RNA-binding proteins potentially regulate the alternative splicing of apoptotic genes during knee osteoarthritis progression.

Background: Alternative splicing (AS) is a principal mode of genetic regulation and one of the most widely used mechanisms to generate structurally and functionally distinct mRNA and protein variants. Dysregulation of AS may result in aberrant transcription and protein products, leading to the emergence of human diseases. Although considered important for regulating gene expression, genome-wide AS dysregulation, underlying mechanisms, and clinical relevance in knee osteoarthritis (OA) remain unelucidated.

Prediction of hydrological and water quality data based on granular-ball rough set and k-nearest neighbor analysis.

Hydrological and water quality datasets usually encompass a large number of characteristic variables, but not all of these significantly influence analytical outcomes. Therefore, by wisely selecting feature variables with rich information content and removing redundant features, it not only can the analysis efficiency be improved, but the model complexity can also be simplified. This paper considers introducing the granular-ball rough set algorithm for feature variable selection and combining it with the k-nearest neighbor method and back propagation network to analyze hydrological and water quality data, thus promoting overall and fused inspection.

Sodium Alginate Aerogel as a Carrier of Organogelators for Effective Oil Spill Solidification and Recovery.

Marine oil spills pose a serious threat to the marine ecological environment. Phase-selective organogelators (PSOGs) are ideal candidates for oil spill gelation when used in combination with a mechanical recovery method. However, the toxicity of an organic solvent carrier has become a key problem when it is applied in the remediation of marine oil pollution.

Genome-wide expression analysis of genes in tomato ( L.) under different light conditions.

Lateral organ boundaries (LOB) domain () genes, a gene family that encodes the transcription factors (TFs) of plants, plays crucial functions in the development and growth of plants. Currently, genome-wide studies of the family are still limited to tomato ( L.), which is considered an important economic crop.

Analyzing Morphology, Metabolomics, and Transcriptomics Offers Invaluable Insights into the Mechanisms of Pigment Accumulation in the Diverse-Colored Labellum Tissues of .

plants are widely cherished for their vibrant and captivating flowers. The unique feature of this genus lies in their labellum, a specialized floral structure resulting from the fusion of two non-fertile staminodes. However, the intricate process of pigment formation, leading to distinct color patterns in the various labellum segments of , remains a subject of limited understanding.

Coupling Carbon-Based Composite Phase Change Materials with a Polyurethane Sponge for Sustained and Efficient Solar-Driven Cleanup of Viscous Crude Oil Spill.

The efficient cleanup of crude oil spills is a worldwide problem due to their high viscosity and low fluidity. Under the assistance of solar radiation, adsorbents with heating function are becoming the ideal candidates to solve this problem. In this study, a new strategy coupling a polyurethane (PU) sponge with phase change materials (PCMs) is proposed to realize the efficient utilization of solar energy and crude oil cleanup.

Three new furanones from endophytic fungus DYR-1-7 from with their antifungal activity.

DYR-1-7 is a endophytic fungus isolated from the Presl and has an inhibitory effect on . Three new furanones, hypoxylonone A-C (-), as well as three known compounds (-), were isolated from an EtOAc extract of DYR-1-7. The structures were determined by spectroscopic data analysis using UV, IR, 1D-, 2D-NMR and HR-ESI-MS.

Germacrane Sesquiterpene Dilactones from and Their Antibacterial and Cytotoxic Activity.

Four new germacrane sesquiterpene dilactones, 2-hydroxyl-11,13-dihydrodeoxymikanolide (), 3-hydroxyl-11,13-dihydrodeoxymikanolide (), 1,3-dihydroxy-4,9-germacradiene-12,8:15,6-diolide (), and (11,13-dihydrodeoxymikanolide-13-yl)-adenine (), together with five known ones (-) were isolated from the aerial parts of . Their structures were elucidated on the basis of extensive spectroscopic analysis. Compound is featured with an adenine moiety in the molecule, which is the first nitrogen-containing sesquiterpenoid so far isolated from this plant species.

Mesoporous carbon hollow spheres encapsulated phase change material for efficient emulsification of high-viscosity oil.

Low fluidity of high-viscosity oil usually hinders its emulsification. Facing this dilemma, we proposed a novel functional composite phase change material (PCM) with in situ heating feature coupled with emulsification capability. This composite PCM consisting of mesoporous carbon hollow spheres (MCHS) and polyethylene glycol (PEG) shows excellent photothermal conversion ability, thermal conductivity and Pickering emulsification.

Multi-energies assisted and all-weather recovery of crude oil by superhydrophobic melamine sponge.

Efficient and safe recovery of high-viscosity marine crude oil spills is still a worldwide challenge. High-viscosity crude oil is difficult to be removed by traditional adsorbent materials. Although some recent developments in photothermal or electric-thermal oil-absorbing materials, the vertical heat transfer inside and the potential hazard of electrical leakage are difficult to be guaranteed.

Efficacy of administrative intervention for neurosurgical patients with off-label use of alprostadil lipid microsphere.

As an adjuvant drug, alprostadil lipid microsphere injection (Lipo-PGE) is one of the best-selling drugs in China in recent years. However, the off-label use of Lipo-PGE is very common. This study aimed to investigate the use of Lipo-PGE and evaluate the clinical effects and economic benefits after administrative intervention on inappropriate use of Lipo-PGE in neurosurgical patients in a Chinese tertiary hospital.

α-Glucosidase inhibitors from brown rice bound phenolics extracts (BRBPE): Identification and mechanism.

Brown rice bound phenolics extracts (BRBPE) have been reported to possess α-glucosidase inhibitory effects, the specific enzyme inhibitors involved in this process were unknown. Here, α-glucosidase inhibitors in BRBPE were screened using bioaffinity ultrafiltration methods, and seven phenolic compounds - three monomers (p-coumaric acid, ferulic acid and methyl ferulate), three dimers (8-5', 5-5' and 8-O-4' diferulic acid) and a trimer (5-5'/8-O-4″ dehydrotriferulic acid) were identified as exact inhibitors, among which 5-5'/8-O-4″ dehydrotriferulic acid and 5-5'diferulic acid exhibited the best inhibitory activity. Enzyme kinetic analysis suggested that the inhibitory mechanism of these seven inhibitors including competitive, noncompetitive, uncompetitive and mixed manner.

Deep remediation of oil spill based on the dispersion and photocatalytic degradation of biosurfactant-modified TiO.

The employment of dispersant was an effective method to treat marine oil spill pollution. However, conventional dispersants only showed a single oil dispersion. Here, by modifying TiO nanoparticles with biosurfactant-Rhamnolipids (Rha), a highly efficient particulate dispersant with photocatalytic activity was developed.

Thymol derivatives with antibacterial and cytotoxic activity from the aerial parts of .

Three new thymol derivatives, 7-formyl-9-isobutyryloxy-8-hydroxythymol (1), 7,9-di-isobutyryloxy-8,10-dehydrothymol (2) and 2α-methoxyl-3β-methyl-6-methylol-2,3-dihydrobenzofuran (3), along with five known ones (4-8), were isolated from the aerial parts of the invasive plant . Their structures were elucidated by extensive spectroscopic analysis and they were all isolated from the aerial part of for the first time. These compounds, except 8, selectively showed antimicrobial activity against three Gram-(+) and two Gram-(-) bacterial strains.

Efficacy and Safety of Different Doses of Systemic Corticosteroids in COPD Exacerbation.

Background: Although systemic corticosteroids (SCS) have long been used to treat patients with COPD exacerbation, the recommended dose remains controversial. We aimed to perform a meta-analysis and an indirect treatment comparison to investigate the efficacy and safety of different doses of SCS in subjects with COPD exacerbation.

Methods: Studies were identified by searching different databases for randomized controlled trials that investigated the efficacy and safety of SCS with placebo in subjects with exacerbation of COPD.

Biodiversity and antifouling activity of fungi associated with two soft corals from the South China Sea.

Bacteria in corals have been studied in detail in the past decades. However, the biodiversity and bioactivity of fungi in corals are still poorly understood. This study investigated the biodiversity and antifouling activity of fungi in soft corals Cladiella krempfi and Sarcophyton tortuosum from the South China Sea.

Triterpenoids with α-glucosidase inhibitory activity and cytotoxic activity from the leaves of .

Ten pentacyclic triterpenoids including a new multiflorane triterpene acid, 2α,3β,23-trihydroxymultiflor-7-en-28-oic acid (1), and a new lupane triterpene monoglucoside named akebiaoside C (2), were obtained from the leaves of . Their structures were elucidated by extensive spectroscopic analysis, and they were all isolated from the leaves of for the first time. These compounds, except 4 and 5, showed α-glucosidase inhibitory activity much stronger than acarbose.

Anti-MRSA Sesquiterpenes from the Semi-Mangrove Plant A. Gray.

The striking rise of methicillin-resistant (MRSA) infections has become a serious threat to public health worldwide. In an effort to search for new anti-MRSA agents from natural products, a bioassay-guided phytochemical study was conducted on the semi-mangrove plant A. Gray, which led to the isolation of two new sesquiterpene alkaloids ( and ) and six known furanosesquiterpenes (⁻).

Characterization and immunological activity of polysaccharides from Ixeris polycephala.

A water-soluble polysaccharide, named KMCP, was isolated and purified from edible plant Ixeris polycephala by using DEAE-52 cellulose chromatography. Its structure was determined by chemical analysis, methylation analysis, and NMR analysis, coupled with characterization by scanning electron spectroscopy (SEM). The resulting data indicated that KMCP was an arabinogalactan, with an average molecular weight of 1.

Phenolics from Mikania micrantha and Their Antioxidant Activity.

A phytochemical study on the aerial parts of led to the isolation of two new phenolic compounds, benzyl 5--β-d-glucopyranosyl-2,5-dihydroxybenzoate () and (7,8)--dihydroxydehydrodiconiferyl alcohol 9-acetate (), together with twelve known compounds, benzyl 2--β-d-glucopyranosyl-2,6-dihydroxybenzoate (), 4-allyl-2,6-dimethoxyphenol glucoside (), (+)-isolariciresinol (), icariol A₂ (), 9,10-dihydroxythymol (), 8,9,10-trihydroxythymol (), caffeic acid (), -coumaric acid (), ethyl protocatechuate (), procatechuic aldehyde (), 4-hydroxybenzoic acid (), and hydroquinone (). Their structures were elucidated on the basis of extensive spectroscopic analysis. Except and , all the other compounds were isolated from this plant species for the first time.

Two New Thymol Derivatives from the Roots of Ageratina adenophora.

Two new thymol derivatives, 7,9-diisobutyryloxy-8-ethoxythymol () and 7-acetoxy-8-methoxy-9-isobutyryloxythymol (), were isolated from fresh roots of , together with four known compounds, 7,9-di-isobutyryloxy-8-methoxythymol (), 9-oxoageraphorone (), (-)-isochaminic acid () and (1α,6α)-10-hydroxycar-3-ene-2-one (). Their structures were established on the basis of detailed spectroscopic analysis, and they were all isolated from the roots of for the first time. All the compounds were tested for their in vitro antibacterial activity toward three Gram-positive and two Gram-negative bacterial strains.

Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata.

Two new pentacyclic triterpene saponins, named akebiaoside K (1) and akebiaoside N (2), were isolated from the leaves of Akebia trifoliata, together with five known triterpenoids 3-7. They were all isolated from the leaves of A. trifoliata for the first time.

[Chemical Constituents from Sphagneticola trilobata].

Objective: To study the chemical constituents of the whole plant of Sphagneticola trilobata.

Methods: The compounds were isolated and purified by column chromatography and their structures were determined by spectroscopic techniques.

Results: Three lignans, two indolics and two phenolic glycosides were isolated from the whole plant of Sphagneticola trilobata and identified as syringaresinol-4-O-β-D-glucopyranoside(1), pinoresinol-4-sulfate(2), pinoresinol-4-O-β-D-glucopyranoside(3), 1H-indole-3-carboxylic acid (4), 1H-indole-3-carbaldehyde(5), 2,6-dimethoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside (6), and 3,5-dimethoxy-4-hydroxyphenol-1-O-β-D-glucopyranoside (7).

[Minimally invasive treatment for fresh acromioclavicular dislocation and the distal clavicle fracture].

Objective: To explore the minimally invasive treatment for fresh acromioclavicular dislocation and the distal clavicle fracture.

Methods: Thirty skeletons of human shoulder were measured and compared, and the normal data on healthy people were measured with the help of ultrasound-guided. So the invasion point was located at the cross between subclavian axis and the line from coracoid tip to apophysis behind cone ligament node.