Publications by authors named "Limiao Si"

Article Synopsis
  • Progerin, a mutated protein, causes severe nuclear abnormalities in patients with Hutchinson-Gilford progeria syndrome (HGPS), which is a condition that leads to premature aging.
  • The research shows that problems with the IGF-1R/Akt signaling pathway in a mouse model contribute to growth issues and accelerated aging due to progerin's mislocalization and negative impact on mitochondrial function.
  • Treatment with a specific drug boosts Akt activity and helps alleviate multiple symptoms in progeroid mice, suggesting potential therapeutic approaches for related aging disorders.
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