Publications by authors named "Lilian Pelattini"
A mismatch between striatal cholinergic pauses and dopaminergic reward prediction errors.
Proc Natl Acad Sci U S A
October 2024
Article Synopsis
- Striatal acetylcholine and dopamine play critical roles in regulating movement, motivation, and how we learn about rewards.
- Researchers studied cholinergic interneuron (CIN) firing during decision-making in freely moving rats and found that CIN activity and dopamine release varied significantly across different striatal regions.
- In the dorsal-lateral striatum, CIN firing patterns were not linked to reward prediction errors (RPE), while in the ventral striatum, both CINs and dopamine increased in response to rewards, highlighting complex interactions within the striatum.
Animals make predictions to guide their behavior and update those predictions through experience. Transient increases in dopamine (DA) are thought to be critical signals for updating predictions. However, it is unclear how this mechanism handles a wide range of behavioral timescales-from seconds or less (for example, if singing a song) to potentially hours or more (for example, if hunting for food).
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