Publications by authors named "Liliya Brankova"
Article Synopsis
- Congenital heart defects (CHDs) require surgery often involving cardiopulmonary bypass (CPB), which can result in significant post-operative complications due to an inflammatory response.
- A study examined how peri-operative serum samples from CHD patients affect macrophage inflammatory responses, finding that CPB activates the STAT3 signaling pathway but not NF-κB.
- Pre-treatment with Stattic, a STAT3 inhibitor, reduced various inflammatory mediators in macrophages, except for TNFα, indicating that CPB-induced inflammation is driven by cytokines like IL-6 and IL-8.
Objective: old-inducible RNA binding Protein (CIRBP) has been shown to be a potent inflammatory mediator and could serve as a novel biomarker for inflammation. Systemic inflammatory response syndrome (SIRS) and capillary leak syndrome (CLS) are frequent complications after pediatric cardiac surgery increasing morbidity, therefore early diagnosis and therapy is crucial. As CIRBP serum levels have not been analyzed in a pediatric population, we conducted a clinical feasibility establishing a customized magnetic bead panel analyzing CIRBP in pediatric patients undergoing cardiac surgery.
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