The burden of headache disorders among adults in Peru: national estimates and a health-care needs assessment from a population-based door-to-door survey.

Background: We have previously found that almost two thirds (64.6%) of adults in Peru have an active headache disorder. Here, using data from the same sample, we present attributed burden at individual and population levels.

The prevalence and demographic associations of headache in the adult population of Peru: a national cross-sectional population-based study.

Background: The Global Campaign against Headache is conducting a series of population-based studies to fill the large geographical gaps in knowledge of headache prevalence and attributable burden. One major region not until now included is South America. Here we present a study from Peru, a country of 32.

How to Advance Palliative Care Research in South America? Findings From a Delphi Study.

Context: Progress in palliative care (PC) necessarily involves scientific development. However, research conducted in South America (SA) needs to be improved.

Objectives: To develop a set of recommendations to advance PC research in SA.

Consensus of the Liaison-Psychiatry Committee of the Colombian Psychiatric Association on the diagnosis and treatment of delirium in the context of the COVID-19 pandemic.

The pandemic caused by the new coronavirus named SARS-CoV-2 poses unprecedented challenges in the health care. Among them is the increase in cases of delirium. The severe SARS-CoV-2 disease, COVID-19, has common vulnerabilities with delirium and produces alterations in organs such as the lungs or the brain, among others, which have the potential to trigger the mental disorder.

Cyclin-dependent kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle.

Hair follicles regenerate periodically by spontaneously undergoing cycles of growth, regression, and relative quiescence. During the hair cycle, follicle stem cells residing in a specialized niche remain quiescent, and they are stimulated to proliferate throughout the growth phase of the hair follicle. Although cell cycle regulators play a prominent role during the activation of hair follicle stem cells, the identity and the role of these regulators have not been confirmed.

CDK4 has the ability to regulate Aurora B and Cenpp expression in mouse keratinocytes.

Cyclin-dependent kinase 4 (CDK4) is a critical molecule that regulates key aspects of cell proliferation through phosphorylation of the retinoblastoma (Rb) family of proteins. In the last few years, it has been suggested that CDK4 plays alternative roles in cell proliferation and tumorigenesis. The main aim of the present study was to define a novel CDK4 function as a transcriptional regulator of genes involved in chromosome segregation, contributing to the G/M phase transition.

Educational Intervention on Human Papillomavirus in University Students.

Introduction: In recent years, there has been an increase in the number of cases of women and men suffering from a sexually transmitted disease.

Objective: The objective of this study was to implement an educational intervention on the human papillomavirus (HPV) to increase knowledge about the disease among university students.

Materials And Methods: In a preexperimental study with 385 students of both genders, the strategy was designed under the parameters of the PAHO and the Theory of Beliefs in Health.

Re-thinking the Etiological Framework of Neurodegeneration.

Neurodegenerative diseases are among the leading causes of disability and death worldwide. The disease-related socioeconomic burden is expected to increase with the steadily increasing life expectancy. In spite of decades of clinical and basic research, most strategies designed to manage degenerative brain diseases are palliative.

Acceptability and feasibility of using digital vending machines to deliver HIV self-tests to men who have sex with men.

Objective: Technology-based approaches to distribute HIV self-tests (HIVST) have the potential to increase access to HIV testing in key populations. We evaluate the acceptability and feasibility of using vending machines (VMs) in a community setting to distribute HIVST to men who have sex with men at high-risk of HIV.

Methods: First, a predevelopment survey of targeted potential users explored attitudes towards HIVST and the use of a VM to deliver HIVST.

Regional and inter-regional economic rules and the enforcement of the right to health: The case of Colombia.

The regional policy level is often seen as a (potential) source of progressive policy-making in health (and in social policy more widely), complementing or substituting national policy levels, which are perceived as underperforming. While it can certainly be argued that there are important opportunities to adopt regional approaches to tackle border-crossing health issues, this article draws the attention to the fact that the linkage between (inter-)regional and national policy levels is not uni-directional. While in some instances the regional level may indeed take the lead in the promotion of (the right to) health, in other instances it may well be the other way round.

The Role of Social and Personal Identities in Self-Esteem Among Ethnic Minority College Students.

This study examined the latent personal-social identity profiles that emerged from simultaneous consideration of ethnic, national (United States), and personal identities among ethnic minority college students ( = 3,009) as well as how personal and social identities are jointly associated with self-esteem. Results indicated that the structure of personal-social identity profiles significantly differed across ethnicity, but also indicated some commonalities. The study identified three profiles among Blacks, four among Asian Americans, and two among Latinos.

Identification of dengue fever cases in Houston, Texas, with evidence of autochthonous transmission between 2003 and 2005.

Houston, Texas, maintains an environment conducive to dengue virus (DENV) emergence; however, surveillance is passive and diagnostic testing is not readily available. To determine if DENV is present in the area, we tested 3768 clinical specimens (2138 cerebrospinal fluid [CSF] and 1630 serum) collected from patients with suspected mosquito-borne viral disease between 2003 and 2005. We identified 47 immunoglobulin M (IgM)-positive dengue cases, including two cases that were positive for viral RNA in serum for dengue serotype 2.

Perceived racial/ethnic discrimination and antisocial behaviors among Asian American college students: testing the moderating roles of ethnic and American identity.

The present study tested the moderating roles of ethnic identity and American identity on the association between perceived racial/ethnic discrimination and antisocial behaviors among Asian American college students. Using data from the Multi-Site University Study of Identity and Culture (MUSIC) collaborative, the sample included 1,362 East Asian and South Asian American college students. Perceived discrimination was significantly associated with antisocial behaviors for both East Asians and South Asians.

Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteins.

The serine protease autotransporters of Enterobacteriaceae (SPATEs) are secreted by pathogenic Gram-negative bacteria through the autotransporter pathway. We previously classified SPATE proteins into two classes: cytotoxic (class 1) and noncytotoxic (class 2). Here, we show that Pic, a class 2 SPATE protein produced by Shigella flexneri 2a, uropathogenic and enteroaggregative Escherichia coli strains, targets a broad range of human leukocyte adhesion proteins.

Acute reduction of serum 8-iso-PGF2-alpha and advanced oxidation protein products in vivo by a polyphenol-rich beverage; a pilot clinical study with phytochemical and in vitro antioxidant characterization.

Background: Measuring the effects of the acute intake of natural products on human biomarker concentrations, such as those related to oxidation and inflammation, can be an advantageous strategy for early clinical research on an ingredient or product.

Methods: 31 total healthy subjects were randomized in a double-blinded, placebo-controlled, acute pilot study with post-hoc subgroup analysis on 20 of the subjects. The study examined the effects of a single dose of a polyphenol-rich beverage (PRB), commercially marketed as "SoZo(®)", on serum anti-inflammatory and antioxidant markers.

An anthrax subunit vaccine candidate based on protective regions of Bacillus anthracis protective antigen and lethal factor.

Studies have confirmed the key role of Bacillus anthracis protective antigen (PA) in the US and UK human anthrax vaccines. However, given the tripartite nature of the toxin, other components, including lethal factor (LF), are also likely to contribute to protection. We examined the antibody and T cell responses to PA and LF in human volunteers immunized with the UK anthrax vaccine (AVP).

Identity consolidation and health risk behaviors in college students.

Objectives: To investigate the protective role of personal identity consolidation against health risk behaviors in college-attending emerging adults.

Methods: A multisite sample of 1546 college students completed measures of personal identity consolidation and recent risk behavior engagement.

Results: Multivariate Poisson regression indicated that personal identity consolidation was negatively related to binge drinking, illicit drug use, sexual risk behaviors, and risky driving.

Athletic involvement and its relevance to hazardous alcohol use and drinking game participation in female college athletes: a preliminary investigation.

Objective And Participants: The authors designed this cross-sectional study to examine sports team differences in hazardous alcohol use and drinking game participation, as well as the social correlates of these behaviors among female college athletes (N = 176; M age = 19.9 years, SD = 1.24, range = 18-22).

Clostridium difficile infection in patients with ileal pouch-anal anastomosis.

Background & Aims: There has been an increase in the incidence and severity of Clostridium difficile-associated diarrhea in the U.S. The importance of C difficile infection in patients with ileal pouch-anal anastomosis (IPAA) is unknown.

Drinking games in female college students: more than just a game?

The present study examined the characteristics of drinking games (DG). Study participants were 164 female college students (Mean age=20; 18-23 years) who completed self-report measures of DG participation and alcohol-related behaviors. Results showed variations in popularity, type of alcohol consumed, and intoxication levels across DG.