Toxic effects of environmental-relevant exposure to polyethylene terephthalate (PET) micro and nanoparticles in zebrafish early development.

Polyethylene terephthalate (PET) is a commonly used thermoplastic in industry due to its excellent malleability and thermal stability, making it extensively employed in packaging manufacturing. Inadequate disposal of PET packaging in the environment and natural physical-chemical processes leads to the formation of smaller particles known as PET micro and nanoplastics (MNPs). The reduced dimensions enhance particle bioavailability and, subsequently, their reactivity.

Acid mine drainage (AMD) treatment by neutralization: Evaluation of physical-chemical performance and ecotoxicological effects on zebrafish (Danio rerio) development.

Acid mine drainage (AMD) represents a major problem in the mining industry worldwide due to the risk of water and soil pollution. Its active treatment involves the addition of alkaline reagents such as NaOH or Ca(OH) to increase the pH and precipitate the dissolved metals, although substantial amounts of dissolved ions might persists. Under a remediation approach, the aim of this work was to assess the chemical and physical characteristics of treated effluent and to evaluate its ecotoxicological effects on zebrafish (Danio rerio) embryonic and larval stages, through developmental, functional, morphological, and behavioral end-points.

Standardization of capillary electrophoresis for diagnosis of fragile X syndrome in the Brazilian public health system.

Fragile X syndrome (FXS) is the most common cause of inherited intellectual disability. The most common etiology of the syndrome is expansion and methylation of a CGG trinucleotide at chromosome region Xq27.3 involving FMR1 (fragile X mental retardation 1 gene).