Association between urinary metal concentrations and hyperuricemia in Chinese community-dwelling elderly: Exploring the mediating role of estimating glomerular filtration rate.

Background: It has been shown that multiple metals exposure is associated with hyperuricemia. However, previous studies on the association and interaction between multiple metals exposure and hyperuricemia have been controversial, and there has been little evaluation of the potential mediating role of estimating glomerular filtration rate (eGFR).

Methods: In this study, levels of 12 metals in the urine of 3756 study participants were measured using Inductively Coupled Plasma Mass Spectrometry (ICP-MS).