Nicotinate-Modified Lanthanide-Substituted Selenotungstate and Its Catalase-like Activity for the Detection of HO and Ascorbic Acid.

A rigid nicotinate-modified lanthanide-substituted selenotungstate [HN(CH)]NaH[LaSeW(HO)(nica)O][SeWO]·32HO (, Hnica = nicotinic acid) was synthesized and consists of two trivacant Keggin [B-α-SeWO] fragments and one unusual [SeWO] fragment bridged by a heterometallic [LaW(HO)(nica)O] cluster. In the heterometallic cluster, two carboxyl O atoms in two nicotinate ligands directly coordinate with two W atoms in a stable C-O-W-O-W-O six-membered ring fashion. According to its catalase-like activity, was utilized to catalyze the oxidation of 3,3',5,5'-tetramethylbenzidine (TMB) by HO to produce blue oxidized TMB (ox-TMB), which can be used to establish a colorimetric sensing method for the detection of ascorbic acid.

Combination of carrageenan with sodium alginate, gum arabic, and locust bean gum: Effects on rheological properties and quiescent stabilities of partially crystalline emulsions.

In the present study, carrageenan (CG) was combined with sodium alginate (SA), gum arabic (GA), and locust bean gum (LBG) to obtain four gum combinations (CG, CG + SA, CG + GA, and CG + LBG). The effects of different combinations on rheological properties and quiescent stabilities of PCEs were systematically investigated through characterization of fresh emulsion related parameters (rheological properties, forces between proteins, zeta potentials, surface tensions, interfacial adsorption properties, and multiple light scattering) and storage related parameters (visual appearance, creaming index, viscosities, particle sizes, and microscopic morphology). Rheological results indicated that CG PCEs had the highest apparent viscosities of 7.

Dietary Supplementation with Different Types of Potassium and Magnesium during Late Gestation and Lactation Modulates the Reproductive Performance, Antioxidant Capacity, and Immune Function of Sows.

The objective of this study was to investigate the effects of dietary supplementation with different types of potassium and magnesium on the reproductive performance, antioxidant capacity, and immunity of sows. Forty-five Landrace × Yorkshire sows at the late gestation stage (85 d) were randomly assigned to three groups (n = 15). Sows in the control group (CON), potassium chloride and magnesium sulfate group (PM), and potassium-magnesium sulfate group (PMS) were fed with a basal diet, a basal diet supplemented with magnesium sulfate (0.

Analysis of 17 Prenatal Cases with the Chromosomal 1q21.1 Copy Number Variation.

Copy number variations (CNVs) at the chromosomal 1q21.1 region represent a group of hot-spot recurrent rearrangements in human genome, which have been detected in hundreds of patients with variable clinical manifestations. Yet, report of such CNVs in prenatal scenario was relatively scattered.

Whole exome sequencing identified a novel compound heterozygous variation in COL7A1 gene causing dystrophic epidermolysis bullosa.

Dystrophic epidermolysis bullosa (DEB) is a series of severe genetic conditions affecting skin and nails caused by mutations in the COL7A1 gene. DEB has a strong phenotypic variability. In the present study, we recruited a case with a boy exhibiting typical DEB indication, and performed a clinical, genetic, and experimental investigation, followed by a prenatal diagnosis on their current pregnancy.

Double Trigonal Pyramidal {SeO} Groups Bridged 2-Picolinic Acid Modified Cerium-Inlaid Polyoxometalate Including Mixed Selenotungstate Subunits for Electrochemically Sensing Ochratoxin A.

An organic-inorganic hybrid trigonal pyramidal {SeO} group, bridged cerium-inlaid polyoxometalate (POM) Na[SeCe(HO)W(HPIC)O][B-β-SeWO][SeWO]·60HO () (HPIC = 2-picolinic acid), containing two disparate selenotungstate (ST) building blocks was synthesized by a one-step assembly strategy, which is established by two asymmetric sandwich-type {[Ce(HO)W(HPIC)O][B-β-SeWO][SeWO]} moieties joined by double trigonal pyramidal {SeO} groups. Its outstanding structural trait is that it contains two types of ST building blocks, Keggin-type [B-β-SeWO] and Dawson-like [SeWO], which are extremely rare in ST chemistry. Remarkably, [SeWO] is first obtained in lanthanide-inlaid STs.

Whole Exome Sequencing Facilitated the Identification of a Mosaic Small Supernumerary Marker Chromosome (sSMC).

Small supernumerary marker chromosomes (sSMCs) are a group of rare chromosomal anomalies, which pose challenges in the clinical practice of prenatal diagnosis and genetic counseling. This study enrolled an extended family with an underage male patient displaying infantile seizures, intellectual disability, and retarded speech and psychomotor function. A series of multiplatform genetic detections was conducted to explore the diagnostic variation.

Adaptive Neural Network Control for a Class of Fractional-Order Nonstrict-Feedback Nonlinear Systems With Full-State Constraints and Input Saturation.

This article addresses an adaptive neural network (NN) constraint control scheme for a class of fractional-order uncertain nonlinear nonstrict-feedback systems with full-state constraints and input saturation. The radial basis function (RBF) NNs are used to deal with the algebraic loop problem from the nonstrict-feedback formation based on the approximation structure. In order to overcome the problem of input saturation nonlinearity, a smooth nonaffine function is applied to approach the saturation function.

Tracking control of state constrained fractional order nonlinear systems.

This article investigates adaptive output-feedback control problems for full-state constrained fractional order uncertain strict-feedback systems with unmeasured states and input saturation. By considering the structure of the systems, a fractional order observer is framed to estimate unmeasurable states. By using the backstepping procedure and barrier Lyapunov function, the adaptive controller with adaptation laws are proposed in each step.

Multiple antibiotics distribution in drinking water and their co-adsorption behaviors by different size fractions of natural particles.

In recent years, natural particles in drinking water have attracted attention due to their carry of toxic organic matter. However, the adsorption behavior of multiple antibiotics at very low concentrations on different sized particles has not been revealed. Here, the content of 17 antibiotics in water samples collected from four process stages of the water supply plant was detected.

Cotransport and deposition of colloidal polystyrene microplastic particles and tetracycline in porous media: The impact of ionic strength and cationic types.

The cotransport behaviors of colloidal polystyrene microplastic particles (PSMPs) and tetracycline (TC) (20 mg/L) were investigated in saturated porous media in KCl and CaCl solutions of various ionic strengths (1, 10, 50, 100 mM). Furthermore, the effects of TC concentration (0, 1, 5, 10, 20 mg/L) on the cotransport behaviors of PSMPs and TC in 100 mM KCl solution were assessed. The cotransport behaviors were analyzed by comparing the individual transport behaviors of PSMPs or TC.

Multidisciplinary respiratory rehabilitation in combination with non-invasive positive pressure ventilation in the treatment of elderly patients with severe chronic obstructive pulmonary disease.

Objective: To explore the effectiveness of multidisciplinary comprehensive respiratory rehabilitation in combination with non-invasive positive pressure ventilation (NIPPV) in the treatment of elderly patients with severe chronic obstructive pulmonary disease (COPD).

Methods: Eighty-eight elderly patients with severe COPD who were admitted by the hospital between February 2016 and April 2017 were enrolled and grouped into a control group (n=29), intervention Group-A (n=30) and intervention Group-B (n=29) according to random sampling. Patients in the control group were given medicines and oxygen therapy; intervention Group-A was given NIPVV in addition to medicines and oxygen therapy; intervention Group-B was given multidisciplinary comprehensive respiratory rehabilitation in addition to the treatment as the intervention Group-A.

Intermittent injection of Methylprednisolone Sodium Succinate in the treatment of Cervical Spinal Cord injury complicated with incomplete paraplegia.

Objective: To evaluate the clinical efficacy and safety of intermittent injection of methylprednisolone sodium succinate in the treatment of cervical spinal cord injury complicated with incomplete paraplegia.

Methods: Seventy-eight patients with cervical spinal cord injury complicated with incomplete paraplegia who were admitted between August 2016 and December 2017 were enrolled and grouped into an observation group and a control group using random number table, 39 in each group. Patients in the control group were given vertebral body decompression and bone grafting and internal fixation according to the severity of spinal cord compression, while patients in the observation group were treated by methylprednisolone sodium succinate in addition to the same treatment as the control group.

Controlled blood pressure elevation and limited fluid resuscitation in the treatment of multiple injuries in combination with shock.

Objective: To explore the effectiveness of controlled blood pressure elevation and limited fluid resuscitation in treating patients with multiple injuries in combination with shock in Intensive Care Unit (ICU).

Methods: One hundred and sixty-four patients with multiple injuries in combination with shock who were admitted into the ICU of the hospital between June 2014 and November 2017 were selected and divided into an observation group and a control group using random number table, 82 each group. Controlled blood pressure elevation was given to both groups.

Influence of psychological intervention on pain and immune functions of patients receiving lung cancer surgery.

Objective: To observe the influence of psychological intervention on pain, immune system and adrenocortical functions of patients receiving lung cancer surgery.

Methods: We selected 124 patients who received surgery for treating stage I or II lung cancer and divided into experimental group and control group. The experimental group received comprehensive psychological intervention while the control group was given conventional nursing intervention.

Protein expression under sustained activation of signal transducer and activator of transcription-3 in diethylnitrosamine-induced rat liver carcinogenesis.

The aim of the present study was to investigate the expression of proteins associated with the sustained activation of the signal transducer and activator of transcription (STAT)-3 pathway during diethylnitrosamine (DEN)-induced rat liver carcinogenesis. DEN was intermittently administered to rats to induce liver cancer, and light and electron microscopy were used to observe the morphological changes in the liver during carcinogenesis. Western blotting and quantitative polymerase chain reaction (qPCR) were used to detect the expression of STAT-3, phosphorylated (p)-STAT-3, matrix metalloproteinase (MMP)-10, vascular endothelial growth factor (VEGF), kinase insert domain receptor (KDR), hypoxia inducible factor (HIF)-1α, basic fibroblast growth factor (bFGF) and interleukin (IL)-10, in order to investigate the association between STAT-3 and p-STAT-3 expression and MMP-10, VEGF, KDR, HIF-1α, bFGF and IL-10.

Endoplasmic reticulum stress in diethylnitrosamine-induced rat liver cancer.

To analyze the significance of endoplasmic reticulum stress (ERS) in the development of diethylnitrosamine (DEN)-induced liver cancer in rats, critical regulatory factors in ERS signaling pathways were investigated in the present study. The results showed that the expression of ERS-related proteins gradually increased in the early and mid-term stages of carcinogenesis, while in the later stages, the expression of these proteins did not change significantly after reaching a peak. ERS is involved in DEN-induced rat liver injury, the proliferation of liver cells and the occurrence and development of liver cirrhosis.

In-vacuum projection of nanoparticles for on-chip tunneling spectroscopy.

Starting with a discussion of the percolation problem applied to the trapping of conducting nanoparticles between nanometer-spaced electrodes, we show that a good strategy to trap a single nanoparticle between the electrodes is to prepare chips with low coverage of nanoparticles to avoid percolating current paths. To increase the probability of trapping a single nanoparticle, we developed a new method where nanoparticles are projected in-vacuum on the chip, followed by a measure of the tunnel current, in a cycle that is repeated up to a few thousand times until a preset threshold value is reached. A plot of the tunneling current as a function of time allows discriminating between the two possible current paths, i.

Inhibition of tumor angiogenesis by TTF1 from extract of herbal medicine.

Aim: To study the inhibition of tumor angiogenesis by 5,2,4´-trihydroxy-6,7,5´-trimethoxyflavone (TTF1) isolated from an extract of herbal medicine Sorbaria sorbifolia.

Methods: Angiogenic activity was assayed using the chick embryo chorioallantoic membrane (CAM) method. Microvessel density (MVD) was determined by staining tissue sections immunohistochemically for CD34 using the Weidner capillary counting method.