Efficient photocatalytic degradation of antibiotics using Z-scheme MIL-88(Fe)/TiC/MoO: Mechanistic insights and toxicity assessment.

Antibiotic residues cause water contamination and disrupt aquatic ecosystems. Herein, we reported the fabrication of a novel Z-scheme heterojunction, MIL-88A(Fe)/TiC/MoO (MTO), for safe and efficient removal of antibiotics. TiC was introduced into the MIL-88A(Fe)/MoO (MO) heterojunction as an electronic mediator to accelerate charge separation.

Multi-segment cooling design of a reflection mirror based on the finite-element method.

High-repetition-rate free-electron lasers impose stringent requirements on thermal deformations of optics in the beamline. The Shanghai HIgh-repetition-rate XFEL aNd Extreme light facility (SHINE) experiences high average thermal power and demands wavefront preservation. To effectively manage thermal deformation in the first reflection mirrors M1, we optimized the cooling length and position of the cooling groove with numerical calculations.

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) and nutrients from two constructed wetlands in a city of southeastern China.

Perfluoroalkyl and polyfluoroalkyl substances (PFAS) are a large class of toxic contaminants. Nutrients are closely related to the ecological health of aquatic systems. Both have received widespread global attention.

Cell membrane-functionalized bismuth oxyiodide nanodots as potential contrast agent for gastrointestinal tract imaging.

Various noninvasive imaging modalities, including X-ray and computed tomography (CT) imaging, have provided significant advantages in accurately assessing the conditions of the gastrointestinal (GI) tract. The corresponding contrast agent with high resolution and biosafety is one of the most crucial focuses in the diagnosis of GI diseases. In this study, considering the requirements of good biocompatibility and biosafety, a novel imaging platform composed of the high-performance contrast agent based on macrophage membrane-coated BiOI nanodots (BiOI@M) was designed via a facile approach.

Genome Sequencing Analysis of a Rare Case of Blood Infection Caused by Flavonifractor plautii.

BACKGROUND Flavonifractor plautii belongs to the clostridium family, which can lead to local infections as well as the bloodstream infections. Flavonifractor plautii caused infection is rarely few in the clinic. To understand better Flavonifractor plautii, we investigated the drug sensitivity and perform genome sequencing of Flavonifractor plautii isolated from blood samples in China and explored the drug resistance and pathogenic mechanism of the bacteria.

Signal amplified colorimetric nucleic acid detection based on autocatalytic hairpin assembly.

Herein, a nucleic acid assay based on autocatalytic hairpin assembly (ACHA) was proposed. In this system, two split G-quadruplex sequences were integrated into H1 and H2, respectively. And a DNA strand with the same sequence to target DNA was integrated into the assistant hairpin H3.

Integrated transcriptomic and proteomic analyses uncover the early response mechanisms of Catharanthus roseus under ultraviolet-B radiation.

Catharanthus roseus produces a large array of terpenoid indole alkaloids (TIAs) that are important natural source for many drugs. Ultraviolet B (UVB) radiation have been proved to have regulatory effect towards biosynthesis of TIAs, which were meaningful for boost of TIA production. To decipher more comprehensive molecular characteristics in C.

Research on vibration stability of a mirror bender system for synchrotron radiation.

This paper accurately predicts and quantifies the vibration response characteristics of a mirror bender system with the finite element simulation and experiment. The results show that the fundamental frequency of the roll angle vibration is 24.66 Hz, and the fundamental frequency of the pitch angle vibration is 116.

A Twindrive Precise Delivery System of Platelet-Neutrophil Hybrid Membrane Regulates Macrophage Combined with CD47 Blocking for Postoperative Immunotherapy.

During wound healing after cancer surgery, platelets, neutrophils, and macrophages accumulate at the wound site and induce important pathophysiological features. Utilizing these pathophysiological features, the development of targeted delivery systems for postoperative tumor immunotherapy is an important strategy. Herein, a twindrive precise delivery system of hybrid membrane combined with CD47 blocking is developed for targeted delivery and targeted regulation to induce postoperative immunotherapy.

An improved algorithm for thermal compensation of synchrotron radiation optical mirrors based on Hessian matrix.

The heaters-based thermal-compensated adaptive adjustment of a reflection mirror at Shanghai high repetition rate X-ray Free-Electron Laser and extreme light facility (SHINE) is presented here based on finite element analysis. The correction performance of different control algorithms [singular value decomposition and gradient descent (GD)] is analyzed and compared. This study has demonstrated that a significant control algorithm can further improve the surface shape accuracy of the mirror.

Exosomal miR-200c and miR-141 as cerebrospinal fluid biopsy biomarkers for the response to chemotherapy in primary central nervous system lymphoma.

Background: To improve early diagnosis and chemotherapy efficacy monitoring in primary central nervous system lymphoma (PCNSL), cerebrospinal fluid (CSF) exosomal microRNA (miRNA) studies were performed.

Method: Small RNA sequencing was performed to identify candidate exosomal miRNAs as CSF biopsy biomarkers from two patients with de novo PCNSL and two patients in remission after chemotherapy. miR-200c and miR-141 expression in CSF exosomes was further validated using relative quantitative real-time polymerase chain reaction in patients with PCNSL (n = 20), patients with other neurological diseases (n = 10), and normal subjects (n = 10).

Macrophages-Based Biohybrid Microrobots for Breast Cancer Photothermal Immunotherapy by Inducing Pyroptosis.

Pyroptosis-based immunotherapy can escape drug resistance as well as inhibit metastasis. It is urgently required to develop a delivery platform to induce targeted tumor-specific pyroptosis for cancer immunotherapy. Herein, macrophages-based biohybrid microrobots (IDN@MC) are constructed with IR-macrophage and decitabine-loaded Metal-organic frameworks (DZNPs).

Combined exposure to PM and PM in reductions of physiological development among preterm birth: a retrospective study from 2014 to 2017 in China.

Background: Preterm birth (PTB) has been linked with ambient particulate matter (PM) exposure. However, data are limited between physiological development of PTB and PM exposure.

Methods: Trimester and season-specific PM exposure including PM and PM was collected from Jiaxing between January 2014 and December 2017.

Identification of CD147-positive extracellular vesicles as novel non-invasive biomarkers for the diagnosis and prognosis of colorectal cancer.

Background: The mortality rate of colorectal cancer (CRC) can be decreased with effective screening and early diagnosis. Exosomes are released from cancer cells into the bloodstream, and circulating exosomes may serve as novel biomarkers. This study aimed to identify a sensitive and rapid method of exosome collection and measurement using specific antibodies.

Anti-bacterial mechanism of baicalin-tobramycin combination on carbapenem-resistant .

Background: () is an important cause of nosocomial infections, and contributes to high morbidity and mortality, especially in intensive care units. is considered a 'critical' category bacterial pathogen by the World Health Organization to encourage an urgent need for research and development of new antibiotics against its infections.

Aim: To investigate the effectiveness of baicalin combined with tobramycin therapy as a potential treatment method for carbapenem-resistant (CRPA) infections.

Fluidic MXene Electrode Functionalized with Iron Single Atoms for Selective Electrocatalytic Nitrate Transformation to Ammonia.

The growth of renewable energy industries and the ongoing need for fertilizer in agriculture have created a need for sustainable production of ammonia (NH) using low-cost, environment-friendly techniques. The electrocatalytic nitrate (NO) reduction reaction (NORR) has the potential to improve both the management of environmental nitrogen and the recycling of synthetic nutrients. However, NORR is frequently hindered by the incomplete NO conversion, sluggish reaction kinetics, and suppression of the hydrogen evolution reaction (HER).

A General Strategy to Synthesize Fluidic Single Atom Electrodes for Selective Reactive Oxygen Species Production.

Fine-tuning the geometric and electronic structure of catalytic metal centers via N-coordination engineering offers an effective design for the electrocatalytic transformation of O to singlet oxygen (O). Herein, we develop a general coordination modulation strategy to synthesize fluidic single-atom electrodes for selective electrocatalytic activation of O to O. Using a single Cr atom system as an example, >98% O selectivity can be achieved from electrocatalytic O activation due to the subtle engineering of Cr-N sites.

A Mini-Review on the Thermal Fatigue Properties of Copper Materials Applied at the Front-End of Synchrotron Radiation Facilities.

Oxygen-free high-conductivity copper (OFHC), chromium-zirconium copper (CuCrZr), and Glidcop AL-15 are widely used in the high heat load absorber elements at the front end of synchrotron radiation facilities. It is necessary to choose the most suitable material according to the actual engineering conditions (such as the specific heat load, material performance, and costs). In the long-term service period, the absorber elements have to bear hundreds or kilowatts of high heat load and its "load-unload" cyclic loading mode.

Occurrence and ecological risk assessment of 16 phthalates in surface water of the mainstream of the Yangtze River, China.

Phthalic acid esters (PAEs), a class of typical endocrine disruptors, have received considerable attention due to their widespread applications and adverse effects on biological health. In this study, 30 water samples, along the mainstream of the Yangtze River (YR), were collected from Chongqing (upper stream) to Shanghai (estuary) from May to June in 2019. The total concentrations of 16 targeted PAEs ranged from 0.

Neutrophil Camouflaged Stealth Nanovehicle for Photothermal-Induced Tumor Immunotherapy by Triggering Pyroptosis.

The regulation of tumor immunosuppressive microenvironments via precise drug delivery is a promising strategy for preventing tumor recurrence and metastasis. Inspired by the stealth strategy, a stealthy nanovehicle based on neutrophil camouflage is developed to achieve precise delivery and tumor immunotherapy by triggering pyroptosis. The nanovehicle comprises anti-CD11b- and IR820-conjugated bovine serum albumin nanoparticles loaded with decitabine.

Ephedrine vs. phenylephrine effect on sublingual microcirculation in elderly patients undergoing laparoscopic rectal cancer surgery.

Background: The effects of anesthesia administration on sublingual microcirculation are unknown. It is unclear how sublingual microcirculation responds to ephedrine or phenylephrine administration. We hypothesized that microvascular perfusion is impaired under anesthesia.

Mo Vacancy-Mediated Activation of Peroxymonosulfate for Ultrafast Micropollutant Removal Using an Electrified MXene Filter Functionalized with Fe Single Atoms.

Developing advanced heterogeneous catalysts with atomically dispersed active sites is an efficient strategy to boost the kinetics of peroxymonosulfate (PMS) activation for micropollutant removal. Here, we report a binary MoTiCT MXene-based electroactive filter system with abundant surface Mo vacancies for effective activation of PMS. The Mo vacancies assumed two essential roles: (i) as anchoring sites for Fe single atoms (Fe-SA) and (ii) as cocatalytic sites for the Fenton-like reaction.