Multisite Head and Neck Pediatric Posttransplant Lymphoproliferative Disorder: A Case Report.

Posttransplant lymphoproliferative disorder (PTLD) can mimic infectious processes in the head and neck. A high index of suspicion for PTLD must be maintained in pediatric transplant patients, and minimal response to antibiotics/corticosteroids should prompt timely biopsy of suspicious tissue to expedite the diagnosis and treatment of PTLD.

Does Palatoplasty Technique Impact Resolution of Eustachian Tube Dysfunction?

Objective: To determine whether palatoplasty technique affects the resolution of eustachian tube dysfunction and postoperative speech outcomes in children with cleft palate (CP).

Design: Retrospective cohort.

Setting: Multidisciplinary cleft and craniofacial clinic at a tertiary care center.

Social network analysis as a new tool to measure academic impact of physicians.

Introduction: H-index is a widely used metric quantifying a researcher's productivity and impact based on an author's publications and citations. Though convenient to calculate, h-index fails to incorporate collaborations and interrelationships between physicians into its assessment of academic impact, leading to limited insight into grouped networks. We present social network analysis as a tool to measure relationships between physicians and quantify their academic impact.

Insight into the Mode of Action of 8-Hydroxyquinoline-Based Blockers on the Histamine Receptor 2.

Histamine receptor 2 (HR) blockers are used to treat peptic ulcers and gastric reflux. Chlorquinaldol and chloroxine, which contain an 8-hydroxyquinoline (8HQ) core, have recently been identified as blocking HR. To gain insight into the mode of action of 8HQ-based blockers, here, we leverage an HR-based sensor in yeast to evaluate the role of key residues in the HR active site on histamine and 8HQ-based blocker binding.