[Water Transformation Relationship in Inner Mongolia Section of the Yellow River Basin Based on Stable Hydrogen and Oxygen Isotopes].

By collecting the atmospheric precipitation, surface water, and groundwater in the Inner Mongolia section of the Yellow River Basin in July 2021 （wet season）, October （normal season）, and April 2022 （dry season）, stable isotope technology was used to analyze the temporal and spatial changes in hydrogen and oxygen stable isotopes in the "three rivers" of the basin, and the MixSIAR mixing model was used to reveal the water body transformation relationship. The results showed that the mean difference in the groundwater isotope was small in the abundance period, flat period, and dry period in the Mongolia section of the Yellow River Basin. The groundwater regeneration was slow, the retention time was long, the seasonal variation was not obvious, and the D value of surface water was higher in the abundance period than in the normal period and dry period.

Hydrogeochemical evolution patterns of diverse water bodies in mining area driven by large-scale open-pit combined underground mining-taking Pingshuo Mining Area as an example.

Large-scale open-pit combined underground mining activities (OUM) not only reshape the original topography, geomorphology, and hydrogeochemical environment of the mining area, but also alter the regional water cycle conditions. However, due to the complexity arising from the coexistence of two coal mining technologies (open-pit and underground mining), the hydrological environmental effects remain unclear. Here, we selected the Pingshuo Mining Area in China, one of the most modernized open-pit combined underground mining regions, as the focus of our research.

[Effect of Plasma Epstein-Barr Virus Nucleic Acid Loads on the Clinical Features and Prognosis in Adult Secondary Hemophagocytic Lymphohistiocytosis].

Objective: To investigate the effect of pre-treatment plasma Epstein-Barr virus (EBV) DNA copy number on the clinical features and prognosis of patients with adult secondary hemophagocytic lymphohistiocytosis(sHLH).

Methods: The clinical characteristics, survival rate, and prognostic factors of 171 patients with adult sHLH treated at Jiangsu Province Hospital from June 2017 to January 2022 were retrospectively analyzed in this study. Patients were divided into three groups, including the EBV DNA-negative group(<5.

Resistance of grassland productivity to drought and heatwave over a temperate semi-arid climate zone.

Drought and heatwave are the primary climate extremes for vegetation productivity loss in the global temperate semi-arid grassland, challenging the ecosystem productivity stability in these areas. Previous studies have indicated a significant decline in the resistance of global grassland productivity to drought, but we still lack a systematic understanding of the mechanisms determining the spatiotemporal variations in grassland resistance to drought and heatwave. In this study, we focused on temperate semi-arid grasslands of China (TSGC) to assess the spatiotemporal variations of grassland productivity resistance to different climate extremes: compound dry-hot events, individual drought events, and individual heatwave events that occurred during 2000-2019.

Carbon flux dynamics and influencing factors in a semi-arid dune ecosystem of northern China.

The dune ecosystem plays a significant role in the global carbon cycle. The Horqin Sandy Land is a typical semi-arid fragile ecosystem in northern China. Understanding the magnitudes and dynamics of carbon dioxide fluxes within this region is essential for understanding the carbon balance.

Identifying the spatio-seasonal pattern of hydrochemical evolution and surface water-groundwater interaction in a large urban river basin, Northwest China.

There is insufficient understanding of the spatio-temporal evolution of surface water-groundwater quality and hydraulic connection under both natural and human influences in urban river basins. To this end, this paper investigated the spatio-seasonal pattern of hydrochemical evolution and surface water-groundwater interaction in a typical urban river basin (Dahei River basin) based on isotopic and hydrochemical data of 132 water samples collected during three seasons (normal, wet and dry seasons). From the normal season to the wet season, surface water in the Dahei River basin was dominated by the impacts of evaporation and groundwater discharge processes.

Spatial and temporal distribution characteristics and risk assessment of heavy metals in groundwater of Pingshuo mining area.

Groundwater pollution in the Pingshuo mining area is strongly associated with mining activities, with heavy metals (HMs) representing predominant pollutants. To obtain accurate information about the pollution status and health risks of groundwater, 189 groups of samples were collected from four types of groundwater, during three periods of the year, and analyzed for HMs. The results showed that the concentration of HMs in groundwater was higher near the open pit, waste slag pile, riverfront area, and human settlements.

The dynamic role of nucleoprotein SHCBP1 in the cancer cell cycle and its potential as a synergistic target for DNA-damaging agents in cancer therapy.

Background: Malignant tumours seriously threaten human life and health, and effective treatments for cancer are still being explored. The ability of SHC SH2 domain-binding protein 1 (SHCBP1) to induce cell cycle disturbance and inhibit tumour growth has been increasingly studied, but its dynamic role in the tumour cell cycle and corresponding effects leading to mitotic catastrophe and DNA damage have rarely been studied.

Results: In this paper, we found that the nucleoprotein SHCBP1 exhibits dynamic spatiotemporal expression during the tumour cell cycle, and SHCBP1 knockdown slowed cell cycle progression by inducing spindle disorder, as reflected by premature mitotic entry and multipolar spindle formation.

Comparison of different treatment regimens and analysis of prognostic factors in secondary hemophagocytic lymphohistiocytosis in adults: A single-center retrospective study.

Background: Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disease caused by immune hyperactivation. The overall survival (OS) of adults with secondary HLH remains suboptimal and new treatment strategies are needed.

Objectives: This study aimed to compare the efficacy of different regimens in the treatment of secondary HLH in adults and analyze the prognostic factors affecting patient survival.

Occurrence, source apportionment, and ecological risk of legacy and emerging per- and poly-fluoroalkyl substances (PFASs) in the Dahei river basin of a typical arid region in China.

Per- and poly-fluoroalkyl substances (PFASs) are artificial chemicals with broad commercial and industrial applications. Many studies about PFASs have been conducted in densely industrial and populated regions. However, fewer studies have focused on the PFASs' status in a typical arid region.

[Relationship Between Precipitation, River Water, and Groundwater Conversion in the Upper Reaches of Xilin River During the Rainy Season].

To deeply understand the hydrological cycle process and the transformation mechanism of different water bodies in the grassland inland river basin, the atmospheric precipitation, river water, and groundwater in the Xilin River Basin were taken as the research objects, the hydrogen and oxygen stable isotopes were analyzed, and the multi-scale spatio-temporal characteristics were analyzed to explore the quantitative transformation relationship between different water bodies in the basin. The results showed that:① the Xilin River Basin had an obvious inland semi-arid climate, the atmospheric precipitation was the main source of recharge for the river water and groundwater, and the groundwater and river water experienced different degrees of non-equilibrium evaporation at the same time. ② The isotopic composition of the river water showed the characteristics of depletion in spring and autumn and enrichment in summer and showed a trend of increasing from upstream to downstream in space.

Assessing long-term trends in vegetation cover change in the Xilin River Basin: Potential for monitoring grassland degradation and restoration.

Under the influence of climate change and human activities, the problem of grassland degradation is becoming increasingly severe. Detection of changes in vegetation cover is crucial for a better understanding of the interaction between humans and ecosystems. This study maps changes in vegetation cover using the Google Earth Engine (GEE).

Deciphering spatio-seasonal patterns, driving forces, and human health risks of nitrate and fluoride enriched water bodies in the Inner Mongolia Reaches of the Yellow River Basin, China.

The ecology and environment of the Yellow River Basin is threatened by fluoride and nitrate contamination induced by anthropogenic activity and geogenic factors. As a result, deciphering the spatio-temporal variability of fluoride and nitrate contamination in this area remains a challenge. Three hundred eighty-six samples of surface water and groundwater from the Inner Mongolia Reaches of the Yellow River Basin were taken for this investigation.

[Water Chemical Isotope Characteristics and Water Transformation Relationship in Mongolian Section of the Yellow River Basin].

The Yellow River in Inner Mongolia was selected as the study area in this study. In July (wet season) and October (dry season) of 2021, the acquisition of seasonal rivers, the Yellow River tributaries and precipitation, the Yellow River, Wuliangsuhai, Lake Hasuhai, Lake Daihai, an irrigation canal system, and underground water and sea water samples were collected to test the water chemical composition and hydrogen and oxygen isotopic values of different water types. Using the Piper triplot, Gibbs plot, ion ratio, and MixSIAR model methods, the evolution of water chemistry in the Mongolian section of the Yellow River Basin was analyzed, and the transformation relationship between precipitation, surface water, and groundwater was revealed.

Study on spatio-temporal simulation and prediction of regional deep soil moisture using machine learning.

Deep soil moisture (SM) plays a crucial role in vegetation restoration, particularly in semi-arid areas. However, current SM products have limited access and do not meet the spatio-temporal scale and soil depth requirements in eco-hydrological research. Thus, this study constructs a random forest prediction model for SM at different depths by identifying driving factors and quantifying the correlation effect of vertical SM based on the international SM network dataset.

Large-scale surface water-groundwater origins and connectivity in the Ordos Basin, China: Insight from hydrogen and oxygen isotopes.

The sustainability of water resources is a major challenge for the Ordos Basin and Loess Plateau of China. The basis of effective water management is an understanding of the water cycle process. This study investigated the surface water-groundwater origins and connectivity using stable isotopes (δD and δO) of surface water and groundwater in 11 river basins in the Ordos Basin.

Clinical value of soluble fms-like tyrosine kinase 1 (sFlt-1) in adult secondary hemophagocytic lymphohistiocytosis.

Background: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a syndrome characterized by an excessive systemic inflammatory response, manifested by multiple organ dysfunction, lacking reliable immune biomarkers for predicting their inflammatory status and prognosis. Soluble fms-like tyrosine kinase 1 (sFlt-1) is associated with various inflammation-related diseases, including sepsis and severe organ failure.

Methods: This study retrospectively included 32 adult sHLH patients diagnosed from January 2020 to December 2021.

Prognostic value of the albumin-bilirubin score in patients with non-Hodgkin lymphoma-associated hemophagocytic lymphohistiocytosis.

Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare life-threatening systemic disease. This study aimed to assess the prognostic value of pretreatment albumin-bilirubin (ALBI). We retrospectively analyzed 168 non-Hodgkin lymphoma-associated secondary hemophagocytic lymphohistiocytosis (NHL-sHLH) patients with hepatic injuries.

Genome-Wide Splicing Quantitative Expression Locus Analysis Identifies Causal Risk Variants for Non-Small Cell Lung Cancer.

Unlabelled: Alternative RNA splicing is an essential mechanism linking genetic variation to human diseases. While the signals from genome-wide association studies (GWAS) have been linked to expression quantitative trait loci (eQTL) in previous studies, further work is needed to better elucidate the relationship to other genetic regulatory mechanisms, such as splicing QTLs (sQTL). Here, we performed a genome-wide sQTL analysis to identify variants that might affect RNA splicing in 1,010 non-small cell lung cancer (NSCLC) samples from The Cancer Genome Atlas.

Prognostic value of lipid profile in adult hemophagocytic lymphohistiocytosis.

Background: Adult secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare clinical syndrome with a high mortality rate. Currently, there are no feasible prognostic factors to clinically predict untreated sHLH patients' prognosis. Our objective was to characterize the lipid profile of adult sHLH patients and to determine the relationship with overall survival.

Employment intentions among rural order-oriented medical students in inner mongolia autonomous region, China.

Background: The program of the "Free Training of Chinese Rural Order-Oriented Medical Students" is a plan to train general practitioners who can work at rural medical institutions. However, many students have been unwilling to fulfill their commitments and actually work in their assigned locations.

Objective: This study aimed to provide some explanation by exploring factors influencing the employment intentions of rural order-oriented medical students in Inner Mongolia Autonomous Region of China to provide a basis for formulating relevant supporting policies to help increase the fulfillment rate of medical students.

Nanopore membrane chip-based isolation method for metabolomic analysis of plasma small extracellular vesicles from COVID-19 survivors.

Multiple studies showed that metabolic disorders play a critical role in respiratory infectious diseases, including COVID-19. Metabolites contained in small extracellular vesicles (sEVs) are different from those in plasma at the acute stage, while the metabolic features of plasma sEVs of COVID-19 survivors remain unknown. Here, we used a nanopore membrane-based microfluidic chip for plasma sEVs separation, termed ExoSEC, and compared the sEVs obtained by UC, REG, and ExoSEC in terms the time, cost, purity, and metabolic features.