Publications by authors named "Limor Shomonov-Wagner"
Article Synopsis
- Maternal diets rich in α-linolenic acid (ALA) during pregnancy and lactation can prevent lipid metabolic disorders in offspring, as opposed to those fed a diet high in saturated fatty acids (SFA).
- The study involved analyzing the liver gene expression of newborn mice from mothers on either an ALA or SFA diet, revealing significant changes in gene regulation and liver fat composition.
- Results showed that ALA increased levels of beneficial fatty acids and specifically upregulated genes associated with lower fat accumulation, while SFA had the opposite effect on gene expression.
Background: Alpha linolenic acid (ALA, 18:3) in maternal diets has been shown to attenuate obesity associated insulin resistance (IR) in adult offspring in mice. The objective in the present study was to detect the early effects of maternal dietary saturated fatty acids (SFA) and their partial substitution with ω-3 ALA, docosa hexenoic acid (DHA,22:6) and eicosapentenoic acid 20:5 (EPA,20:5) on the HOMA index, liver lipids and fatty acid desaturases in the offspring at weaning.
Methods: 3 month old C57Bl6/J female mice were fed diets containing normal amount of calories but rich in SFA alone or partially replaced with ALA, DHA or EPA before mating, during pregnancy and lactation.