Publications by authors named "Lily Houlden"
Article Synopsis
- Dolutegravir (DTG) is metabolized in the body, producing an inactive form called DTG glucuronide (DTG-gluc), and the study focused on its metabolic ratio (DTG-MR) among 85 HIV-positive children aged 3 months to 18 years.
- The research found that the overall DTG-MR in children was similar to that in adults and was primarily influenced by the use of rifampicin, which significantly increased the DTG-MR.
- These results suggest that factors like age, body weight, and type of NRTI treatment do not affect the DTG-MR in children, paving the way for better pharmacokinetic modeling for pediatric patients based on adult data
The mechanisms of how chemotherapeutic drugs lead to cell cycle checkpoint regulation and DNA damage repair are well understood, but how such signals are transmitted to the cellular apoptosis machinery is less clear. We identified a novel apoptosis-inducing complex, we termed FADDosome, which is driven by ATR-dependent caspase-10 upregulation. During FADDosome-induced apoptosis, cFLIP is ubiquitinated by TRAF2, leading to its degradation and subsequent FADD-dependent caspase-8 activation.
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