Publications by authors named "Limian Lin"

Dry eye disease (DED) is a multifactorial disease with an incidence of approximately 50% worldwide. DED seriously affects quality of life and work. The prevalence of environmental DED (eDED) ranges from 35 to 48%.

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Importance: Evaluating corneal morphologic characteristics with corneal tomographic scans before refractive surgery is necessary to exclude patients with at-risk corneas and keratoconus. In previous studies, researchers performed screening with machine learning methods based on specific corneal parameters. To date, a deep learning algorithm has not been used in combination with corneal tomographic scans.

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Purpose: To evaluate the outcomes of 4 low laser energy levels after small-incision lenticule extraction (SMILE) surgery.

Setting: Zhongshan Ophthalmic Center, Guangzhou, China.

Design: Prospective randomized clinical trial.

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Purpose: To compare the effect of two scanning modes with different femtosecond laser settings on clinical outcomes and ultrastructural analysis of the lenticule surface in small incision lenticule extraction (SMILE).

Methods: A total of 78 eyes from 39 consecutive patients were included with the standard scanning mode (energy level of 105 nJ vs spot distance of 3 mm) in one eye and the fast scanning mode (energy level of 110 nJ vs spot distance of 4.5 mm) in the other eye, all eyes being randomly assigned.

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The advent of "flapless" small-incision lenticule extraction (SMILE), employing all-in-one technology, has resulted in a revolutionary breakthrough in refractive surgeries. SMILE has been gaining popularity due to fewer potential complications, such as postoperative dry eyes and greater biomechanical stability, etc. However, attention must be given to 1) the centration on the corneal vertex, 2) the proper alignment of the astigmatic axis, and 3) the relationship between pupil size and treatment diameter, to achieve good SMILE results.

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Purpose: To comparatively investigate the clinical outcomes of small incision lenticule extraction (SMILE) surgery with or without cyclotorsion compensation for the correction of myopic astigmatism.

Methods: This prospective, double-blinded, randomized controlled trial included patients who underwent SMILE surgery with bilateral myopic astigmatism. Two eyes of a single patient were randomly divided into the static cyclotorsion compensation (SCC) group and the control group.

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Purpose: To investigate the effects and mechanisms of fasudil hydrochloride (fasudil) on and in alkali burn-induced corneal neovascularization (CNV) in mice.

Methods: To observe the effect of fasudil, mice with alkali-burned corneas were treated with either fasudil eye drops or phosphate-buffered saline (PBS) four times per day for 14 consecutive days. After injury, CNV and corneal epithelial defects were measured.

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