The efficacy of probiotics in the management of intra-oral halitosis: a systematic review.

Objectives: To evaluate the efficacy of probiotics in reducing halitosis of dental origin.

Methods: MEDLINE, EMBASE, and CENTRAL were searched up to and including June 2020. Randomised placebo-controlled, double-blinded clinical trials in systemically healthy adult patients who were given any form of probiotics to manage halitosis of dental origin were included.

Adjunctive probiotics after periodontal debridement versus placebo: a systematic review and meta-analysis.

Objective: To comprehensively investigate the efficacy of adjunctive probiotics compared to placebo, using conventional and novel treatment outcomes.

Materials And Methods: Three databases (MEDLINE, EMBASE, and CENTRAL) were searched. Outcomes included percent change in the total number of deep sites before and after therapy, change in mean probing pocket depth (mm), percentage patients requiring additional therapy, risk for disease progression, and microbiological and immunological results.

Influence of periodontal maintenance and periodontitis susceptibility on implant success: A 5-year retrospective cohort on moderately rough surfaced implants.

Objectives: To investigate the effect of defined versus undefined periodontal maintenance after implant therapy on the prevalence of peri-implant complications.

Material And Methods: Two hundred patients who underwent dental implant therapy in the National Dental Centre Singapore (NDCS) from 2005 to 2012 were recruited. One hundred patients had regular periodontal maintenance (defined maintenance programme group, DMP), and the other 100 patients had no documentation of periodontal maintenance (undefined maintenance programme group, UMP).

An Overview of Different Interdental Cleaning Aids and Their Effectiveness.

Optimisation of plaque control is essential for the success of non-surgical and surgical periodontal therapy. This cannot be achieved with brushing alone; hence, there is a need for adjunctive interdental cleaning aids. The aim of this paper is to provide an overview of different interdental cleaning aids and review the literature for consensus on their effectiveness.

Mesenchymal stem cell exosomes enhance periodontal ligament cell functions and promote periodontal regeneration.

Mesenchymal stem cells (MSCs) are potential therapeutics for the treatment of periodontal defects. It is increasingly accepted that MSCs mediate tissue repair through secretion of trophic factors, particularly exosomes. Here, we investigated the therapeutic effects of human MSC exosome-loaded collagen sponge for regeneration of surgically created periodontal intrabony defects in an immunocompetent rat model.

Effects of root debridement and adjunctive photodynamic therapy in residual pockets of patients on supportive periodontal therapy: A randomized split-mouth trial.

Background: The study aims to compare the effects of adjunctive photodynamic therapy (PDT) with scaling and root debridement alone on periodontal parameters and inflammatory cytokines in residual pockets of patients undergoing maintenance therapy.

Methods: 27 subjects, each with at least 2 residual pockets ≥5mm, were recruited for this randomized, split-mouth controlled trial, providing total of 72 sites. Probing pocket depth (PPD), recession, clinical attachment loss (CAL), plaque and bleeding on probing of all sites were examined at baseline, 3 and 6 months.

Fact or Fiction? Powered Toothbrushing is More Effective than Manual Toothbrushing.

Purpose: To answer the question of whether powered toothbrushing is more effective than manual toothbrushing, this paper reviews various aspects of powered toothbrushes in terms of efficacy, safety, acceptability and special considerations for certain patient groups. Future research directions and gaps in the current knowledge are also discussed.

Materials And Methods: The literature review was conducted using PubMed.

Implant maintenance for the prevention of biological complications: Are you ready for the next challenge?

With increasing knowledge of wound biology and material sciences, the provision of dental implants as a treatment modality has become increasingly predictable and more commonly used to replace missing teeth. However, without appropriate follow up, peri-implant diseases could develop and affect the long-term success of implants. Currently, there is not enough focus on the prevention of peri-implant diseases, as compared to the definition of the disease, its prevalence, and treatment.

Dual delivery of PDGF and simvastatin to accelerate periodontal regeneration in vivo.

The emphasis on periodontal regeneration has been shifted towards the harmonization of bioactive molecules and physiological phases during regeneration. This study investigated whether the combination and sequential-release of platelet-derived growth factor (PDGF, mitogen) and simvastatin (differentiation factor) facilitated periodontal regeneration. PDGF and simvastatin were encapsulated in double-walled poly-( d,l-lactide) and poly-(d,l-lactide-co-glycolide) (PDLLA-PLGA) microspheres using the co-axial electrohydrodynamic atomization technique.

Sequential platelet-derived growth factor-simvastatin release promotes dentoalveolar regeneration.

Objectives: Timely augmentation of the physiological events of dentoalveolar repair is a prerequisite for the optimization of the outcome of regeneration. This study aimed to develop a treatment strategy to promote dentoalveolar regeneration by the combined delivery of the early mitogenic factor platelet-derived growth factor (PDGF) and the late osteogenic differentiation factor simvastatin.

Materials And Methods: By using the coaxial electrohydrodynamic atomization technique, PDGF and simvastatin were encapsulated in a double-walled poly(D,L-lactide) and poly(D,L-lactide-co-glycolide) (PDLLA-PLGA) microspheres in five different modes: microspheres encapsulating bovine serum albumin (BB), PDGF alone (XP), simvastatin alone (SB), PDGF-in-core and simvastatin-in-shell (PS), and simvastatin-in-core and PDGF-in-shell (SP).

Aminoguanidine inhibits the AGE-RAGE axis to modulate the induction of periodontitis but has limited effects on the progression and recovery of experimental periodontitis: a preliminary study.

Background: Advanced glycation end products (AGE) have been found in inflamed gingival tissue and have been shown to interfere with the integrity of extracellular matrix and cell-matrix interactions. This study aims to investigate the modulatory effect of aminoguanidine (AG), an AGE inhibitor, in various stages of experimental periodontitis.

Methods: Thirty-six Sprague-Dawley rats were used.

Tooth loss in compliant and non-compliant periodontally treated patients: 7 years after active periodontal therapy.

Aims: To investigate the incidence and reasons for tooth loss during active periodontal therapy (APT) and periodontal maintenance (PM) in a specialist institution.

Material And Methods: Retrospective data were collected from 273 patients [all compliers (AC)] and cross-sectional data from 39 patients after discontinuation of PM [non-compliers (NC)] for at least 7 years after APT. Descriptive statistics and regression analysis were performed.

The width of the attached gingiva--much ado about nothing?

Objectives: This narrative review aims to outline the concepts on the significance of the width of attached gingiva around teeth and implants to enable the clinician to decide on the need for gingival augmentation in different clinical scenarios.

Data And Sources: An electronic search was done on PUBMED & Cochrane Database using the keywords from 1972 to November 2009. A manual hand search was also done in Journal of Periodontology and Journals of Clinical Periodontology for relevant articles under this topic.

Implant placement in extraction sockets: a short review of the literature and presentation of a series of three cases.

Successful placement of dental implants in extraction sockets has been reported in the literature. There are numerous practical considerations in relation to immediate implant placement that make the procedure more complex as compared with placement in healed extraction sites. A short review of the literature is presented to understand the scientific principles and controversies related to immediate implants.

Assessment criteria for compliance with oral hygiene: application of ROC analysis.

Purpose: Diabetes is an established risk factor for periodontal disease. Management of periodontal disease is highly dependent upon effective oral hygiene. Assessment of plaque and gingivitis has been commonly used and arbitrarily set in clinical practice to evaluate patients' adherence with oral hygiene recommendations.

Management of retrograde peri-implantitis: a clinical case report.

The term retrograde peri-implantitis has been commonly used to describe lesions in the periapical region of dental implants. There are very few reports on this condition, and the exact etiology and pathogenesis are subject to speculation. Management of retrograde peri-implantitis is even more scarcely discussed in the literature.

Diabetes as a risk factor for periodontal disease: current status and future considerations.

Introduction: Over the past decade, there has been an emerging interest in the interrelationship between systemic conditions and oral health. Diabetes is perhaps one of the best documented conditions that have been closely linked with periodontal disease. This paper reviews the role of diabetes as a risk factor in periodontal disease.

Salivary biomarkers associated with academic assessment stress among dental undergraduates.

This study aims to assess the difference in self-perceived stress before and after an academic assessment and its association with the marks scored and to study the association of salivary cortisol, Immunoglobulin A (IgA), and chromogranin A (CgA) with stress levels before and after the assessment. Thirty-one third-year dental undergraduates indicated how stressed they felt on a 5-point rating scale just prior to and immediately after a one-hour written test. Five-minute unstimulated whole saliva samples were also collected at those times to measure salivary cortisol, IgA, and CgA.