Electrode configurations for sensitive and specific detection of compound muscle action potentials to the tibialis anterior muscle after peroneal nerve injury in rats.

Background: Quantifying peripheral nerve regeneration via electrophysiology is a commonly used technique, but it can be complicated by spurious electrical activity. This study sought to compare electrode configurations for measuring compound muscle action potential (CMAP) of the tibialis anterior (TA) muscle in a rat model for specific and sensitive detection of regeneration of peroneal nerve to the TA.

New Method: 10 Sprague-Dawley rats underwent a peroneal nerve transection with direct microsuture repair.