Sodium alginate aerogel derived SiC@Co-C 3D network enhances electromagnetic wave absorption and thermal conductivity of PDMS based composite.

Interface packaging materials with both electromagnetic wave absorption and high thermal conductivity remains a research hotspot in modern electronics industry and aerospace field. In this paper, the cobalt alginate aerogel derived from biomass sodium alginate was carbothermal reduced to obtain a three-dimensional skeleton structure composed of zero-dimensional Co metal particles, one-dimensional silicon carbide (SiC) whiskers and biomass derived carbon (C). The dielectric-electromagnetic effect of the filler network makes the obtained polydimethylsiloxane (PDMS) based composite (PDMS/SiC@Co-C) exhibits good electromagnetic wave absorption performance, with the lowest reflection loss (RL) value can reach -40.

Crystallization behavior of poly(lactic acid) nucleated by benzoylhydrazide compounds with different methylene numbers: A comparative study.

Poly(lactic acid) (PLA) is an important biobased biodegradable plastics but its inherent crystallization rate is slow. Organic self-assembly nucleating agents have shown excellent nucleating effect in enhancing PLA crystallization. However, the relationship between the chemical structures of organic nucleating agents and their nucleating ability is still not yet well elucidated.

Enhanced fatty acid oxidation via SCD1 downregulation fuels cardiac reprogramming.

Direct cardiac reprogramming has emerged as a promising therapeutic strategy to remuscularize injured myocardium. This approach converts non-contractile fibroblasts to induced cardiomyocytes (iCMs) that spontaneously contract, yet the intrinsic metabolic requirements driving cardiac reprogramming are not fully understood. Using single-cell metabolic flux estimation and flux balance analysis, we characterized the metabolic heterogeneity of iCMs and identified fatty acid oxidation (FAO) as a critical factor in iCM conversion.

The WNT10A gene in ectodermal dysplasias and selective tooth agenesis.

Mutations in the WNT10A gene were first detected in the rare syndrome odonto-onycho-dermal dysplasia (OODD, OMIM257980) but have now also been found to cause about 35-50% of selective tooth agenesis (STHAG4, OMIM150400), a common disorder that mostly affects the permanent dentition. In our random sample of tooth agenesis patients, 40% had at least one mutation in the WNT10A gene. The WNT10A Phe228Ile variant alone reached an allele frequency of 0.

Is there a link between ovarian cancer and tooth agenesis?

An epidemiologic study from the year 2008 found a highly significant increase of congenital tooth agenesis in women with ovarian cancer suggesting that a common genetic etiology may predispose women to both conditions. The finding was reminiscent of a previously described family harboring an AXIN2 mutation which could be shown to segregate with both the tooth agenesis and the predisposition to colon cancer transmitted in this family. Since tooth agenesis as a marker for susceptibility to ovarian cancer would be of great relevance to both oncologists and women with inborn missing teeth, the relationship between the two disorders requires a thorough assessment.

Bisphosphonates inhibit phosphorylation of signal transducer and activator of transcription 3 and expression of suppressor of cytokine signaling 3: implications for their effects on innate immune function and osteoclastogenesis.

Objective: This study tested the effects of bisphosphonates (BPs) on the suppressor of cytokine signaling 3 (SOCS3) protein in macrophages. SOCS3 has been shown to regulate cell differentiation and survival; however, its potential role in mediating the effects of BPs has not been explored.

Study Design: The cell viability of murine RAW 267.

Implications of EGFR inhibition in ovarian cancer cell proliferation.

Objectives: Epidermal Growth Factor Receptor (EGFR) is one of the four members of the Human Epidermal Receptor (HER) family and is over-expressed in multiple malignancies. EGFR over-expression in ovarian cancer has been associated with poor prognosis. Targeted inhibition of EGFR via its tyrosine kinase domain is a successful treatment in lung cancer.

Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors.

Ewing sarcoma is the second most common malignant pediatric bone tumor. Over 80% of Ewing sarcoma contain the oncogene EWS/FLI-1, which encodes the EWS/FLI-1 oncoprotein, a hybrid transcription factor comprised of NH2-terminal sequences from the RNA-binding protein EWS and the DNA-binding and COOH-terminal regions of the Ets transcription factor FLI-1. Although numerous genes are dysregulated by EWS/FLI-1, advances in Ewing sarcoma cancer biology have been hindered by the lack of an animal model because of EWS/FLI-1-mediated cytotoxicity.