The impact of the National Syphilis Prevention Program on the prevalence of syphilis among people living with HIV in China: a systematic review and meta-analysis.

Introduction: In 2010, China launched the 10-year National Syphilis Prevention and Control Program to curb the spread of syphilis by integrating syphilis screening and treatment with HIV services. Herein, we aimed to evaluate changes in the prevalence of syphilis among people living with HIV (PLHIV) in China.

Methods: We conducted this systematic review and meta-analysis by searching the PubMed, Embase, Web of Science, China Biomedical Literature, China National Knowledge Infrastructure, Wanfang and CQVIP databases from inception to 1 June 2024 to obtain relevant articles.

Application of big data technology in enterprise information security management.

This study aims to explore the application value of big data technology (BDT) in enterprise information security (EIS). Its goal is to develop a risk prediction model based on big data analysis to enhance the information security protection capability of enterprises. A big data analysis system that can monitor and intelligently identify potential security risks in real-time is constructed by designing complex network analysis algorithms and machine learning models.

Quantitative source apportionment and health risk assessment for polycyclic aromatic hydrocarbon and their derivatives in indoor dust from housing and public buildings of a mega-city in China.

Indoor dust can adsorb various pollutants and long-term deposition can significantly impact air quality and human health. This study investigated the occurrence, source apportionment, and health risks associated with polycyclic aromatic hydrocarbons (PAHs) and their derivatives (d-PAHs) in indoor dust, by focusing on residential and public buildings in Nanjing, China. The concentration of 16 PAHs and 27 d-PAHs ranged from 511 to 5472 ng/g and from 422 to 2904 ng/g, with the most abundant compounds being fluoranthene and 1,2-benz[a]anthraquinone, respectively.

Isolation, Identification, and Fermentation Optimization of Phytase-Producing Bacteria and Their Effects on Soybean Seedlings.

Phosphorus in soil mostly exists in complex compounds such as phytic acid, which reduces the effectiveness of phosphorus and limits agricultural production. Phytase has the activity of hydrolyzing phytate into phosphate. The mineralization of phytate in soil by phytase secreted by microorganisms is an effective way to improve the utilization rate of phytate.

Effects of exercise based cardiac rehabilitation delivery modes on chronic heart failure: a systematic review and network meta-analysis.

Chronic heart failure (CHF) represents one of the most severe and advanced stages of cardiovascular disease. Despite the critical importance of cardiac rehabilitation (CR) in CHF management, while studies have explored the effectiveness of various CR delivery modes and offered valuable context-specific insights, their relative efficacy remains inconsistent across different patient groups, healthcare environments, and intervention approaches. A clearer understanding requires comprehensive comparisons and in-depth analyses to address these variations.

Accurate prediction of pollution and health risks of iodinated X-ray contrast media in Taihu Lake with machine learning and revealing key environmental factors.

Iodinated X-ray contrast media (ICM) are commonly detected at considerable concentrations in aquatic environments. The long-term pollution trends in ICM at the whole lake/river scale have not yet been investigated; therefore, the risks associated with ICM and the influences of environmental factors remain understudied. Herein, the occurrence and distribution of ICM in the surface water of Taihu Lake were comprehensively investigated.

[Transition of Food Consumption Patterns and Carbon Footprint of Urban and Rural Residents in China].

The food system is an important source of greenhouse gas emissions, and the carbon footprint analysis of food consumption under the dual carbon background is of great significance for the sustainable development of the food system. To reveal the differences in food consumption patterns and carbon footprints between urban and rural residents in China, the life cycle carbon emission coefficient method was used to measure the direct carbon emissions of food consumption by urban and rural residents in China from 2000 to 2021. From the perspective of carbon footprint composition, the following main conclusions were drawn： ① The structure of food consumption among residents in China shifted from predominantly plant-based to a balanced consumption of both plant- and animal-based foods, reducing the disparity in various food consumption quantities between urban and rural residents.

Effects of EDTA and Bicarbonate on U(VI) Reduction by Reduced Nontronite.

Widespread Fe-bearing clay minerals are potential materials capable of reducing and immobilizing U(VI). However, the kinetics of this process and the impact of environmental factors remain unclear. Herein, we investigated U(VI) reduction by chemically reduced nontronite (rNAu-2) in the presence of EDTA and bicarbonate.

NaHS alleviates neuropathic pain in mice by inhibiting IL-17-mediated dopamine (DA) neuron necroptosis in the VTA.

Background: Neuropathic pain (NP) constitutes a significant burden for individuals, manifesting as nociceptive anaphylaxis, hypersensitivity, and spontaneous pain. Previous research has suggested that the analgesic effects of NP are mediated by dopamine (DA) neurons in the ventral tegmental region (VTA) through projections to various brain regions. A decrease in VTA dopamine neurons following NP may contribute to prolonged pain.

Dual relaxation behaviors driven by a homogeneous and stable dual-interface charge layer based on an EGaIn absorber.

Interface engineering, by modulating defect distribution and impedance at interfaces and inducing interfacial polarization, has proven to be an effective strategy for optimizing dielectric properties. However, the inherent incompatibility between heterogeneous phases presents a significant challenge in constructing multi-heterointerfaces and understanding how their distribution influences dielectric performance. Herein, we constructed an EGaIn@Ni/NiO/GaO composite structure by employing a low-intensity ultrasound-assisted galvanic replacement reaction followed by high-temperature annealing.

Polymorphic low-grade neuroepithelial tumors of the young: disease characteristics and treatment decisions from the epilepsy surgery perspective.

Background: The Polymorphic Low-Grade Neuroepithelial Tumor of the Young (PLNTY) is a rare, epilepsy-associated brain tumor that has been increasingly recognized but is not well understood due to the scarcity of clinical reports. Our study reviews the clinical characteristics and treatment outcomes of 14 patients with PLNTY to enhance the understanding of this condition from an epilepsy surgery perspective.

Methods: We performed a retrospective analysis of 14 PLNTY cases at our hospital.

Tumor-derived miR-9-5p-loaded EVs regulate cholesterol homeostasis to promote breast cancer liver metastasis in mice.

Cancer cells secrete extracellular vesicles (EV) encapsulating bioactive cargoes to facilitate inter-organ communication in vivo and are emerging as critical mediators of tumor progression and metastasis, a condition which is often accompanied by a dysregulated cholesterol metabolism. Whether EVs are involved in the control of cholesterol homeostasis during tumor metastasis is still undefined and warrant further investigation. Here, we find that breast cancer-derived exosomal miR-9-5p induces the expression of HMGCR and CH25H, two enzymes involved in cholesterol synthesis and the conversion of 25-hydroxycholesterol from cholesterol by targeting INSIG1, INSIG2 and ATF3 genes in the liver.

High-Density Dual Atoms Pairs Coupling for Efficient Electromagnetic Wave Absorbers.

Dual atoms (DAs), characterized by flexible structural tunability and high atomic utilization, hold significant promise for atom-level coordination engineering. However, the rational design with high-density heterogeneous DAs pairs to promote electromagnetic wave (EMW) absorption performance remains a challenge. In this study, high-density Ni─Cu pairs coupled DAs absorbers are precisely constructed on a nitrogen-rich carbon substrate, achieving an impressive metal loading amount of 4.

Highly Mixed Index Facet Engineering Induces Defect Formation and Converts the Wave-Transmissive Mott Insulator NiO into Electromagnetic Wave Absorbent.

Mott insulator possesses the property of converting into semiconductor under supernormal conditions and achieving the Mott insulator-semiconductor transition (IST) holds great scientific value. Nevertheless, current IST methodologies possess certain limitations because they are not capable of being implemented under conventional conditions, thereby limiting their practical applications. Herein, a highly mixed index facets (HMIF) strategy is proposed to construct homogeneous interfaces with gradient work function (WF) in Mott insulator NiO, accompanied by numerous oxygen vacancies.

Resveratrol attenuates Cr(VI)-induced disorders of glycolipid metabolism by regulating HNF1b/GPX1 in mice.

Epidemiological studies have indicated that exposure to hexavalent chromium (Cr(VI)) is associated with increased morbidity in the population. Resveratrol (Res) is a polyphenolic compound known for its role in mitigating oxidative stress and inflammation. In this study, we investigated the effects of resveratrol on Cr(VI)-induced disorders of glycolipid metabolism and elucidated its mechanisms.

Harnessing Cross-strand π-π Interlocking for Synergistic Enhancement of Immune Checkpoint Blocking and Ferroptosis.

The dynamic nature of noncovalent bonds in peptide self-assembly allows for selective accommodation of guest molecules. However, it remains unclear how to harness coassembly to reinforce the host peptides and simultaneously improve the application defects of guest molecules. This study aims to achieve supramolecular synergy between the host and guest, further expanding the functional space of the hybrid nanostructures.

Enhanced Molecular Imaging through a Versatile Peptide Nanofiber for Self-Assembly and Precise Recognition.

Designing molecules for multivalent targeting of specific disease markers can enhance binding stability which is critical in molecular imaging and targeted therapy. Through rational molecular design, the nanostructures formed by self-assembly of targeting peptides are expected to achieve multivalent targeting by increasing the density of recognition ligands. However, the balance between targeting peptide self-assembly and molecular recognition remains elusive.

pscAdapt: pre-trained domain adaptation network based on structural similarity for cell type annotation in single cell RNA-seq data.

Cell type annotation refers to the process of categorizing and labeling cells to identify their specific cell types, which is crucial for understanding cell functions and biological processes. Although many methods have been developed for automated cell type annotation, they often encounter challenges such as batch effects due to variations in data distribution across platforms and species, thereby compromising their performance. To address batch effects, in this study, a pre-trained domain adaptation model based on structural similarity, named pscAdapt, is proposed for cell type annotation.

Assessment of perineal body properties in women with stress urinary incontinence using Transperineal shear wave elastography.

Limited data on the correlation between the perineal body (PB) and stress urinary incontinence (SUI) are available. The objectives of this study were to quantify the PB using shear wave elastography (SWE) technology with a high-frequency linear array probe to evaluate the relationship between the properties of PB and stress urinary incontinence (SUI). This study included 64 women with SUI and 70 female control participants.