Parameters Indicating Development of Influenza-Associated Acute Necrotizing Encephalopathy: Experiences from a Single Center.

BACKGROUND Influenza-associated acute necrotizing encephalopathy (IANE) can be lethal and disabling and have a sudden onset and deteriorate rapidly but lacks early diagnostic indicators. We aimed to examine the early clinical diagnostic indicators in children with IANE. MATERIAL AND METHODS Acute influenza patients were grouped according to their clinical manifestations: flu alone (FA), flu with febrile seizure (FS), influenza-associated encephalopathy (IAE), and IANE.

A novel AIE molecule as a hole transport layer enables efficient and stable perovskite solar cells.

A low-cost and efficient hole transport layer (HTL) material (TPE-CZ) with the aggregation-induced emission (AIE) effect has been synthesized. Due to the AIE effect, perovskite solar cells with TPE-CZ as the HTL deliver a higher power conversion efficiency (PCE) of 18% with better stability than those with the reference HTL (Spiro-OMeTAD).

Clinical application and accuracy analysis of 3D printing guide plate based on polylactic acid in mandible reconstruction with fibula flap.

Background: Due to the special anatomy morphology and physiological function of the mandible, it has always become a challenge to accurately reconstruct the mandibular defect in maxillofacial surgery. Digital three dimensions (3D) printing surgical guide, as the effective method for individual and accurate surgery, is a hotspot of clinical research at present. In this study, 3D printing PLA surgical guide plate was applied to reconstruct the mandibular defect with fibula flap, its clinical effect and accuracy were evaluated, which aimed to improve the accurate reconstruction of mandibular defects.

Out-of-Plane Alignment of Conjugated Semiconducting Polymers by Horizontal Rotation in a High Magnetic Field.

The effective control of film morphology and molecular packing in the out-of-plane direction of semiconductor polymers plays a critical role in governing charge carrier transport in the direction perpendicular to the substrate. In this study, a highly out-of-plane alignment of the n-type polymer P(NDI2OD-T2) film has been successfully achieved by horizontal rotation in a high magnetic field (HR-HMF). The out-of-plane alignment of the P(NDI2OD-T2) film has showed a change from 72% face-on to 98.

N and O multi-coordinated vanadium single atom with enhanced oxygen reduction activity.

Recently, atomically dispersed transition-metal single atom in nitrogen-doped carbon matrix as electrocatalysts has aroused general interest. However, there is no report about vanadium single atom for ORR in the literature. According to d-band center theory for transition-metals, the performance of catalysts is regulated by the electronic structure of the catalytic center which determines the intermediate adsorption kinetics.

Hierarchical iron molybdate nanostructure array for efficient water oxidation through optimizing electron density.

The water oxidation reaction plays a major role in many alternative-energy systems because it provides the electrons and protons required for the use of renewable electricity. We report the tuning of the iron molybdate (FeMoO) electron structure via a coupled interface between the catalytic centers and the substrate. Our developed FeMoO catalysts can provide a 50 mA cm current density at 1.

Massive Open Online Courses-based blended versus face-to-face classroom teaching methods for fundamental nursing course.

An increasing number of studies focus on the effectiveness of Massive Open Online Courses (MOOC)-based blended learning, whereas none have yet studied using it for teaching fundamental nursing skills at an undergraduate level.To evaluate the effectiveness of MOOC-based blended learning versus face-to-face classroom teaching techniques within the fundamental nursing course at the Faculty of Nursing, University of Xiang Nan, China.This cluster randomized controlled trial enrolled 181 students and assigned them into either an MOOC-based blended or a face-to-face classroom teaching group, both involving the Fundamental Nursing course for undergraduate nursing students.

Mutation analysis and prenatal diagnosis of a family with congenital contractural arachnodactyly.

Background: Congenital contractural arachnodactyly (CCA) is a rare autosomal dominant condition caused by mutations in the fibrillin 2 gene (FBN2). The primary clinical symptoms of CCA include multiple flexion contractures, arachnodactyly, dolichostenomelia, scoliosis, abnormal pinnae, muscular hypoplasia, and crumpled ears.

Methods: We used whole-exome sequencing technology to examine an arthrogryposis multiplex congenita and used Sanger sequencing technology to genetically confirm its family.

Surface doping of non-fullerene photoactive layer by soluble polyoxometalate for printable organic solar cells.

The non-fullerene photoactive layer (PTB7-Th:IEICO-4F) film is first immersed into a PMA solution to induce an effective surface p-type doping. An improved hole-collection and a high PCE of 11.37% was obtained, although the non-fullerene OSCs were without a commonly evaporated MoO3.

Sc(OTf)-Catalyzed C-C Bond-Forming Reaction of Cyclic Peroxy Ketals for the Synthesis of Highly Functionalized 1,2-Dioxene Endoperoxides.

A new and general Sc(OTf)-catalyzed C-C bond-forming reaction of 3-(2-methoxyethoxy)-endoperoxy ketals with silyl ketene acetals, silyl enol ethers, allyltrimethylsilane, and trimethylsilyl cyanide has been developed via the reactive peroxycarbenium ions, affording a wide range of complicated 3,3,6,6-tetrasubstituted 1,2-dioxenes bearing adjacent quaternary carbons and 3-acetyl/allyl/cyano functional groups in good yields at room temperature. Notably, the resultant 1,2-dioxenes are structurally stable, which can be facially transformed into another important 1,2-dioxane endoperoxide under conventional hydrogenation conditions without deconstructing the weak O-O bond.

Spatial transmission network construction of influenza-like illness using dynamic Bayesian network and vector-autoregressive moving average model.

Background: Although vaccination is one of the main countermeasures against influenza epidemic, it is highly essential to make informed prevention decisions to guarantee that limited vaccination resources are allocated to the places where they are most needed. Hence, one of the fundamental steps for decision making in influenza prevention is to characterize its spatio-temporal trend, especially on the key problem about how influenza transmits among adjacent places and how much impact the influenza of one place could have on its neighbors. To solve this problem while avoiding too much additional time-consuming work on data collection, this study proposed a new concept of spatio-temporal route as well as its estimation methods to construct the influenza transmission network.

Magnetic field effect on the photocatalytic degradation of methyl orange by commercial TiO powder.

In this work, by taking commercial P25 hydrophilic titanium dioxide (TiO) as a photocatalyst, the magnetic field effect (MFE) on the photodegradation rate of methyl orange is studied. It is found that a relatively lower magnetic field = 0.28 T can efficiently enhance the photodegradation efficiency of commercial TiO by 24%.

Depletion of Survivin suppresses docetaxel-induced apoptosis in HeLa cells by facilitating mitotic slippage.

The anticancer effects of taxanes are attributed to the induction of mitotic arrest through activation of the spindle assembly checkpoint. Cell death following extended mitotic arrest is mediated by the intrinsic apoptosis pathway. Accordingly, factors that influence the robustness of mitotic arrest or disrupt the apoptotic machinery confer drug resistance.

Enhancing carbon dioxide gas-diffusion electrolysis by creating a hydrophobic catalyst microenvironment.

Electroreduction of carbon dioxide (CO) over copper-based catalysts provides an attractive approach for sustainable fuel production. While efforts are focused on developing catalytic materials, it is also critical to understand and control the microenvironment around catalytic sites, which can mediate the transport of reaction species and influence reaction pathways. Here, we show that a hydrophobic microenvironment can significantly enhance CO gas-diffusion electrolysis.

Characterization of the complete chloroplast genome of (Liliaceae).

is a perennial ornamental plant in the family Liliaceae, it is also a valuable medicinal plant. To enrich the genetic resources of , its chloroplast genome was determined by Illumina sequencing data. The chloroplast genome is a typical quadripartite structure with a size of 153,983 bp, of which the LSC region is 83,471 bp, the SSC region is 18,010 bp, and the pair of IR regions is 26,251 bp.

Identification of atypical mitogen-activated protein kinase MAPK4 as a novel regulator in acute lung injury.

Background: Acute lung injury (ALI) is a serious disease with highly morbidity and mortality that causes serious health problems worldwide. Atypical mitogen activated protein kinases (MAPKs) play critical roles in the development of tissues and have been proposed as promising therapeutic targets for various diseases. However, the potential role of atypical MAPKs in ALI remains elusive.

tRNA methyltransferase 10 homologue A () mutation in a Chinese patient with diabetes, insulin resistance, intellectual deficiency and microcephaly.

Introduction: Loss-of-function mutations in tRNA methyltransferase 10 homologue A (), a tRNA methyltransferase, have recently been described as a monogenic cause of early-onset diabetes with microcephaly, epilepsy and intellectual disability.

Research Design And Methods: We report a Chinese young patient who was diagnosed with diabetes mellitus as a result of a mutation.

Results: A homozygous mutation c.

Formal [5+1] annulation reactions of dielectrophilic peroxides: facile access to functionalized dihydropyrans.

A general [5+1] annulation reaction, which utilized 4-bromo- or 4-mesyloxy-but-2-enyl peroxides as unique five-atom bielectrophilic synthons to participate in the C-C and the subsequent umpolung C-O bond-forming reactions with C1 nucleophiles, has been developed for the facile synthesis of 2,2-disubstituted dihydropyrans in high yields under mild basic conditions. The dihydropyrans, which are readily prepared on a gram scale by this new method, can be flexibly transformed into the biologically important tetrahydropyrans and pyranones in 1-2 steps.

Abdominal Adiposity and Total Body Fat as Predictors of Cardiometabolic Health in Children and Adolescents With Obesity.

We aimed to assess the role of adipose tissue distribution in cardiometabolic risk (in particular insulin sensitivity) in a population of children and adolescents with obesity. In this cross-sectional study, participants were 479 children and adolescents with obesity (322 boys and 157 girls) aged 3 to 18 years attending the Children's Hospital at Zhejiang University School of Medicine (Hangzhou, China). Clinical assessments included anthropometry, body composition (DXA scans), carotid artery ultrasounds, and OGTT.

LOXL1 modulates the malignant progression of colorectal cancer by inhibiting the transcriptional activity of YAP.

Background: LOX-like 1 (LOXL1) is a lysyl oxidase, and emerging evidence has revealed its effect on malignant cancer progression. However, its role in colorectal cancer (CRC) and the underlying molecular mechanisms have not yet been elucidated.

Methods: LOXL1 expression in colorectal cancer was detected by immunohistochemistry, western blotting and real-time PCR.

Robust metal ion-chelated polymer interfacial layer for ultraflexible non-fullerene organic solar cells.

Achieving high power conversion efficiency and good mechanical robustness is still challenging for the ultraflexible organic solar cells. Interlayers simultaneously having good mechanical robustness and good chemical compatibility with the active layer are highly desirable. In this work, we present an interlayer of Zn-chelated polyethylenimine (denoted as PEI-Zn), which can endure a maximum bending strain over twice as high as that of ZnO and is chemically compatible with the recently emerging efficient nonfullerene active layers.

Diagnostic performance of diffusion-weighted imaging combined with dynamic contrast-enhanced magnetic resonance imaging for prostate cancer: a systematic review and meta-analysis.

Background: The diagnostic performance of diffusion-weighted imaging (DWI) combined with dynamic contrast-enhanced (DCE)-magnetic resonance imaging (MRI) for the detection of prostate cancer (PCa) has not been studied systematically to date.

Purpose: To investigate the value of DWI combined with DCE-MRI quantitative analysis in the diagnosis of PCa.

Material And Methods: A systematic search was conducted through PubMed, MEDLINE, the Cochrane Library, and EMBASE databases without any restriction to language up to 10 December 2019.

sp. nov., isolated from the gut of plastic-eating larvae of the coleopteran insect .

A bacterial strain, BIT-d1, was isolated from the gut of plastic-eating larvae of the coleopteran insect . Its taxonomic position was analysed using a polyphasic approach. Cells were white-pigmented, Gram-stain-negative, non-motile, long rods without flagella.

Reversible Switching of Charge Transfer at the Graphene-Mica Interface with Intercalating Molecules.

Understanding and controlling charge transfer through molecular nanostructures at interfaces is of paramount importance, particularly for electronic devices but also for contact electrification or in bioelectronics. We investigate the influence of intercalation and exchange of molecularly thin layers of small molecules (water, ethanol, 2-propanol, and acetone) on charge transfer at the well-defined interface between an insulator (muscovite mica) and a conductor (graphene). Raman spectroscopy is used to probe the charge carriers in graphene.