Publications by authors named "Limei Ao"
Article Synopsis
- Rheumatoid arthritis (RA) is an autoimmune disease leading to joint inflammation and damage, with growing interest in ferroptosis—a novel cell death mechanism—as a factor in RA.
- Ferroptosis influences synovial cells, chondrocytes, and immune cells, presenting potential pathways for therapeutic targets including inhibitors and activators.
- Despite its promise, the dual role and safety of ferroptosis in RA treatment remain under investigation, highlighting the need for further research on its mechanisms and development of safer treatments.
Matrine (Mat) is an alkaloid of tetracycline quinazine, and previous studies have demonstrated its specific effect on relieving rheumatoid arthritis (RA). However, the effect of Mat on joint synovial angiogenesis in the pathogenesis of RA has not been elucidated. In this study, body weight, joint swelling, arthritis index (AI) score, histopathological changes, immunohistochemical, and western blot- were used in collagen-induced arthritis (CIA) rats to detect pro-inflammatory factors and, - expression levels of key cytokines and proteins along the hypoxia-inducible factor (HIF)-endothelial growth factor (VEGF)-angiopoietin (Ang) axis and VEGF-phosphoinositide 3-kinase (PI3K) / protein kinase B (Akt) pathway.
View Article and Find Full Text PDFA unique, sensitive, and highly specific fluoroimmunoassay system for antigen detection using gold and magnetic nanoparticles has been developed. The assay is based on the fluorescence quenching of fluorescein isothiocyanate caused by gold nanoparticles coated with monoclonal antibody. To demonstrate its analytical capabilities, the magnetic nanoparticles were coated with anti-alpha-fetoprotein polyclonal antibodies, which specifically bound with alpha-fetoprotein.
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