CTP-defined collaterals is a better predictor of intracranial atherosclerotic stenosis-related large-vessel occlusion than multiphase CTA-defined collaterals.

The optimal neuroimaging modalities for differentiating intracranial atherosclerotic stenosis-related large vessel occlusion (ICAS-LVO) from embolism related LVO remain uncertain. This study aimed to address this question by directly comparing collateral circulation using either baseline CT perfusion (CTP) or multiphase CT angiogram (mCTA) to define collaterals. We retrospectively analyzed consecutive patients with acute large vessel occlusion from October 2021 to December 2023.

Stenting for Symptomatic Severe Intracranial Arterial Stenosis with Downstream Perfusion Deficit in Anterior Circulation: A Retrospective Propensity-Matched Study.

Purpose: The purpose of this study is to investigate whether patients with symptomatic severe intracranial atherosclerotic stenosis (ICAS) and downstream perfusion deficit could benefit from adding percutaneous transluminal angioplasty and stenting (PTAS) to medical therapy.

Materials And Methods: We retrospectively reviewed patients with symptomatic severe ICAS and an Alberta Stroke Program Early CT score of < 6 on mean transit time map who received either medical plus PTAS therapy (PTAS group) or medical therapy alone (medical group) between January 2016 and December 2019 at a single center. After 1:1 propensity score matching, we analyzed the primary outcome-cumulative event rate (defined as ischemic stroke in the qualifying artery)-along with four secondary outcomes (any intracranial hemorrhage within 30 days; disabling stroke or death; any stroke, transient ischemic attack, or cardiovascular events; and death by the end of follow-up).

Research on maximum power point tracking of photovoltaic power generation based on improved hybrid optimization algorithm.

Due to environmental factors' influence, the power-voltage (P-V) curve of a photovoltaic array typically presents multiple peaks. The traditional gravitational search algorithm is inclined to fall into local optimal solutions and demonstrates poor performance in maximum power point tracking. Consequently, this paper proposes applying the PSO algorithm for optimizing the GSA parameters.

Effects of Prophylactic Coil Embolization of Pelvic Arteries on Surgical Outcomes in Hemodynamically Stable Patients with Complex Acetabular Fractures.

Purpose: To investigate the effectiveness of prophylactic embolization of the internal iliac artery (IIA) or superior gluteal artery (SGA) before open reduction and internal fixation (ORIF) in reducing intraoperative blood loss (IBL) in hemodynamically stable patients with complex acetabular fractures.

Materials And Methods: A total of 136 patients with complex acetabular fractures were retrospectively included and divided into the prophylactic transcatheter arterial embolization (PTAE) group and non-PTAE group, depending on whether ipsilateral IIA or SGA was embolized using coils within 3 days before ORIF. Demographic characteristics, injury severity score, fracture classification, and intraoperative and postoperative data were compared between the 2 groups.

Influence of Aging Treatment and Volume Fraction on Nano-Indentation Behavior of Ni-Based Single Crystal Superalloys.

The effects of aging treatment and the volume fraction of precipitation particles on the nano-hardness and nano-indentation morphology of Ni-based single crystal superalloys are systematically investigated. Using nano-indentation tests and atomic force microscopy (AFM), this study examined the mechanical properties and related physical mechanisms of Ni-based superalloys that have two volume fractions of precipitation particles and four aging treatment times. Results analyzed using the Oliver-Pharr method indicate that prolonging the aging time or increasing the volume fraction of particles enhances the nano-hardness and creep resistance of Ni-based single crystal superalloys and reduces the indentation-affected area.

Accuracy and Value of Time-resolved MRA for Spinal Vascular Malformations.

Study Design: Retrospective.

Objective: To explore the value of time-resolved CE-MRA in evaluating and locating the SVM prior to digital subtraction angiography (DSA).

Summary Of Background Data: Spinal vascular malformations (SVM) can be detected with time-resolved contrast-enhanced MRA(CE-MRA).

Research on photovoltaic MPPT under complex conditions based on an advanced great wall construction algorithm method.

To mitigate the challenges posed by the non-linear multi-peak power-voltage output characteristics of photovoltaic (PV) systems operating under partial shading conditions, which often lead to suboptimal performance of conventional Maximum Power Point Tracking (MPPT) algorithms, a novel approach was introduced. We introduce the LGWGCA-P&O method, which synergistically combines an modified Great Wall Construction Algorithm (LGWGCA) with the Perturbation and Observation (P&O) technique. The LGWGCA is refined with a positional update mechanism inspired by the Grey Wolf Optimization (GWO) algorithm, optimizing the distribution of solution agents, while a Levy flight strategy is employed to reduce excessive randomness during agent replacement and recombination, thereby accelerating the tracking process.

Neuroprotective Effects of Rapid Local Ischemic Postconditioning in Successful Endovascular Thrombectomy Patients.

Background: We aim to assess the efficacy of rapid local ischemic postconditioning (RL-IPostC) following successful reperfusion in patients with acute ischemic stroke with anterior circulation large vessel occlusion who underwent endovascular thrombectomy.

Methods: We conducted an ambidirectional cohort study with 78 prospectively enrolled patients with RL-IPostC and endovascular thrombectomy and 129 retrospectively enrolled patients with endovascular thrombectomy. The RL-IPostC procedure involved 5 cycles of 15-s balloon inflation and deflation in the ipsilateral internal carotid artery.

A Powerful Strategy for Carbon Reduction: Recyclable Mono-Material Polyethylene Functional Film.

Given the abundant plastics produced globally, and the negative environmental impacts of disposable plastic products throughout their life cycle, there has been significant attention drawn by the general public and governments worldwide. Mono-material multilayer packaging is a potent strategy to address the challenge of carbon emissions as it offers specific functionalities (such as strength and barrier properties) through its layers and facilitates recycling. In this study, a five-layer co-extruded polyethylene composite film LLDPE/mPE/PVA/mPE/LLDPE was taken as a model to investigate its mechanical properties and barrier properties after four recycling cycles.

Tanshinone IIA Regulates Synaptic Plasticity in Mg-Free-Induced Epileptic Hippocampal Neurons via the PI3K/Akt Signaling Pathway.

Background: Tanshinone IIA (TSIIA) is an element of the effective ingredients of Bunge (Labiatae), exhibits a significant therapeutic effect in brain neuroprotection. The focus of this study was the examination of synaptic plasticity of in Mg2+-free-induced epileptic hippocampus neurons and how TSIIA protects against it.

Methods: The purity of the primary hippocampal neurons extracted from Sprague Dawley rats was assessed within 24 hours by microtubule-associated protein (MAP2) immunofluorescence staining.

Safety and efficacy of protective stent insertion to prevent carotid blowout syndrome at the distal internal carotid artery in nasopharyngeal carcinoma patients: a comparison with endovascular occlusion.

Background: Carotid blowout syndrome (CBS) frequently occurs at the distal internal carotid artery (distal-ICA) in patients with nasopharyngeal carcinoma (NPC), and remedial treatments run a high risk for neurologic complications. A case-control study was conducted to evaluate the safety and efficacy of protective stent insertion at the distal-ICA to prevent CBS in NPC patients, with a comparison to endovascular coil occlusion.

Methods: A total of 28 consecutive NPC patients at high risk of CBS from June 2019 to December 2021 in Shanghai Sixth People's Hospital (a tertiary institution) were retrospectively included and divided into a stent protection group and occlusion group.

Experimental Investigation of Current Intensity and Feed Speed in Electrically Assisted Necking and Thickening of 5A02 Aluminum Alloy Tubes.

In order to further explore the forming limits of thin-wall tube necking and thickening, and obtain sufficient thickness of the tube in the thickening area, local electric pulse-assisted forming experiments were carried out to study the effects of current intensity and feed speed on the necking and thickening forming of thin-wall tube. The experimental results show that with the increase in current intensity, the temperature in the forming area of the tube increases, and the forming load for necking and thickening decreases. However, with the increase in feed speed, the overall forming load for necking and thickening increases in general, and the smaller feed speed is more conducive to forming.

Optimization of building integrated energy scheduling using an improved genetic whale algorithm.

Renewable energy generation has become the general trend with increasing environmental problems. However, the instability of renewable energy generation and the diversification of user demand are highlighted and the optimization of energy scheduling has become the key to solve the problem. This study introduces an energy scheduling optimization model tailored for building integrated energy systems, encompassing elements like gas turbines, wind and solar modules, ground source heat pumps, electric vehicles, central air-conditioning, and energy storage.

Transcriptome Analysis Reveals Drought-Responsive Pathways and Key Genes of Two Oat () Varieties.

To cope with the yield loss caused by drought stress, new oat varieties with greater drought tolerance need to be selected. In this study, two oat varieties with different drought tolerances were selected for analysis of their phenotypes and physiological indices under moderate and severe soil drought stress. The results revealed significant differences in the degree of wilting, leaf relative water content (RWC), and SOD and CAT activity between the two oat genotypes under severe soil drought stress; moreover, the drought-tolerant variety exhibited a significant increase in the number of stomata and wax crystals on the surface of both the leaf and guard cells; additionally, the morphology of the guard cells was normal, and there was no significant disruption of the grana lamella membrane or the nuclear envelope.

Impact of leukoaraiosis on the infarct growth rate and clinical outcome in acute large vessel occlusion stroke after endovascular thrombectomy.

Introduction: As a marker of chronic cerebral small vessel disease, leukoaraiosis (LA) was reported to impact the recruitment of collaterals in acute ischemic stroke (AIS). We intended to explore the impact of LA on the infarct growth rate (IGR) and clinical outcome by impaired collateral development in AIS patients with large vessel occlusion (LVO) who underwent endovascular thrombectomy (EVT).

Patients And Methods: Two hundred thirty-six AIS patients who underwent EVT were retrospectively reviewed.

Elucidation of -/-glycosylation and site-specific mapping of sialic acid linkage isomers of SARS-CoV-2 human receptor angiotensin-converting enzyme 2.

Human angiotensin-converting enzyme 2 (hACE2) is the primary receptor for cellular entry of SARS-CoV-2 into human host cells. hACE2 is heavily glycosylated and glycans on the receptor may play a role in viral binding. Thus, comprehensive characterization of hACE2 glycosylation could aid our understanding of interactions between the receptor and SARS-CoV-2 spike (S) protein, as well as provide a basis for the development of therapeutic drugs targeting this crucial interaction.

IgG glycomic profiling identifies potential biomarkers for diagnosis of echinococcosis.

Echinococcosis caused by larval stage of the genus Echinococcus, is a serious and potentially fatal parasitic zoonosis distributed globally. The two types of the disease in human are cystic echinococcosis (CE) and alveolar echinococcosis (AE). As the biological and encysting characteristics of the parasite, early diagnosis remains to address.

Iron homeostasis imbalance and ferroptosis in brain diseases.

Brain iron homeostasis is maintained through the normal function of blood-brain barrier and iron regulation at the systemic and cellular levels, which is fundamental to normal brain function. Excess iron can catalyze the generation of free radicals through Fenton reactions due to its dual redox state, thus causing oxidative stress. Numerous evidence has indicated brain diseases, especially stroke and neurodegenerative diseases, are closely related to the mechanism of iron homeostasis imbalance in the brain.

Thrombus Enhancement Sign May Differentiate Embolism From Arteriosclerosis-Related Large Vessel Occlusion.

Background And Purpose: To evaluate whether the thrombus enhancement sign (TES) can be used to differentiate embolic large vessel occlusion (LVO) from in situ intracranial atherosclerotic stenosis (ICAS)-related LVO in the anterior circulation of patients with acute ischemic stroke (AIS).

Methods: Patients with LVO in the anterior circulation who underwent both non-contrast computed tomography (CT) and CT angiography and mechanical thrombectomy were retrospectively enrolled. Both embolic LVO (embo-LVO) and in situ ICAS-related LVO (ICAS-LVO) were confirmed by two neurointerventional radiologists after reviewing the medical and imaging data.

Core overestimation of CT perfusion in patients with cardiac insufficiency who had a stroke is mediated by impaired collaterals.

Background: We hypothesized that left ventricular systolic dysfunction (LVSD) would lead to an ischemic core overestimation in patients with acute ischemic stroke (AIS), and impaired collateral status might partly mediate this effect.

Objective: A pixel-based analysis of CT perfusion (CTP) and follow-up CT was undertaken to investigate the optimum CTP thresholds for the ischemic core if overestimation was found.

Methods: A total of 208 consecutive patients with AIS with large vessel occlusion in the anterior circulation, who received initial CTP evaluation and successful reperfusion, were retrospectively analyzed and divided into an LVSD (left ventricular ejection fraction (LVEF) ratio <50%; n=40) and a normal cardiac function (LVEF≥50%; n=168) group.

Investigation of the mechanism of tanshinone IIA to improve cognitive function via synaptic plasticity in epileptic rats.

Context: Tanshinone IIA is an extract of Bunge (Labiatae) used to treat cardiovascular disorders. It shows potential anticonvulsant and cognition-protective properties.

Objective: We investigated the mechanism of tanshinone IIA on antiepileptic and cognition-protective effects in the model of epileptic rats.

Clot-based radiomics model for cardioembolic stroke prediction with CT imaging before recanalization: a multicenter study.

Objectives: To develop a clot-based radiomics model using CT imaging radiomic features and machine learning to identify cardioembolic (CE) stroke before mechanical thrombectomy (MTB) in patients with acute ischemic stroke (AIS).

Materials And Methods: This retrospective four-center study consecutively included 403 patients with AIS who sequentially underwent CT and MTB between April 2016 and July 2021. These were grouped into training, testing, and external validation cohorts.