Publications by authors named "Lilibeth Lanza"
Article Synopsis
- Researchers focused on the G glycoprotein of the respiratory syncytial virus (RSV) as a promising vaccine target due to its ability to generate strong neutralizing antibodies and reduce disease severity in animal studies.!* -
- Three constructs were created to optimize the display of a key part of the G glycoprotein (Gcc), with one construct showing great immunogenicity in mice and a human model, suggesting its potential effectiveness as a vaccine.!* -
- The combination of the Gcc-Foldon construct with another stabilized nanoparticle (pre-F-NP) led to a bivalent vaccine that showed no interference and strong immune responses in RSV-primed macaques, plus effective protection in mice
A stabilized form of the respiratory syncytial virus (RSV) fusion (F) protein has been explored as a vaccine to prevent viral infection because it presents several potent neutralizing epitopes. Here, we used a structure-based rational design to optimize antigen presentation and focus antibody (Ab) responses to key epitopes on the pre-fusion (pre-F) protein. This protein was fused to ferritin nanoparticles (pre-F-NP) and modified with glycans to mask nonneutralizing or poorly neutralizing epitopes to further focus the Ab response.
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