Impact of L-thyroxine on hippocampal activity, morphology, and behavioral performance in thyroidectomized rats.

Thyroid hormones, particularly L-thyroxine, are integral to cognitive processes like learning and memory. However, electrophysiological and morphological evidence connecting thyroid hormone activity to hippocampal function remains limited. This study aims to investigate the electrophysiological, morphological, and behavioral effects of L-thyroxine treatment in thyroidectomized (TX) rats, addressing the complex interplay between thyroid hormone regulation and hippocampal function.