Publications by authors named "Lillian N Gomes"
In this study, we investigated the role of extracellular vesicles (EVs) in the pathogenesis of Congenital Zika Syndrome (CZS). Previous studies have highlighted the role of EVs in intercellular communication and the modulation of biological processes during viral infections, motivating our in-depth analysis. Our objective was to identify specific molecular signatures in the EVs of patients with CZS, focusing on their potential as biomarkers and on cellular pathways affected by the infection.
View Article and Find Full Text PDFArticle Synopsis
- ISG15 deficiency is a rare inherited syndrome that leads to frequent infections by less harmful mycobacteria and interferon-related issues, and this study focuses on two unrelated Brazilian patients sharing the same genetic mutation in the ISG15 gene.
- Assessments revealed both patients had low production of IFN-γ and distinct clinical symptoms, impacting their immune response and leading to both infectious and neurological manifestations.
- The researchers identified a specific mutation (c.83 T > A) that destabilizes the ISG15 protein, along with a significant number of differentially expressed genes linked to immune pathways, marking the first documentation of these cases in Brazil.
Brazil is one of the countries that experienced an epidemic of microcephaly and other congenital manifestations related to maternal Zika virus infection which can result in Congenital Zika Syndrome (CZS). Since the Zika virus can modulate the immune system, studying mothers' and children's immune profiles become essential to better understanding CZS development. Therefore, we investigated the lymphocyte population profile of children who developed CZS and their mothers' immune response in this study.
View Article and Find Full Text PDFThe immunological mechanisms involved in the development of congenital Zika syndrome (CZS) have yet to be fully clarified. This study aims to assess the immuno-inflammatory profile of mothers and their children who have been diagnosed with CZS. Blood samples, which were confirmed clinically using the plaque reduction neutralization test (PRNT), were collected from children with CZS and their mothers (CZS+ group).
View Article and Find Full Text PDFHydroalcoholic Leaf Extract of , alone and in Combination with Calcium Hydroxide, Is Effective against Mono- and Polymicrobial Biofilms of and .
Antibiotics (Basel)
April 2022
Failures in endodontic treatments are mostly associated with the difficulty in eradicating microbes of the root canal system, highlighting the need to develop novel effective antimicrobials. (pomegranate) leaf hydroalcoholic extract may be a potential alternative in canal dressing, owing to its antimicrobial properties. The objective of this study was to evaluate the antimicrobial activity of hydroalcoholic leaf extract of (HEPg) alone or in combination with calcium hydroxide (Ca(OH)) against and in isolation and in mono- and polymicrobial biofilms.
View Article and Find Full Text PDFArticle Synopsis
- * Researchers analyzed data from 50 patients, noting a median age of 7 months at disease onset and significant delays in diagnosis, along with discovering 6 new mutations in the CD40LG gene.
- * Common symptoms included pneumonia, respiratory infections, and various gastrointestinal issues, with the study documenting the largest number of infectious agents associated with this condition, enhancing insights for diagnosis and management.
The short duration of viremia, low blood viral load, inaccessibility to timely specific diagnostic tests, and cross-reactions with other flaviviruses have hindered laboratory confirmation of Congenital Zika Syndrome (CZS). This study analyzes the positivity of the plaque reduction neutralization test (PRNT) in children with clinical or imaging characteristics of CZS and its association with laboratory, clinical, and imaging characteristics. The 94 clinical cases of CZS submitted to the ZIKV PRNT test were followed from 2016 to 2018.
View Article and Find Full Text PDFBackground: Little information on gross motor function of congenital Zika syndrome (CZS) children is available.
Objectives: To evaluate gross motor function in CZS children aged up to 3 years, and its associated factors and changes in a minimum interval of 6 months.
Methods: One hundred children with CZS and cerebral palsy (36 with confirmed and 64 with presumed CZS) were evaluated with the Gross Motor Function Classification System (GMFCS) and Gross Motor Function Measure (GMFM-88/GMFM-66).
Zika virus cases in Brazil have diminished since emergence in 2015. We report Guillain Barré Syndrome caused by Zika and possible Chikungunya co-infection during an expected low arboviral season. This case highlights the importance of clinical vigilance for Zika in those with neurological syndromes outside typical arboviral season.
View Article and Find Full Text PDFArticle Synopsis
- Salvador was significantly impacted during the 2015 Zika virus outbreak, prompting a study involving parturients (pregnant women) and their newborns.
- The study found that 6.9% of parturients tested positive for Zika virus (ZIKV), with higher rates of exposure to dengue (DENV) and Chikungunya (CHIKV) reflected in antibody tests.
- The results emphasized the importance of prenatal and neonatal screening for ZIKV and CHIKV due to the occurrence of congenital infections observed in 16.5% of newborns for ZIKV and 13% for CHIKV.
Purpose Of Review: We briefly address the advances in genetics, pathophysiology, and phenotypes of chronic granulomatous disease (CGD). This is one of the most studied primary immunodeficiencies, which comprise mutations in genes encoding the different subunits of the NADPH oxidase system. Those mutations lead to defective reactive oxygen species production, and consequently a failure to eliminate pathogens.
View Article and Find Full Text PDF