to proliferate, escape immune responses, and develop drug resistance by altering constitutive junctions, oxidative phosphorylation, oxidative stress, and mitochondrial subcellular relocalization.

Obesity's Unexpected Influence: Reduced Alphavirus Transmission and Altered Immune Activation in the Vector.

Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are emerging/re-emerging alphaviruses transmitted by Aedes spp. mosquitoes and responsible for recent disease outbreaks in the Americas. The capacity of these viruses to cause epidemics is frequently associated with increased mosquito transmission, which in turn is governed by virus-host-vector interactions.

Humoral and T-cell-mediated responses to an insect-specific flavivirus-based Zika virus vaccine candidate.

Flaviviruses represent a significant global health threat and relatively few licensed vaccines exist to protect against them. Insect-specific flaviviruses (ISFVs) are incapable of replication in humans and have emerged as a novel and promising tool for flavivirus vaccine development. ISFV-based flavivirus vaccines have shown exceptional safety, immunogenicity, and efficacy, however, a detailed assessment of the correlates of protection and immune responses induced by these vaccines are still needed for vaccine optimization.