Publications by authors named "Limiao Si"
Article Synopsis
- Progerin, a mutated protein, causes severe nuclear abnormalities in patients with Hutchinson-Gilford progeria syndrome (HGPS), which is a condition that leads to premature aging.
- The research shows that problems with the IGF-1R/Akt signaling pathway in a mouse model contribute to growth issues and accelerated aging due to progerin's mislocalization and negative impact on mitochondrial function.
- Treatment with a specific drug boosts Akt activity and helps alleviate multiple symptoms in progeroid mice, suggesting potential therapeutic approaches for related aging disorders.
