Effect of Welding Speed on Microstructure Evolution and Mechanical Properties of Friction Stir Welded 2198 Al-Cu-Li Alloy Joints.

In the present study, 2198 Al-Cu-Li alloys were successfully friction stir welded by using various welding speed ranges of 90~180 mm/min with an invariable rotation speed of 950 r/min. The effect of welding speed on microstructure evolution and mechanical properties of the joints was investigated. The results show that, with the welding speed decreasing, the size of the nugget zone (NZ) first increases and then decreases due to different welding temperatures.

Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis.

Triple-negative breast cancer (TNBC) is an aggressive histological subtype of breast cancer. It has been reported that the circular RNA (circRNA) circ-ERBB2 (circBase identifier hsa_circ_0007766) is mainly distributed in the cytoplasm of TNBC cells and promotes the proliferation and invasion of TNBC cells. This study aimed to explore the molecular mechanism of circ-ERBB2 regulating the progression of TNBC.

Formation Investigation of Intermetallic Compounds of Thick Plate Al/Mg Alloys Joint by Friction Stir Welding.

5A06 Aluminum (Al) alloy and AZ31B magnesium (Mg) alloy with 20 mm thickness were successfully butt joined by friction stir welding. In order to control the composition of Al and Mg alloys along thickness direction, an inclined butt joint was designed in this study. The microstructure and phase identification at the interface of Al/Mg joints were examined using scanning electron microscopy with an energy-dispersive spectroscopy and Micro X-ray diffraction.

The Martensitic Transformation and Mechanical Properties of Ti6Al4V Prepared via Selective Laser Melting.

This article investigated the microstructure of Ti6Al4V that was fabricated via selective laser melting; specifically, the mechanism of martensitic transformation and relationship among parent β phase, martensite (α') and newly generated β phase that formed in the present experiments were elucidated. The primary X-ray diffraction (XRD), transmission electron microscopy (TEM) and tensile test were combined to discuss the relationship between α', β phase and mechanical properties. The average width of each coarse β columnar grain is 80⁻160 μm, which is in agreement with the width of a laser scanning track.

Microstructure and Mechanical Properties of 34CrNiMo6 Steel Repaired by Friction Stir Processing.

Repairing damaged parts using proper repairing methods has become an important means to reduce manufacturing and operational costs and prolong the service life of 34CrNiMo6 steel structures. In the conventional fusion repairing method, welding wire and powder are often used as filling materials. Filling materials are often expensive or difficult to find.

Development, characterization and anti-tumor effect of a sequential sustained-release preparation containing ricin and cobra venom cytotoxin.

Cobra venom cytotoxin (CVC) loaded in poly (lactide-co-glycolide) (PLGA) microspheres was mixed with ricin and encapsulated in a thermosensitive PLGA-PEG-PLGA hydrogel for this study. This sequential sustained-release preparation (SSRP) containing ricin and CVC could avoid burst release effect of CVC from microspheres. In addition, in SSRP, the two biotoxins have different drug release rates and antitumor mechanisms, which can be complementary to each other.

Chemotherapy with PLGA microspheres containing docetaxel decreases angiogenesis in human hepatoma xenograft.

To investigate the antiangiogenic effect of sustained-release poly (lactic-co-glycolic acid) microspheres containing docetaxel (PMCD) in human hepatoma xenograft. PMCD were prepared by solvent evaporation method with an encapsulation efficiency of 98.7% and a release period of about 3 weeks in vitro.