The effect of workplace bullying on knowledge sharing of the employees in scientific and technological enterprises: a moderated mediation model.

Purpose: This study aims to understand how workplace bullying affects knowledge sharing among employees in Chinese scientific and technological enterprises.

Methodology: A convenience sampling method was employed to survey 275 employees from scientific and technological enterprises of Yangtze River Delta, China. The survey utilized a general information questionnaire, a workplace bullying scale, an organizational belonging scale, a knowledge sharing scale, and a forbearance scale.

Trends in Surgeon Burnout in the US and Canada: Systematic Review and Meta-Regression Analysis.

Background: Burnout among surgeons is increasingly recognized as a crisis. However, little is known about changes in burnout prevalence over time. We evaluated temporal trends in burnout among surgeons and surgical trainees of all specialties in the US and Canada.

Ocular manifestations of ANCA-associated vasculitis.

Objectives: ANCA-associated vasculitis (AAV) is a group of multisystem diseases that can have several ocular manifestations. There are published data on ocular manifestations of granulomatosis with polyangiitis (GPA), but few for eosinophilic granulomatosis with polyangiitis (EGPA) or microscopic polyangiitis (MPA). There is little information concerning chronicity, complications, and association with other cranial manifestations of AAV.

Glimmers of hope in large carnivore recoveries.

In the face of an accelerating extinction crisis, scientists must draw insights from successful conservation interventions to uncover promising strategies for reversing broader declines. Here, we synthesize cases of recovery from a list of 362 species of large carnivores, ecologically important species that function as terminal consumers in many ecological contexts. Large carnivores represent critical conservation targets that have experienced historical declines as a result of direct exploitation and habitat loss.

Study on the Relationship Between Confucian Filial Piety Culture and Chinese Youth's Entrepreneurial Intention.

As an important part of entrepreneurial environment, Culture directly or indirectly affects individual entrepreneurial intention. Taking young students as the survey object, this paper uses empirical research methods to explore the relationship between Confucian filial piety culture and Chinese youth's entrepreneurial intention. The results show that there is a positive correlation between Confucian filial piety culture and Chinese youth's entrepreneurial intention, achievement motivation, risk-taking tendency and self-efficacy; Confucian filial piety culture has not only a direct effect on Chinese youth's entrepreneurial intention, but also an indirect effect with achievement motivation, self-efficacy and risk-taking tendency as intermediary variables.

Remoteness does not enhance coral reef resilience.

Remote coral reefs are thought to be more resilient to climate change due to their isolation from local stressors like fishing and pollution. We tested this hypothesis by measuring the relationship between local human influence and coral community resilience. Surprisingly, we found no relationship between human influence and resistance to disturbance and some evidence that areas with greater human development may recover from disturbance faster than their more isolated counterparts.

Eyelid-Cheek Junction Soft-Tissue Perineurioma: Case Report and Controversies.

Perineurioma is a rare soft-tissue tumor with characteristic histologic and immunohistochemical features. The diagnosis; however, can be met with certain challenges. A 71-year-old woman presented with an enlarging painless mass in the right lower eyelid-cheek junction.

The Relationship Between Entrepreneurial Intention and Action: The Effects of Fear of Failure and Role Model.

The purpose of the study was to examine the moderating effect of business role model and fear of failure on the relationship between entrepreneurial intention and behavior. The participants were sampled from 1865 college students who graduated from universities in China from 2012 to 2018. The experimental instrument was comprised of four scales concerning entrepreneurial intention, entrepreneurial behavior, fear of failure, and business role model.

Differential Outcomes and Biologic Markers of Radiation-Associated vs. Sporadic Osteosarcoma: A Single-Institution Experience.

Radiation-associated osteosarcoma (RAO) is a rare, life-threatening complication from radiation. Many physicians presume RAO has a worse prognosis than sporadic osteosarcoma (SO), although limited objective data exist. We conducted a retrospective study comparing these entities.

Anisotropic Material Characterization of Human Cervix Tissue Based on Indentation and Inverse Finite Element Analysis.

The cervix is essential to a healthy pregnancy as it must bear the increasing load caused by the growing fetus. Preterm birth is suspected to be caused by the premature softening and mechanical failure of the cervix. The objective of this paper is to measure the anisotropic mechanical properties of human cervical tissue using indentation and video extensometry.

Long non-coding RNA LINC00641 suppresses non-small-cell lung cancer by sponging miR-424-5p to upregulate PLSCR4.

Non-small cell lung cancer (NSCLC) , as the most prevalent type of lung carcinoma with high severity, is of urgent necessity to be investigated for novel therapeutic strategies. Long non-coding RNAs (lncRNAs) are notable for their participation in cancer regulation, and lncRNA long intergenic non-protein coding RNA 641 (LINC00641) has been found to have an inhibitory influence on bladder cancer, but its role in NSCLC has not yet been studied. In this research, we launched an investigation into the biological functions and the underlying molecular mechanisms of LINC00641 in NSCLC.

Farmers' Work-Life Quality and Entrepreneurship Will in China.

New-generation farmers have become a vital force for entrepreneurship in their hometowns. To better promote farmers to start businesses, it's important to know about their quality of work life. Based on a survey of the quality of work life and entrepreneurship will of farmers from three cities and eight counties in Shandong province of China, this paper analyzed the effects of farmers' quality of work life on their entrepreneurship will in their hometowns using a Logistic regression model.

Ophthalmology referrals from optometry: a comparative study (the R.O.C.S study).

Objective: To characterize emergency optometrist referrals triaged at a tertiary ophthalmology care centre by physical examination findings and provisional diagnosis accuracy.

Design: Prospective case review.

Participants: Consecutive patients referred to a tertiary eye care clinic for an after-hours ocular consult.

Patient satisfaction with wait times at an emergency ophthalmology on-call service.

Objective: To assess patient satisfaction with emergency ophthalmology care and determine the effect provision of anticipated appointment wait time has on scores.

Design: Single-centre, randomized control trial.

Participants: Fifty patients triaged at the Hamilton Regional Eye Institute (HREI) from November 2015 to July 2016.

Effect of ultrasound pretreatment on rennet-induced coagulation properties of goat's milk.

The effects of ultrasound (US) pretreatment on goat milk before rennet-induced coagulation were studied in order to improve the milk coagulation properties. Skimmed goat milk was subjected to US at 800 W for different times (0-20 min) and various parameters were evaluated. The particle sizes in US pretreated goat milk under the transmission electron microscopy were smaller than in untreated samples.

Expression of αB-crystallin and its potential anti-apoptotic role in oral verrucous carcinoma.

αB-crystallin, a member of the small heat shock protein family, acts as a molecular chaperone. αB-crystallin has been found to be overexpressed in a number of cancer tissues, including head and neck cancers. Overexpression of αB-crystallin in cancer tissue may be related to its anti-apoptotic properties; however, its mechanism of action remains unclear.

The effect of food on the bioavailability of panobinostat, an orally active pan-histone deacetylase inhibitor, in patients with advanced cancer.

Purpose: Panobinostat is a novel oral pan-deacetylase inhibitor with promising anti-cancer activity. The study aimed to determine the influence of food on the oral bioavailability of panobinostat.

Methods: This multicenter study consisted of a randomized, three-way crossover, food-effect study period (cycle 1) followed by single-agent panobinostat continual treatment phase in patients with advanced cancer.

Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor.

Purpose: Panobinostat is partly metabolized by CYP3A4 in vitro. This study evaluated the effect of a potent CYP3A inhibitor, ketoconazole, on the pharmacokinetics and safety of panobinostat.

Methods: Patients received a single panobinostat oral dose on day 1, followed by 4 days wash-out period.

Effects of nilotinib on single-dose warfarin pharmacokinetics and pharmacodynamics: a randomized, single-blind, two-period crossover study in healthy subjects.

Background And Objective: Nilotinib (Tasigna®), a highly selective and potent BCR-ABL tyrosine kinase inhibitor, is approved for the treatment of chronic myeloid leukaemia in the chronic phase (CML-CP) and the accelerated phase (CML-AP) in patients resistant or intolerant to prior therapy, including imatinib. Nilotinib has shown competitive inhibition of cytochrome P450 enzyme (CYP) 2C9 in vitro, but its effect on CYP2C9 activity in humans is unknown. This study evaluated the effects of nilotinib on the pharmacokinetics and pharmacodynamics of warfarin, a sensitive CYP2C9 substrate, in healthy subjects.