Lucerne milestone approach for benchmarking and education: Towards ultra-low dose endovascular aortic repair.

Objective: The aim of this single-center case series is to demonstrate that an ultra-low dose (ULD) can be routinely achieved in the hybrid operating room in standard endovascular aortic repair (EVAR) for infrarenal abdominal aortic aneurysm by adjusting the manufacturer's predefined imaging parameters, hardware configurations and user protocols (including benchmarking).

Methods: The hybrid operating room manufacturer predefined EVAR software setup of the dose exposure control software (OPTIQ, Siemens Healthineers, Forchheim, Germany) at our university medical center was screened for possible improvements regarding radiation dose application. Tests on a water-equivalent as well as polymethyl methacrylate phantom model to assess the impact of technical settings were performed, including comparison of settings for exposure control software, different magnification, collimation configurations and detector distance.

Deletion of and genes in serovars induces a comparable immune response to wild-type infection in different chicken lineages.

It was previously reported that utilization of tetrathionate and 1,2-propanediol by spp. through the metabolic pathways encoded by and operons are related to overgrowth and out-competing microbiota in an anaerobic environment. However, recent knowledge demonstrated which strains in the absence of and genes provoke both higher intestinal colonization and spreading bacteria on faeces in relation to their respective wild-type strain, and generate more prominent inflammation as well.

Relationship of skeletal muscle mass, length of sports experience, and sexual maturity with bone density and geometry in adolescent athletes.

Objective: To identify the relationship between length of sports experience, muscle mass, and sexual maturity with bone mineral density (BMD) and geometry in adolescent basketball and track and field athletes.

Method: The study included adolescent (11-18 years) athletes, of both sexes, who practiced basketball (n = 26) or track and field (n = 24). Skeletal muscle mass was measured by bioelectrical impedance analysis.

Safe and Orally Bioavailable Inhibitor of Serine Palmitoyltransferase Improves Age-Related Sarcopenia.

The accumulation of ceramides and related metabolites has emerged as a pivotal mechanism contributing to the onset of age-related diseases. However, small molecule inhibitors targeting the ceramide synthesis pathway for clinical use are currently unavailable. We synthesized a safe and orally bioavailable inhibitor, termed ALT-007, targeting the rate-limiting enzyme of ceramide synthesis, serine palmitoyltransferase (SPT).

Infection with Toxoplasma gondii triggers coagulation at the blood-brain barrier and a reduction in cerebral blood flow.

Background: Immunothrombosis is the process by which the coagulation cascade interacts with the innate immune system to control infection. However, the formation of clots within the brain vasculature can be detrimental to the host. Recent work has demonstrated that Toxoplasma gondii infects and lyses central nervous system (CNS) endothelial cells that form the blood-brain barrier (BBB).

Temporal epidemiological profile of oral potentially malignant disorders in southern Brazil.

The study aimed to investigate oral potentially malignant disorders (OPMDs) diagnosed in an Oral Pathology service in southern Brazil over a span of 56 years and to assess the factors influencing their severity and outcomes. A retrospective analysis of histopathological records from 1965 to 2021 was performed. Lesions diagnosed as leukoplakia, erythroplakia, leukoerythroplakia, or actinic cheilitis were included.

Maternal Low-Protein Diet During Nursing Leads to Glucose-Insulin Dyshomeostasis and Pancreatic-Islet Dysfunction by Disrupting Glucocorticoid Responsiveness in Male Rats.

Both perinatal malnutrition and elevated glucocorticoids are pivotal triggers of the growing global pandemic of metabolic diseases. Here, we studied the effects of metabolic stress responsiveness on glucose-insulin homeostasis and pancreatic-islet function in male Wistar offspring whose mothers underwent protein restriction during lactation. During the first two weeks after delivery, lactating dams were fed a low-protein (4% protein, LP group) or normal-protein diet (22.

Antioxidant activity, phytochemical composition, and antitumor capacity of Amazonian fruits taperebá (Spondias mombin) and murici (Byrsonima crassifolia).

The Amazon rainforest is renowned for its biodiversity and as a reservoir of edible and medicinal plants. The phytochemicals in murici and taperebá fruits serve as natural antioxidants, contributing to cultural preservation, ecosystem protection, and economic opportunities. However, limited scientific research on their composition and health benefits hinders their recognition as functional foods.

Analysis of topical conjunctival microbiotic cultures in patients treated with intravitreal injections using antibiotic prophylaxis with 0.3% ofloxacin eye drops.

Background: Intravitreal injections, a relatively recent treatment in ophthalmology, is being adopted rapidly worldwide and becoming one of the most common therapies in the field. Numerous complications are associated with this treatment, ranging from minor inflammatory ailments to endophthalmitis. We analyzed the conjunctival flora of patients treated with intravitreal injections and topical antibiotics.

Educational technologies to promote the quality of life of people with diabetes: quasi-experimental study.

Objective: to verify the effect of educational technologies on the quality of life of people with diabetes.

Method: quasi-experimental study, before-and-after type, developed with a group of 34 people. Six interventions were carried out, in groups or individually, using educational technologies, such as clinical simulators and physical educational games.

Diagnose of soil fertility properties of a representative agricultural mesoregion in the Cerrado biome as affected by land use.

In Brazil, most of cereal production is concentrated in the Cerrado which is characterized by poor soils. Thus, the soil fertility management is important for suitable use of Cerrado's soils. After 40 years of increasing use of Cerrado for agricultural purposes, this work aimed to evaluate the soil fertility of a representative area known as Triângulo Mineiro and Alto Paranaíba (TMAP) mesoregion.

Effects of a worksite labor gymnastics program on novice and experienced workers.

Introduction: Worksite labor gymnastics programs are interventions that can positively affect industrial workers. Studies show that experienced and novice workers perceive their working conditions differently. Our premise is that labor gymnastics programs affect these two groups diversely.

Telemedicine minimum viable product for post-exposure prophylaxis to biological material in the COVID-19 pandemic.

Introduction: The COVID-19 pandemic brought new challenges for health services. The follow-up of cases of exposure to biological material is regulated by protocols of the Ministry of Health in Brazil. Telemedicine can be useful in maintaining appointments and reducing patient crowding.

Assessment of toxicity and endocrine-disrupting activity of bisphenol analogues during ozone and UV treatments in zebrafish eleutheroembryos.

In recent decades, increased regulations on the use of bisphenol A (BPA) have prompted a surge in the use of BPA alternatives. Consequently, a widespread occurrence of BPA substitutes in aquatic environments is currently being detected. While some evidence exists about the degradation of these compounds through various water treatment technologies, the evolution of the resulting toxicity and endocrine-disrupting activity during these processes remains scarcely evaluated.

Engineering cellular redox homeostasis to optimize ethanol production in xylose-fermenting Saccharomyces cerevisiae strains.

The transition from fossil fuels dependency to embracing renewable alternatives is pivotal for mitigating greenhouse gas emissions, with biorefineries playing a central role at the forefront of this transition. As a sustainable alternative, lignocellulosic feedstocks hold great promise for biofuels and biochemicals production. However, the effective utilization of complex sugars, such as xylose, remains a significant hurdle.

Intraspecific venom variation in the Iberian asp viper (Vipera aspis zinnikeri) across natural and intensive agricultural habitats.

Snake venom composition varies at different levels. To date, comparative venom studies have seldom taken into account the role of habitat type in the occurrence of snake venom variation. Here we investigated the presence of venom variation across different populations of the Iberian asp viper (Vipera aspis zinnikeri) inhabiting two contrasting habitats: natural vs.

Individual and Joint Association between Cardiovascular Disease Risk Factors and Inadequate Lifestyle Behaviors in a Sample from Brazil.

Background: Individual and Joint Association between Cardiovascular Disease Risk Factors and Inadequate Lifestyle Behaviors in a Sample from Brazil. CVD: cardiovascular diseases.

Background: Cardiovascular diseases (CVD) are often influenced by modifiable factors, notably individuals' lifestyle choices, which play a crucial role in modulating cardiovascular risk.

Photoinactivation of Multidrug-Resistant -Positive Using PCPDTBT Conjugated Polymer Nanoparticles under White Light.

The issue of antimicrobial resistance is an escalating concern within the scope of global health. It is predicted that the existence of antibiotic-resistant bacteria might result in an estimated annual death of up to 10 million by 2050, along with possible economic losses ranging from 100 to 210 trillion. This study reports the production of poly[2,6-(4,4-bis(2-ethylhexyl)-4H-cyclopenta[2,1-b;3,4-b']dithiophene)--4,7(2,1,3-benzothiadiazole)] nanoparticles (PCPDTBT-NPs) by nanoprecipitation as an alternative to tackle this problem.

A double ttrA and pduA knock-out mutant of Salmonella Typhimurium is not attenuated for mice (Mus musculus).

Despite numerous studies on Salmonella enterica subsp. enterica serovar Typhimurium, the underlying mechanisms of several aspects of its virulence are still under investigation, including the role of the pdu and ttrA genes, associated with the metabolism of 1,2-propanediol using tetrathionate as an electron acceptor respectively. Our objective was to contribute to an understanding of the role of these genes inbacterial virulence for mice (Mus musculus) using an S.

Carbohydrate-Binding Mechanism of the Coagulant Lectin from Seeds (cMoL) Is Related to the Dimeric Protein Structure.

This study characterized the binding mechanisms of the lectin cMoL (from Moringa oleifera seeds) to carbohydrates using spectroscopy and molecular dynamics (MD). The interaction with carbohydrates was studied by evaluating lectin fluorescence emission after titration with glucose or galactose (2.0-11 mM).