Dorsal rhinotomy in a dog with a chondro-osseous respiratory epithelial adenomatoid hamartoma: a case report.

Objective: To describe the clinical presentation, novel surgical approach, and outcome of a dog diagnosed with chondro-osseous respiratory epithelial adenomatoid hamartoma (COREAH).

Animal: 5-year-old castrated male Yorkshire Terrier.

Clinical Presentation, Progression, And Procedures: The dog was presented with chronic upper respiratory noise, congestion, facial swelling, ocular discharge, and an abscess on the nasal bridge.

Effect of metastatic calcification on complication rate and survival in 74 renal transplant cats (1998-2020).

Objective: To report the incidence of metastatic calcification in cats with renal failure presenting for renal transplantation, and to determine if metastatic calcification detected prior to renal transplantation is associated with complication rates and patient survival.

Study Design: Retrospective case series.

Sample Population: Seventy-four cats.

cDC1 coordinate innate and adaptive responses in the omentum required for T cell priming and memory.

In the peritoneal cavity, the omentum contains fat-associated lymphoid clusters (FALCs) whose role in response to infection is poorly understood. After intraperitoneal immunization with , conventional type 1 dendritic cells (cDC1s) were critical to induce innate sources of IFN-γ and cellular changes in the FALCs. Unexpectedly, infected peritoneal macrophages that migrated into the FALCs primed CD8 T cells.

Characterization of preoperative cardiovascular status and association with outcome following feline renal allograft transplantation: 166 cases.

Objectives: To retrospectively evaluate preoperative historical, biochemical, and cardiovascular screening data for predictors of survival to discharge and long-term survival in feline renal allograft recipients from 1 institution.

Animals: 166 cats that underwent renal transplantation at the University of Pennsylvania between 1998 and 2018.

Procedures: Medical records were reviewed for preoperative historical information, biochemical data, and cardiac assessment including auscultation findings, pre- and postoperative systolic blood pressure measurements, thoracic radiographic evaluation, and echocardiographic measurements.

Transpelvic urethrostomy in a female dog with congenital vestibulovaginal and urethral stenosis: A case report.

Objective: To describe transpelvic urethrostomy (TPU) as a surgical technique for the successful treatment of vestibulovaginal and urethral stenosis in a 7 month old female spayed mixed-breed dog.

Study Design: Case report.

Sample Population: Female spayed mixed-breed dog with obstructive vaginal tissue present on vaginal examination.

Bilateral renal descensus and intravesicular ureteroneocystostomy for treatment of bilateral ureteral ligation and transection that occurred during ovariohysterectomy in two cats.

Case Description: 6-month-old and 7-month-old spayed female domestic shorthair cats were referred because of complications associated with inadvertent bilateral ureteral ligation and transection during ovariohysterectomy.

Clinical Findings: Both cats had a 1- to 2-day history of lethargy, inappetence, and vomiting. Initial exam findings included lethargy, signs of abdominal pain, anuria, and dehydration.

infection in feline renal transplant recipients: 24 cases (1998-2018).

Objective: To evaluate the effects of infection in feline renal transplant recipients with a preoperative seronegative or unknown serostatus (SN-UNK) for and the efficacy of lifelong prophylactic treatment of infection in feline renal transplant recipients with a preoperative seropositive serostatus (SP) for .

Animals: 24 cats with various serostatuses for before undergoing renal transplantation.

Procedures: Medical records of cats that had undergone renal transplantation from 1998 through 2018 were reviewed.

Loss of IL-27Rα Results in Enhanced Tubulointerstitial Fibrosis Associated with Elevated Th17 Responses.

Clinical and experimental studies have established that immune cells such as alternatively activated (M2) macrophages and Th17 cells play a role in the progression of chronic kidney disease, but the endogenous pathways that limit these processes are not well understood. The cytokine IL-27 has been shown to limit immune-mediated pathology in other systems by effects on these cell types, but this has not been thoroughly investigated in the kidney. Unilateral ureteral obstruction was performed on wild-type and IL-27Rα mice.

Congenital sternal defect repair in an adult cat with incomplete pentalogy of Cantrell.

Case Description: A 1-year-old spayed female domestic shorthair cat was evaluated for a sternal defect and ventral abdominal wall hernia.

Clinical Findings: The cat appeared healthy. Palpation revealed a sternal defect, and the heart could be observed beating underneath the skin at the caudoventral aspect of the thorax.

Diagnostic utility of ultrasonography for detection of the cause and location of ureteral obstruction in cats: 71 cases (2010-2016).

OBJECTIVE To assess the utility of ultrasonography to detect the cause and location of ureteral obstruction in cats and to identify factors associated with agreement between ultrasonographic and surgical findings. STUDY DESIGN Retrospective case series. ANIMALS 71 cats.

Radiographic distribution of ureteral stones in 78 cats.

Objective: To document the distribution of ureteral stones in cats.

Study Design: Retrospective case series.

Animals: Seventy-eight cats.

Renal cell carcinoma in a cat with polycystic kidney disease undergoing renal transplantation.

Case Summary: A 10-year-old spayed female American Shorthair cat underwent renal transplantation due to worsening chronic kidney disease secondary to polycystic kidney disease. During transplantation, the right kidney grossly appeared to be more diseased than the left and was firmly adhered to the surrounding tissues. An intraoperative fine-needle aspirate of the right native kidney revealed inflammatory cells but no evidence of neoplasia.

Validation of a model of feline ureteral obstruction as a tool for teaching microsurgery to veterinary surgeons.

Objective: To assess the content and face validity of a model of an obstructed feline ureter as a tool for teaching ureteral microsurgery.

Study Design: Prospective, experimental study.

Sample Population: Seven expert and 11 novice microsurgeons.

Heterozygosity for P2Y12 receptor gene mutation associated with postoperative hemorrhage in a Greater Swiss Mountain dog.

A 3-year-old, female Greater Swiss Mountain dog developed a hemoperitoneum following an exploratory laparotomy and ovariohysterectomy. Platelet count, PT, APTT, and plasma von Willebrand factor antigen concentration were within RIs. A buccal mucosal bleeding time (BMBT) was prolonged.

Update on the Current Status of Kidney Transplantation for Chronic Kidney Disease in Animals.

Kidney transplantation is a novel treatment option for cats suffering from chronic renal failure or acute irreversible renal injury. Improvement in quality of life as well as survival times of cats that have undergone transplantation has helped the technique to gain acceptance as a viable treatment option for this fatal disease. This article reviews information regarding the optimal time for intervention, congenital and acquired conditions that have been successfully treated with transplantation, recipient and donor screening, immunosuppressive therapy, recent advances in anesthetic and surgical management, postoperative monitoring and long-term management, and troubleshooting perioperative and long-term complications.

Outcomes of ureteral surgery and ureteral stenting in cats: 117 cases (2006-2014).

Objective: To evaluate and compare outcomes in cats following ureteral surgery or ureteral stent placement.

Design: Retrospective case series.

Animals: 117 cats.

Influence of anesthetic variables on short-term and overall survival rates in cats undergoing renal transplantation surgery.

Objective: To identify factors associated with short-term (30-day) and overall survival rates in cats that underwent renal transplantation surgery (RTS).

Design: Retrospective cohort study.

Animals: 94 cats that underwent RTS from 1998 through 2010.

End-to-end ureteral anastomosis and double-pigtail ureteral stent placement for treatment of iatrogenic ureteral trauma in two dogs.

Case Description: A 6-month-old spayed female Soft-Coated Wheaten Terrier and 8-month-old spayed female Shih Tzu were referred because of complications related to inadvertent ureteral ligation and transection during recent ovariohysterectomy.

Clinical Findings: The Soft-Coated Wheaten Terrier had a 2-day history of stranguria and polyuria that began after ovariohysterectomy. Initial examination findings were unremarkable with the exception of high rectal temperature.

Septicemia and Infection due to ESBL-producing K. pneumoniae Following Feline Renal Allograft Transplantation.

A 12 yr old castrated male domestic longhair underwent renal transplantation for treatment of chronic interstitial nephritis. Full-thickness intestinal biopsies obtained prior to transplantation revealed mild enteritis. Twelve months following transplantation, the patient underwent surgery for resection of a mesenteric mass causing septic peritonitis.

Retroperitoneal fibrosis in feline renal transplant recipients: 29 cases (1998-2011).

Objective: To evaluate features, treatment, and prognosis associated with retroperitoneal fibrosis that developed after renal transplantation in cats.

Design: Retrospective case series.

Animals: 29 cats.

Osteomyelitis of the coxofemoral joint due to Mycobacterium species in a feline renal transplant recipient.

A 4-year-old castrated male Russian Blue cat was evaluated for acute right hind limb lameness 18 months after receiving a renal transplant. Radiographs showed a subluxated right femoral head and lysis of the acetabulum and femoral neck. A femoral head and neck ostectomy was performed on the right coxofemoral joint.

Use of end-to-side arterial and venous anastomosis techniques for renal transplantation in two dogs.

Case Description: A sexually intact male Old English Sheepdog and a sexually intact female Bull Terrier were evaluated for renal dysplasia and chronic renal failure, respectively.

Clinical Findings: Both dogs were anemic and had high serum concentrations of urea nitrogen and creatinine. Electrolyte abnormalities (calcium and phosphorus) were also evident.