Publications by authors named "Liliana Giuliano"
Article Synopsis
- TLQP-21 is a neuropeptide involved in regulating physiological functions, specifically energy balance, and may influence obesity, prompting research into its mechanisms in different tissues.
- The study used [F]JMV5763, a radiolabeled analog of TLQP-21, to track its distribution in brain and peripheral tissues via positron emission tomography (PET) after systemic administration in mice.
- Results showed high uptake of [F]JMV5763 in the stomach, intestine, kidney, liver, and adrenal gland, but low uptake in the brain, indicating difficulty crossing the blood-brain barrier, and highlighted the effectiveness of using F-labeling for studying TLQP-21's distribution.
The use of polymers naturally occurring in the extracellular matrix (ECM) is a promising strategy in regenerative medicine. If compared to natural ECM proteins, proteins obtained by recombinant DNA technology have intrinsic advantages including reproducible macromolecular composition, sequence and molecular mass, and overcoming the potential pathogens transmission related to polymers of animal origin. Among ECM-mimicking materials, the family of recombinant elastin-like polymers is proposed for drug delivery applications and for the repair of damaged elastic tissues.
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