Oxidized Phospholipid oxPAPC Alters Regulatory T-Cell Differentiation and Decreases Their Protective Function in Atherosclerosis in Mice.

Background: Regulatory T cells (T) are protective in atherosclerosis but reduced during disease progression due to cell death and loss of stability. However, the mechanisms of T dysfunction remain unknown. Oxidized phospholipids are abundant in atherosclerosis and can activate innate immune cells, but little is known regarding their impact on T cells.