Discovery of Pteridine-7(8)-one Derivatives as Potent and Selective Inhibitors of Bruton's Tyrosine Kinase (BTK).

Bruton's tyrosine kinase (BTK) is an attractive therapeutic target in the treatment of cancer, inflammation, and autoimmune diseases. Covalent and noncovalent BTK inhibitors have been developed, among which covalent BTK inhibitors have shown great clinical efficacy. However, some of them could produce adverse effects, such as diarrhea, rash, and platelet dysfunction, which are associated with the off-target inhibition of ITK and EGFR.

Enhanced cyclability of Li-O batteries with cathodes of Ir and MnO supported on well-defined TiN arrays.

The cycling stability of Li-O batteries has been impeded by the lack of high-efficiency, and durable oxygen cathodes for the oxygen-reduction reaction (ORR) and the oxygen-evolution reaction (OER). Herein we report a novel TiN nanorod array-based cathode, which was firstly prepared by growing a TiN nanorod array on carbon paper (CP), and then followed by depositing MnO ultrathin sheets or Ir nanoparticles on the TiN nanorods to form well-ordered, three-dimensional (3D), and free-standing structured cathodes: TiN@MnO/CP and TiN@Ir/CP. Both cathodes exhibited good specific capacity and excellent cycling stability.