Background: Predicting mortality in sepsis-related acute kidney injury facilitates early data-driven treatment decisions. Machine learning is predicting mortality in S-AKI in a growing number of studies. Therefore, we conducted this systematic review and meta-analysis to investigate the predictive value of machine learning for mortality in patients with septic acute kidney injury.
View Article and Find Full Text PDFBackground: To explore the correlation between the levels of D-dimer (D-D), fibrinogen (FIB), fibrinogen degradation products (FDP) and platelets (PLT) in peripheral blood of patients with lower limb fractures and the formation of deep vein thrombosis in lower limbs, and to establish a new thrombosis prediction model for patients with lower limb fractures.
Methods: The patients were divided into DVT group and non DVT group according to whether there was deep vein thrombosis of the lower extremity. The differences in the levels of D-D, FIB, FDP and platelets between the two groups were analyzed and compared.
Arch Phys Med Rehabil
December 2024
Objective: To examine the correlations between individual characteristics among clients with stroke within public vocational rehabilitation (VR) and the employment outcome, as well as the utilization of VR services and their employment outcomes after VR services.
Design: Observational cohort study SETTING: Nationwide vocational rehabilitation data from the Rehabilitation Service Administration Case Service Report (RSA-911) for fiscal year 2022.
Participants: Individuals with stroke as primary cause of disability MAIN OUTCOME MEASURES: employment status and VR service types RESULTS: Of those with stroke who received VR services (n = 1,793), 653 (36.
The Chromodomain Helicase DNA-binding (CHD) protein family is ATP-dependent chromatin remodeling proteins that utilize energy produced by ATP hydrolysis to regulate chromatin structure and thereby modulate gene expression. The earliest report of a CHD3 gene mutation was by O'Roak, who found it during whole exome sequencing of 189 autism families in 2012. In 2018, Snijders Blok systematically assessed the autosomal dominant neurodevelopmental disorder caused by CHD3 gene damage, known as Snijders Blok-Campeau syndrome (SNIBCPS, OMIM 618205).
View Article and Find Full Text PDFFasciclin-like arabinogalactan proteins (FLAs) have been shown to improve plant tolerance to salt stress. However, their role in cold tolerance (CT) remains unclear. Here, we report that banana MaFLA27 positively regulates CT in Arabidopsis.
View Article and Find Full Text PDFAccumulating evidences have indicated that cancer stem cells (CSCs) can initiate tumor progression and cause recurrence after therapy. However, specific markers of gastric CSCs (GCSCs) from different origins have not been comprehensively revealed. Here, we further detected whether cell populations labelled with CD44 and Lgr5, well-recognized stem markers for gastric cancer (GC), can better emphasize cancer initiation, therapeutic resistance and recurrence.
View Article and Find Full Text PDFGroup B Streptococcus is a bacterium that colonizes in approximately 20% of pregnant women and can be vertically transmitted to newborns, leading to maternal-neonatal adverse outcomes, such as chorioamnionitis, neonatal sepsis, and pneumonia. However, there is currently no agreement on the optimal induction method for this specific population. This study aims to evaluate the safety of a single balloon catheter (BC) in comparison to dinoprostone for labor induction in term pregnant women with group B Streptococcus colonization.
View Article and Find Full Text PDFBackground: Peripherally inserted central catheters (PICCs) are commonly used for extended intravenous therapy but are associated with a significant risk of bloodstream infections (BSIs), which increase morbidity and healthcare costs.
Aim: The aim of this study was to identify patients at high risk of developing PICC-related bloodstream infections (PICC-RBSIs) to establish new and more specific targets for precise prevention and intervention.
Methods: A search was conducted from the earliest available record to May 2024 among the following databases: Embase, MEDLINE, Cochrane Central Register of Controlled Trials, Cumulative Index to Nursing and Allied Health Literature (CINAHL), Web of Science, Scopus, and Chinese National Knowledge Infrastructure (CNKI).
Continuous monitoring of nocturnal blood pressure is crucial for hypertension management and cardiovascular risk assessment. However, current clinical methods are invasive and discomforting, posing challenges. These traditional techniques often disrupt sleep, impacting patient compliance and measurement accuracy.
View Article and Find Full Text PDFBackground: We attempted to establish correlations between intraoperative variables such as time-to-isolation (TTI) and temperature (T) at the 30-second mark, and the sustained efficacy of pulmonary vein isolation.
Methods: One hundred patients underwent repeat procedures subsequent to their index ablation. Five time intervals were delineated based on TTI metrics of 30, 35, 40, 45, and 60 s during the initial procedure.
Purpose: To assess the correlation of body mass index (BMI), diet and lifestyle with allergic conjunctivitis (AC) in children.
Methods: This prospective case-control study included 105 children with AC and 105 age- and sex-matched children with no AC. Clinical data were collected, including BMI, dietary habits, physical activity, and sleep time.
Cancer Epidemiol Biomarkers Prev
December 2024
Background: African American (AA) men are at increased risk of prostate cancer (PCa) compared to men of European ancestry (EA). Biological mechanisms, including epigenetics, likely contribute to this disparity, but prior studies have been limited by sample size, candidate gene approaches, or lack of epigenome-wide DNA methylation (DNAm) data.
Methods: To improve our understanding of these mechanisms, we compared DNAm features distinguishing tumor and paired histologically benign tissue from 76 AA and 75 EA PCa patients.
Infect Agent Cancer
December 2024
Background/aims: microRNAs (miRNAs) contribute to tumorigenesis, progression and drug resistance of hepatocellular carcinoma (HCC). miR-3191 is a newly discovered miRNA, and its function and mechanism of action in biological processes and diseases are not completely understood.
Methods: miR-3191 expression is determined via quantitative real-time polymerase chain reaction.
Background: The subtypes diagnosis of disease symptom clusters, grounded in the theory of "Treatment in Accordance with Three Categories of Etiologic Factors" and International Classification of Diseases 11th Revision (ICD-11), is a vital strategy for Chinese Medicine (CM) in treating unknown respiratory infectious diseases. However, the classification of disease symptom clusters continues to depend on empirical observations and lacks robust scientific evidence. Consequently, this study seeks to explore the temporal, spatial and demographic distributions characteristics of Corona Virus Disease 2019 (COVID-19) symptom clusters in China.
View Article and Find Full Text PDFBackground: Prolonged postoperative ileus (PPOI) reportedly leads to compromised postoperative recovery and increased healthcare costs. However, the evidence for this claim was obtained from studies that included patients with both primary and secondary PPOI. How primary PPOI affects the hospital length of stay (LOS) and healthcare costs is not well documented.
View Article and Find Full Text PDFThe evolution of energy structure and the push for carbon neutrality have triggered an urgent call for lithium-ion batteries (LIBs). However, reclaiming end-of-life LIBs with high purity, high efficiency, and low environmental impact, particularly by eliminating chemical reagent usage and promoting a closed-loop carbon footprint, is challenging. Herein, we proposed a strategy that couples the carbon capture (CC) process with an electrochemically enhanced membrane distillation system (ECMD).
View Article and Find Full Text PDFBackground: This study aimed to explore the mechanism by which HIV infection promotes cervical cancer and precancerous lesions.
Methods: This was a retrospective observational study including 96 patients with high-risk HPV-16 infection who underwent cervical biopsy, cervical conization, or hysterectomy. Among them, 43 patients were diagnosed with both HIV and cervical cancer or precancerous lesions.
Biochim Biophys Acta Mol Basis Dis
December 2024
The integrity of the endothelial monolayer is critical for preventing life-threatening hemorrhaging and thrombosis. However, how severe endothelium-denuded injury is rapidly repaired remains unknown. Given the common biological properties between endothelial cells and circulating monocytes, we aimed to examine whether blood monocytes are involved in endothelium wound healing.
View Article and Find Full Text PDFWe report a step-economic strategy for the direct synthesis of novel polycyclic -heterocycle-fused naphthoquinones by merging intramolecular oxidative coupling and cascade [4 + 2] cycloaddition. In the protocol, mechanistic investigations suggest that the cascade reaction involves the intermediate spiro polycyclic -heterocycles and [4 + 2] cycloaddition processes. This protocol is featured with moderate to excellent yields, wide substrate scope, and divergent structures of products.
View Article and Find Full Text PDFObjective: Hepatocellular carcinoma (HCC) presents substantial genetic and phenotypic diversity, making it challenging to predict patient outcomes. There is a clear need for novel biomarkers to better identify high-risk individuals. Long non-coding RNAs (lncRNAs) are known to play key roles in cell cycle regulation and genomic stability, and their dysregulation has been closely linked to HCC progression.
View Article and Find Full Text PDFInbreeding increases genome homozygosity within populations, which can exacerbate inbreeding depression by exposing homozygous deleterious alleles that are responsible for declines in fitness traits. In small populations, genetic purging that occurs under pressure of natural selection acts as an opposing force, contributing to a reduction of deleterious alleles. Both inbreeding and genetic purging are paramount in the field of conservation genomics.
View Article and Find Full Text PDFMicroorganisms play dual roles in soil organic carbon (SOC) decomposition and accumulation. Despite advancing insights into their involvement in the carbon cycle, understanding the impact of microbial community structure and physiological traits on SOC stabilization in arid and semi-arid grasslands remains elusive. Here, we analyzed arid and semi-arid grasslands SOC stability by comparing the ratio of mineral-associated organic carbon (MAOC) to particulate organic carbon (POC) across a grassland transect in north-south Ningxia, encompassing various grassland types and a broad climatic gradient (ΔMAP = 450 mm).
View Article and Find Full Text PDFAs a rate-limiting enzyme in endogenous serine de novo synthesis pathway, PHGDH has been widely concerned about its role in a variety of tumors including colon cancer and the development of inhibitors. In our previous study, we studied PHGDH in colon cancer cell lines. However, with the development of personalized therapy, we realized that in scientific research, 2D cell lines lost a lot of original characteristic information during long-term culture, and the results obtained may not be enough to support the conclusion.
View Article and Find Full Text PDFRh-hydride phases were believed to be key causes of the exceptional catalytic ability of Rh catalysts under H reductive conditions. Here, we utilize the large-scale machine-learning-based global optimization to explore millions of Rh bulk, surface, and nanoparticle structures in contact with H, which rules out the presence of subsurface/interstitial H in Rh and Rh-hydride phases as thermodynamically stable phases under ambient conditions. Instead, an exceptional Rh-H affinity is identified for surface Rh atoms in Rh nanoparticles that can accommodate a high concentration of adsorbed H, with the surface Rh to H ratio reaching ∼2.
View Article and Find Full Text PDFBackground: Epidermal growth factor receptor (EGFR) is a key protein in cellular signaling that is overexpressed in many human cancers, making it a compelling therapeutic target. On-target severe skin toxicity has limited its clinical application. Dual-targeting therapy represents a novel approach to overcome the challenges of EGFR-targeted therapies.
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