A case of markedly impaired wound repair with angiostatic pazopanib in a patient who had Mohs surgery for a basal cell carcinoma.

This case report highlights the adverse effects of pazopanib, a vascular endothelial growth factor receptor inhibitor, on wound healing after Mohs surgery. A 79-year-old male with metastatic renal cell carcinoma of the lung, on 600 mg daily pazopanib, underwent Mohs surgery for a nodular basal cell carcinoma on his right leg. Despite multiple wound care strategies, his wound deteriorated over 4 months.

MOC-31 Antibody Immunolabeling During Mohs Surgery.

Background: Ber-EP4 is an antibody that labels basal cell carcinoma (BCC) by targeting epithelial cell adhesion molecule (Ep-CAM). MOC-31, a monoclonal mouse antibody, also targets Ep-CAM and is currently used to differentiate several extracutaneous epithelial tumors. However, the utility of MOC-31 has not been fully described in cutaneous tumors and in Mohs micrographic surgery (MMS).

A novel specialized suture and inserting device for the resuspension of ptotic facial tissues: early results.

Background: In the past decade, the popularity of minimally invasive procedures for facial rejuvenation has increased.

Objective: To describe a new specialized suture, and its associated technique, used to elevate sagging tissues of the face and neck.

Methods: A detailed description of the technique and the results obtained in 20 patients in whom we have used this novel approach.

Wound bed score and its correlation with healing of chronic wounds.

Adequate wound bed preparation is essential for healing of leg ulcers, and consists of controlling exudate and edema, decreasing the bacterial burden, promoting healthy granulation tissue, and removing necrotic tissue. Currently, there is no classification system for wound bed preparation that has predictive value. Based on past work and the authors' experience, we have now developed and tested a new classification system that scores the following parameters: healing edges (wound edge effect), presence of eschar, greatest wound depth/granulation tissue, amount of exudate amount, edema, peri-wound dermatitis, peri-wound callus and or fibrosis, and a pink/red wound bed.

Safety and efficacy of a bilayered skin construct in full-thickness surgical wounds.

This was a prospective, randomized, controlled clinical trial assessing the safety and efficacy of a living bilayered skin construct (BSC; Organogenesis, Canton, MA) in treating full-thickness surgical excision wounds. We enrolled 31 patients needing excision of a non-melanoma skin cancer. The patients consisted of 18 females and 13 males, with an average age of 67 years (range: 44 to 84 years).

Contact sensitivity in patients with leg ulcerations: a North American study.

Objectives: (1) To determine the prevalence of allergen sensitivity in patients with past or present leg ulcers in 2 North American study centers vs European study findings and the North American Contact Dermatitis Group (NACDG) database and (2) to delineate a standard battery of allergens for patch testing in North American patients that is representative of the newer dressings and wound care products.

Design: Fifty-four patients, with or without dermatitis, were prospectively entered in the study. The patients were patch tested to the NACDG standard series and a comprehensive supplemental series of 52 allergens.

Clinical classification of bioengineered skin use and its correlation with healing of diabetic and venous ulcers.

Background: Chronic wounds are being treated with bioengineering skin constructs. Yet, there is no standard way of assessing these wounds. We developed a classification system to evaluate wounds after construct application.

Debridement performance index and its correlation with complete closure of diabetic foot ulcers.

In recent years there has been wider acceptance of aggressive surgical debridement as a means to accelerate closure of diabetic foot ulcers. In a clinical trial by Steed et al.1 involving the use of a topically applied growth factor, thorough surgical debridement of surrounding callus, necrotic ulcer bed, and undermined ulcers' edges was associated with greater incidence of healing and effectiveness of the therapeutic agent.