Ge-Zhi-Jie-Jiu decoction alleviates alcoholic liver disease through multiple signaling pathways.

Ethnopharmacological Relevance: Alcoholic liver disease (ALD) is a growing public health concern caused by excessive alcohol consumption, but effective treatments are limited. Ge-Zhi-Jie-Jiu decoction (JJY) is a modified traditional Chinese herbal remedy that aims to alleviate ALD. This formula contains various components such as Ge Hua, Ge Gen, Zhi Ju Zi, and other medicinal-food herbs.

Intranasal Vaccination With Recombinant Antigen-FLIPr Fusion Protein Alone Induces Long-Lasting Systemic Antibody Responses and Broad T Cell Responses.

A simple formulation is urgently needed for mucosal vaccine development. We employed formyl peptide receptor-like 1 inhibitory protein (FLIPr), an FcγR antagonist secreted by , as a vector to target ovalbumin (OVA) to dendritic cells (DCs) intranasal administration. Our results demonstrate that intranasal administration of recombinant OVA-FLIPr fusion protein (rOVA-FLIPr) alone efficiently delivers OVA to DCs in nasal lymphoid tissue.

Potassium Regulation in Medaka (Oryzias latipes) Larvae Acclimated to Fresh Water: Passive Uptake and Active Secretion by the Skin Cells.

Molecular mechanisms of Na, Cl, and Ca regulation in ionocytes of fish have been well investigated. However, the regulatory mechanism of K in fishes has been largely unknown. In this study, we investigated the mechanism of K regulation in medaka larvae acclimated to fresh water.