Systemic lupus erythematosus (SLE) is an autoimmune disease that affects multiple organs, and its coexistence with Giant Cell Arteritis (GCA) is extremely rare. We present, to our knowledge, the first reported case of a 56-year-old woman with SLE and extracranial GCA who presented with chest pain as the cardinal symptom. The diagnosis was subsequently confirmed by imaging studies, ruling out Takayasu arteritis and SLE-related vasculitis.
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