Mechanical and Failure Behavior of Soft-Hard Composite Rock with Three Parallel Joints Under Uniaxial Loading: Insights Based on AE and DIC Techniques.

Jointed soft-hard composite rocks are frequently encountered in nature, and this complex structure contributes to unpredictable fracturing mechanisms and failure behavior. In this study, soft-hard composite rocks with three joints were fabricated to conduct a uniaxial loading experiment, supplemented by Digital Image Correlation (DIC) and Acoustic Emission (AE) experiments. The results indicate that the mechanical parameters display a V-shape variation trend with the increase of joint angle, which minimized at 30°.

Insights into effects of processing and food matrices on structure and ELISA detection of sarcoplasmic calcium binding protein.

The sandwich ELISA (sELISA) targeting sarcoplasmic calcium binding protein (SCP) is significantly influenced by food matrices, yet the mechanisms are unclear. To clarify the comprehensive effects of environments, matrices, and processing, SCP treated with diverse temperatures, pH, and matrices was subjected to ELISA, electrophoresis, multispectroscopic and molecular simulation assays. Recoveries of sELISA and indirect competitive ELISA (icELISA) were inhibited above 80 °C and 100 °C due to the unfolding of SCP.

Energy-migration mediated ratiometric upconversion luminescence nanothermometer: Erbium sublattice vs. ytterbium sublattice.

Accurate lanthanides featured with the abundant ladder-like excited states may enable one single activator to exhibit a multitude of emission bands. The elaborate manipulation on such emission bands can realize the modulation of emission color and therefore lead to plenty of applications. The modification of up-conversion dynamics via energy migration within nanostructure can lead to temperature-dependent colormetric lanthanide up-conversion emissions and has been proposed to design high-performance luminescence nanothermometers.

Filter Pruning by High-Order Spectral Clustering.

Large amount of redundancy is widely present in convolutional neural networks (CNNs). Identifying the redundancy in the network and removing the redundant filters is an effective way to compress the CNN model size with a minimal reduction in performance. However, most of the existing redundancy-based pruning methods only consider the distance information between two filters, which can only model simple correlations between filters.

Macrophage phenotypes modulate neoangiogenesis and fibroblast profiles in synovial-like organoid cultures.

Objective: To investigate the interaction among the cells thought to be foundational to inflammation, fibrosis, and angiogenesis in the synovial membrane.

Method: We encapsulated fibroblasts, polarized macrophages, and endothelial cells in a 3D culture system. We used this model to determine the cellular transcriptional profiles, cytokine secretion, and vascular formation associated with different macrophage phenotype conditions.

Effect of different cement distribution on the clinical efficacy of vertebral compression fractures in unilateral percutaneous vertebroplasty.

Background: Osteoporotic fractures and their complications are increasingly harmful to the elderly. The purpose of this study was to evaluate the clinical effect of postoperative cement distribution for Osteoporotic vertebral compression fracture in patients undergoing unilateral percutaneous vertebroplasty.

Purpose: To explore the effect of cement distribution on the efficacy of unilateral percutaneous vertebroplasty to provide effective preventive and therapeutic measures to prevent postoperative vertebral fracture and improve the surgical efficacy.

Characterization of Bozitinib as a potential therapeutic agent for MET-amplified gastric cancer.

Hyperactive c-Met signaling pathway caused by altered MET is a common mechanism underlying gastric cancer and represents an attractive target for the treatment of gastric cancer with MET alterations. However, no c-Met kinase inhibitors are currently approved specifically for the treatment of c-Met-amplified gastric cancer. Recently, bozitinib, a highly selective c-Met kinase inhibitor, has shown remarkable potency in selectively inhibiting MET-altered non-small cell lung cancer and secondary glioblastoma.

Efficient synthesis of fluorinated triphenylenes with enhanced arene-perfluoroarene interactions in columnar mesophases.

The high potential of non-covalent arene-fluoroarene intermolecular interactions in the design of liquid crystals lies in their ability to strongly promote self-assembly, improve the order and stability of the supramolecular mesophases, and enable tuneability of the optical and electronic properties, which can potentially be exploited for advanced applications in display technologies, photonic devices, sensors, and organic electronics. We recently successfully reported the straightforward synthesis of several mesogens containing four lateral aliphatic chains and derived from the classical triphenylene core self-assembling in columnar mesophases based on this paradigm. These mesogenic compounds were simply obtained in good yields by the nucleophilic substitution (SFAr) of various types of commercially available fluoroarenes with the electrophilic organolithium derivatives 2,2'-dilithio-4,4',5,5'-tetraalkoxy-1,1'-biphenyl (2Li- ).

Personalized bone organoid using iPSC-derived cells for clinically relevant applications.

Patient-specific induced pluripotent stem cells (iPSCs)-based modeling potentially recapitulates the pathology and mechanisms more faithfully than cell line models and general animal models. Utilizing iPSC-derived cells for personalized bone formation research offers a powerful tool to better understand the role of individual differences in bone health and disease and provide more precise information for personalized bone regeneration therapies. Here we generated iPSC-derived mesenchymal progenitor cells (iMPCs), endothelial cells (iECs), and macrophages (iMØ), from different donors.

Pyrazine derivative synthesis in a continuous-flow system: a green synthesis of pyrazinamide from pyrazine esters and amines catalyzed by Lipozyme® TL IM from .

Pyrazinamide derivatives have been extensively studied for their biological activities, such as anti-tuberculosis activity and antiviral activities. In this work, a continuous-flow system was developed for the synthesis of pyrazinamide derivatives from pyrazine esters and amines (aliphatic amine, benzylamines and morpholine) catalyzed by Lipozyme® TL IM from , which was used for the first time. The reaction parameters including solvent, substrate ratio, reaction temperature and reaction time/flow rate were also studied in detail.

Cyclopiazonic acid suppresses the function of Leydig cells in prepubertal male rats by disrupting mitofusin 1-mediated mitochondrial function.

This research investigated the impact of cyclopiazonic acid (CPA), a mycotoxin, on the function of progenitor Leydig cells (PLCs) in prepubertal male rats, focusing on its potential disruption of mitochondrial integrity through mitofusin 1 (MFN1) modulation. In vivo, Sprague Dawley rats received CPA (0.2, 1, 5 mg/kg/day) via gavage from postnatal days 21-28 to evaluate PLC function and mitochondrial morphology using serum hormone levels, histology, qPCR, and Western blot analyses.

Metformin Modulates Cell Oxidative Stress to Mitigate Corticosteroid-Induced Suppression of Osteogenesis in a 3D Model.

Background: Corticosteroids provide well-established therapeutic benefits; however, they are also accompanied by adverse effects on bone. Metformin is a widely used medication for managing type 2 diabetes mellitus. Recent studies have highlighted additional therapeutic benefits of metformin, particularly concerning bone health and oxidative stress.

Two-step tandem synthesis of sugar-containing pyrimidine derivatives catalyzed by Lipozyme® TL IM in continuous-flow microreactors.

A novel series of sugar-containing pyrimidine derivatives have been synthesized an effective and convenient two-step tandem synthesis in continuous-flow microreactors with excellent regioselectivity. Using continuous-flow microreactors to assemble two-step reactions into one unit can effectively avoid separating and purifying intermediates. Moreover, this method allows the optimization of reaction parameters for each unit individually.

Effectiveness of ePRO-based symptom management for cancer patients: a systematic review and meta-analysis of randomized controlled studies.

Purpose: To systematically synthesize the evidence on the effectiveness of electronic patient-reported outcome (ePRO)-based symptom management on readmission rate, quality of life, symptom burden, anxiety, depression, and mortality in adult cancer patients.

Method: A systematic review and meta-analysis were conducted according to the PRISMA guideline in PubMed, Web of Science, EMBASE, the Cochrane Library, CINAHL, and Scopus for studies of randomized controlled trials reporting ePRO-based symptom management from January 1st, 2018, to May 31st, 2023. Two reviewers independently assessed risk-of-bias using Cochrane Risk-of-Bias version 2 and extracted the data.

Hydrogel-Enhanced Autologous Chondrocyte Implantation for Cartilage Regeneration-An Update on Preclinical Studies.

Autologous chondrocyte implantation (ACI) and matrix-induced ACI (MACI) have demonstrated improved clinical outcomes and reduced revision rates for treating osteochondral and chondral defects. However, their ability to achieve lasting, fully functional repair remains limited. To overcome these challenges, scaffold-enhanced ACI, particularly utilizing hydrogel-based biomaterials, has emerged as an innovative strategy.

Risk factors for deep vein thrombosis of the lower extremity after total hip arthroplasty.

Objective: To investigate the risk factors for deep vein thrombosis (DVT) following total hip arthroplasty (THA).

Methods: Patients who underwent THA in the Department of Joint Surgery at the Sixth Affiliated Hospital of Xinjiang Medical University from September 2020 to December 2022 were retrospectively selected based on inclusion criteria. They were divided into the DVT group (n = 65) and the non-DVT group (n = 397) according to the occurrence of postoperative DVT.

In vitro human cell-based models: What can they do and what are their limitations?

It is said that all models are wrong, but some are useful. In vitro human cell-based models are a prime example of this maxim. We asked researchers: when is your model system useful? How can it be made more useful? What are its limitations?

Fibroblast growth receptor 1 is regulated by G-quadruplex in metastatic breast cancer.

Limiting cellular plasticity is of key importance for the therapeutic targeting of metastatic breast cancer (MBC). Fibroblast growth receptor (FGFR) is a critical molecule in cellular plasticity and potent inhibitors of FGFR enzymatic activity have been developed, but kinase independent functions for this receptor also contribute to MBC progression. Herein, we evaluated several FGFR inhibitors and find that while FGFR-targeted kinase inhibitors are effective at blocking ligand-induced cell growth, dormant cells persist eventually giving rise to MBC progression.

A prediction model based on high serum SH2B1 in patients with non-small cell lung cancer.

Background: Identifying a specific biomarker will facilitate the diagnosis and prediction of non-small cell lung cancer (NSCLC). The aim of this study was to investigate the serum SH2B1 in patients with NSCLC and healthy volunteers and establish a novel prediction model.

Methods: A total 103 NSCLC patients and 108 healthy volunteers were selected from December 2019 to December 2020.

Failure Mechanism and Control Mechanism of Intermittent Jointed Rock Bridge Based on Acoustic Emission (AE) and Digital Image Correlation (DIC).

Deep foundation pit excavation is an important way to develop underground space in congested urban areas. Rock bridges prevent the interconnection of joints and control the deformation and failure of the rock mass caused by excavation for foundation pits. However, few studies have considered the acoustic properties and strain field evolution of rock bridges.