Spleen tyrosine kinase (SYK) is a crucial non-receptor tyrosine kinase involved in signaling pathways that regulate various cellular processes. It is primarily expressed in hematopoietic cells and myeloid cells, which are crucial for B-cell development, maturation and antibody production, and it is a key therapeutic target for autoimmune and allergic diseases. Overexpression of SYK is also associated with cancer and cardiovascular, cerebrovascular and neurodegenerative diseases, contributing to their initiation and progression.
View Article and Find Full Text PDFGiven the limited capacity to accurately determine the necessity for intubation in intensive care unit settings, this study aimed to develop and externally validate an interpretable machine learning model capable of predicting the need for intubation among ICU patients. Seven widely used machine learning (ML) algorithms were employed to construct the prediction models. Adult patients from the Medical Information Mart for Intensive Care IV database who stayed in the ICU for longer than 24 h were included in the development and internal validation.
View Article and Find Full Text PDFThe selective recovery of phosphate from wastewater can manage nutrients and realize the recycling of phosphorus resources. In this study, a novel konjac glucomannan/pectin/calcium silicate composite hydrogel (KP-CSH) was developed for efficient recovery of phosphate in aqueous solution. The amount of alkali released after the reaction of KP-CSH in a neutral solution was small (the pH of the solution after the reaction was < 9).
View Article and Find Full Text PDFBackground/aim: Tenofovir amibufenamide (TMF) employs innovative ProTide technology and a methylation strategy to enhance the lipid solubility and plasma stability of the amide bond, providing advantages over tenofovir alafenamide (TAF). Despite promising Phase III clinical trial results demonstrating its antiviral efficacy, real-world data on TMF remains scarce. This study evaluates the antiviral efficacy and safety of TMF compared to TAF as the initial treatment in patients with high viral loads of chronic hepatitis B (CHB).
View Article and Find Full Text PDFUnlabelled: The human immunodeficiency virus type 1 (HIV-1) reservoir consists of latently infected cells which present a major obstacle to achieving a functional cure for HIV-1. The formation and maintenance of HIV-1 latency have been extensively studied, and latency-reversing agents (LRAs) that can reactivate latent HIV-1 by targeting the involved host factors are developed; however, their clinical efficacies remain unsatisfactory. Therefore, it is imperative to identify novel targets for more potential candidates or better combinations for LRAs.
View Article and Find Full Text PDFBackground: Effective prevention is key to addressing the increasing prevalence and mortality of Alzheimer's disease. Assessing the causal relationship between modifiable entertainment activity factors and the risk of Alzheimer's disease is important for developing public health measures, but establishing causal relationships in epidemiological data may be challenging.
Methods: This study using the two-sample Mendelian randomization analysis aimed to investigate the causal effect of entertainment activity factors on the risk of Alzheimer's disease.
Tocotrienols and tocopherols (vitamin E) are potent antioxidants that are synthesized in green plants. Unlike ubiquitous tocopherols, tocotrienols predominantly accumulate in the endosperm of monocot grains, catalyzed by homogentiate geranylgeranyl transferase (HGGT). Previously, we generated a tocotrienol-deficient mutant with shrunken barley grains.
View Article and Find Full Text PDFAdvanced oxidation process (AOP) based on peroxymonosulfate (PMS) has aroused extensive discussion in the degradation of organic pollutants due to the strong oxidative ability of SO. Great attention has been paid to developing transition metal catalysts for PMS activation. Still, few studies focused on the co-catalysis effect of non-redox metals.
View Article and Find Full Text PDFThe combination of polysaccharides can obtain stable, degradable, and environmentally friendly hydrogels, which have broad application prospects in adsorbents assembly. With Ca and Mg as crosslinkers, a new pectin/Konjac glucomannan/Ca-Mg composite hydrogel was prepared for phosphate adsorption by the alkali-thermal co-reaction method. Since Mg(OH) can create a suitable pH condition for phosphate adsorption by Ca, Ca and Mg synergistically promoted phosphate adsorption and remained stable in the pH range of 4 to 10.
View Article and Find Full Text PDFThe Er(OTf)-catalyzed cascade cyclization reaction of -quinone methides (-QMs) with various 1,3-dicarbonyl compounds has been developed, which efficiently constructed a series of versatile 4-aryl-3,4-dihydrocoumarins and 4-aryl-4-chromenes. Herein, we not only propose a novel cyclization strategy of -QMs, but also provide an easy access to structurally diverse coumarins and chromenes.
View Article and Find Full Text PDFIn recent years, researchers have devoted themselves to developing composites containing cobalt as highly active heterogeneous catalysts of persulfate. Most of them reported that the catalytic degradation processes of organic pollutants were accompanied by the leaching of cobalt ions, but only a few studies considered the contribution of the dissolved cobalt ion to the degradation of organic compounds. A research paper in Journal of Hazardous Materials reported a study on synthesis, application and catalytic mechanisms of cobalt doped hydroxyapatite (Co-HAP) for Rhodamine B (RhB) degradation.
View Article and Find Full Text PDFCirc Arrhythm Electrophysiol
April 2023
Background: Multiple screw-in attempts under fluoroscopy are often needed to place the pacing lead tip near or at the left bundle branch (LBB). This study was conducted to evaluate the feasibility of implanting an LBB pacing lead in the proximal LBB (PLBB) guided by intracardiac echocardiography (ICE).
Methods: The distribution of the LBB was initially determined by ICE anatomic imaging and 3-dimensional electrical mapping of His and LBB potentials in 20 patients in the first parts of the study.
Isoprene is the most abundant non-methane hydrocarbon (NMHC) emitted by vegetation, and the precursor that makes the greatest contribution to secondary organic aerosols (SOA) in the troposphere. Atmospheric oxidation of isoprene produces a series of reactive intermediates, isoprene epoxydiols (IEPOX). The reactive uptake of IEPOX is the significant formation pathway of atmospheric SOA.
View Article and Find Full Text PDFLivestock manure amendment, a common fertilization method for agricultural practice, can exacerbate antibiotic resistance gene (ARG) pollution, thus threatening food safety and human health. On the other hand, manure can also be produced as biochar to improve soil quality, which may reduce ARGs inside manure. However, it is unclear how and why shifting manure to biochar for soil amendment reduces ARG pollution.
View Article and Find Full Text PDFMagnetic nanoparticles (NPs) are powerful agents to induce hyperthermia in tumours upon the application of an alternating magnetic field or an infrared laser. Dopants have been investigated to alter different properties of materials. Herein, the effect of zinc doping into iron oxide NPs on their magnetic properties and structural characteristics has been investigated in-depth.
View Article and Find Full Text PDFHuman immunodeficiency virus type 1 (HIV-1) can integrate viral DNA into host cell chromosomes to establish a long-term stable latent reservoir, which is a major obstacle to cure HIV-1 infection. The characteristics of the HIV-1 latent reservoir have not been fully understood. Here, we identified 126 upregulated plasma membrane proteins in HIV-1 latently infected cells by a label-free liquid chromatography-tandem mass spectrometry analysis.
View Article and Find Full Text PDFJ Colloid Interface Sci
November 2022
The evolutions of water/ice interface with distinct ice orientations are one of the central problems in sea ice growth. Some misunderstandings prevailed in previous hypothesis on morphological evolution of sea ice, which need the validation with carefully designed experiments. Up to now, there is no in-situ comparison of unidirectional freezing behavior between distinct ice orientations, which makes the previous hypothesis on sea ice growth skeptical about its physical basis.
View Article and Find Full Text PDFThe retrovirus HIV-1 integrates into the host genome and establishes a latent viral reservoir that escapes immune surveillance. Molecular mechanisms of HIV-1 latency have been studied extensively to achieve a cure for the acquired immunodeficiency syndrome (AIDS). Latency-reversing agents (LRAs) have been developed to reactivate and eliminate the latent reservoir by the immune system.
View Article and Find Full Text PDFWhether grain boundaries (GBs) premelt is a longstanding question, because of the difficulty of direct experimental tests. Here, we focused an optical beam to locally heat single GBs within bulk hard-sphere colloidal crystals, observing the melting dynamics at single-particle resolution by video microscopy. The melting point is determined by analysing both the Lindemann parameter and the critical nucleus size for homogeneous nucleation.
View Article and Find Full Text PDFZhongguo Shi Yan Xue Ye Xue Za Zhi
February 2022
Objective: To analyze the clinical characteristics of bloodstream infection (BSI) in patients treated by hematopoietic stem cell transplantation (HSCT).
Methods: The clinical characteristics, distribution of pathogenic bacteria causing BSI and drug sensitivity of 910 patients treated by HSCT in our department from January 2013 to June 2020 were retrospectively analyzed.
Results: Among 910 HSCT patients, 111 patients were diagnosed as BSI within 100 days after transplantation, and 98 patients showed BSI during the period of agranulocytosis.
(), a B-class MADS-box gene, is involved in floral organ determination but has rarely been studied in , which is a very popular ornamental tree species in China. Here, the full-length cDNA of a homologous gene (named ) was cloned from a flower bud of using the RACE technique. The has a 645 bp open reading frame, encoding 214 amino acids.
View Article and Find Full Text PDFDuring the outbreak of COVID-19, the fogging of goggles was a fatal problem for doctors. At present, there are many ways to prevent fogging by adjusting surface wettability. However, the mechanical properties of most super-hydrophilic antifogging coatings are poor, easy to lose their antifogging properties when encountering fingers or cloth friction.
View Article and Find Full Text PDFFreezing of ice has been largely reported from many aspects, especially its complex pattern formation. Ice grown from liquid phase is usually characteristic of lamellar morphology that plays a significant role in various domains. However, tilted growth of ice via transition from coplanar to noncoplanar in directional solidification has been paid little attention in previous studies and there was a misleading explanation of the formation of tilted lamellar ice.
View Article and Find Full Text PDFJ Phys Condens Matter
July 2021
Sea ice growth with lamellar microstructure containing brine channels has been extensively investigated. However, the quantitative growth information of sea ice remains lack due to the uncontrolled crystalline orientation in previous investigations. For the first time, weobserved the unidirectional growth of lamellar sea ice with well-manipulated ice crystal orientation and visualized tip undercooling of lamellar sea ice.
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