Publications by authors named "Liliya V Stelmakh"
Trends in Outcome of Hematopoietic Stem Cell Transplantation: 5000 Transplantations and 30 Years of Single-Center Experience.
Cancers (Basel)
September 2023
Article Synopsis
- This analysis reviewed trends in 5185 hematopoietic cell transplantations (HCT) between 1990 and 2022, including 3237 allogeneic (alloHCT) and 1948 autologous (autoHCT) transplants.
- There was a significant improvement in event-free survival (EFS) for both autoHCT and alloHCT over time, attributed to a decrease in relapse rates and non-relapse mortality, respectively.
- Specific survival improvements were noted for various conditions, with autoHCT showing better outcomes in Hodgkin's disease and multiple myeloma, while alloHCT advancements were observed mainly in leukemia and lymphomas.
Background: This study evaluated the distribution of epidermal growth factor receptor (EGFR) T790M mutations in treatment-naïve tumor and normal samples obtained from cancer patients.
Methods: We utilized allele-specific PCR (AS-PCR), digital droplet PCR (ddPCR) and next generation sequencing (NGS) to detect EGFR T790M allele in several collections of tumor and normal human tissues.
Results: AS-PCR analysis of treatment-naïve tumor samples revealed somatic T790M mutation in 3/394 (1%) non-small cell lung carcinomas (NSCLC) carrying the tyrosine kinase inhibitor (TKI)-sensitizing EGFR mutation, but in none of 334 NSCLC lacking EGFR exon 19 deletions (ex19del) or L858R substitutions and in none of 235 non-lung tumors.