Sexual dimorphism in aortic aneurysm: A review of the contributions of sex hormones and sex chromosomes.

Aortic aneurysm is a common cardiovascular disease. Over time, the disease damages the structural and functional integrity of the aorta, causing it to abnormally expand and potentially rupture, which can be fatal. Sex differences are evident in the disease, with men experiencing an earlier onset and higher incidence.

The association of nutrient intake with epilepsy: A cross-sectional study from NHANES, 2013-2014.

Background: Dietary nutrient supplements are helpful in the treatment of many diseases, but their effect on epilepsy is still controversial. This study aimed to evaluate the association between dietary intake of multiple nutrients and epilepsy.

Methods: A total of 3963 participants from the NHANES database were involved in this study.

Molecular Mechanisms of in Prevention and Treatment of Non-Small-Cell Lung Cancer.

Objective: Lung cancer represents the leading cause of cancer death on a global scale. (), a traditional medicinal material with a high medicinal and health value, has recently been reported for its anticancer activity. However, the pharmacological mechanism of in non-small-cell lung cancer (NSCLC) remains to be elucidated.

LC-ESI-MS/MS determination of simotinib, a novel epidermal growth factor receptor tyrosine kinase inhibitor: application to a pharmacokinetic study.

Simotinib is a novel epidermal growth factor receptor tyrosine kinase inhibitor. This study presented a sensitive and specific liquid chromatography-electrospray ionization-mass spectrometry method using erlotinib as internal standard for the determination of simotinib in human plasma. The method involved a simple liquid-liquid extraction using diethyl ether.

Determination of nifeviroc, a novel CCR5 antagonist: application to a pharmacokinetic study.

Nifeviroc is a novel CCR5 antagonist used for the treatment of HIV type-1 infection. A LC-ESI-MS/MS method for the determination of nifeviroc in human plasma was developed and validated. The calibration curve (r(2)=0.

Solid dispersion of rutaecarpine improved its antihypertensive effect in spontaneously hypertensive rats.

It was reported previously that rutaecarpine produced a hypotensive effect in phenol-induced and 2-kidney, 1-clip hypertensive rats. However, the same dose of crude rutaecarpine did not produce significant hypotensive effects when applied to spontaneously hypertensive rats (SHR). In the present study, a different dose of rutaecarpine solid dispersion was administered intragastrically to SHR.